Barole 10 mega We Care medicine for treatment of ulcerative ulcerative gastroesophageal - esophagus, gastric ulcer - duodenum (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Rabeprazole
Ingredient Peptic ulcer, stomach reflux, heartburn

Ingredient

Thành phần cho 1 viên

Composition information	Content
Rabeprazole	10mg

Uses

indications

Barole 10 mega drug is indicated in the following cases:

Treatment of ulcerative ulcer due to gastroesophageal reflux syndrome (GERD): Rabeprazol is indicated for short -term treatment (from 4 - 8 weeks) to heal and reduce symptoms of ulcerative gastroesophageal and esophagus. Burns in patients with gastroesophageal and esophagus ulcer. Most patients achieve treatment results within 4 weeks. Benzimidazole inhibits proton pump), has no antihistamine effect at H2 receptor or cholinergic resistance, but prevents gastric acid secretion due to inhibition of H+, K+ATPase in stomach walls. These enzymes are considered to be proton pumps in the wall cells, so Rabeprazol is considered as an inhibitor of proton pump. Rabeprazole prevents the final stage of gastric acid secretion. In stomach wall cells, Rabeprazol is protonized and converted into active sulfenamid and then attached to the cysteine of the proton pump that makes this enzyme inactivated.

Acid secretion effect:

After taking the dose of 20mg Rabeprazol, the effect of inhibiting gastric acid secretion will appear within 1 hour, maximum effect in 2-4 hours. The ratio of basic acid secretion and stimulating food at 23 hours after taking Rabeprazol's first dose is 69% and 82% in order and inhibitor time can last up to 48 hours. The effect of inhibiting acid secretion increases slightly at a daily dose once and stabilizes after 3 days of medicine. Acid secretion returns to normal after 2-3 days of stopping the drug.

Dynamic pharmacokinetics

When taking orally 20 mg Rabeprazol, the peak of plasma peaks achieved after 2-5 hours. There is no significant accumulation when taking 10mg - 40mg dose for 24 hours, Rabeprazol's pharmacokinetics does not change by high doses.

Selling plasma waste time is 1-2 hours. Rabeprazol is detected in plasma after 1 hour oral orally at a dose of 20 mg. The absolute bioavailability of Rabeprazol hard capsules is about 52%. 93% Rabeprazole binds to plasma proteins.

Rabeprazol is strongly metabolized, the main metabolic form detected in plasma is thioete and sulphon. There is no excretion inhibition in these forms of metabolic. In vitro tests show that Rabeprazol is metabolized mainly through the liver, due to Cytochrom P450 3A (Sulphon form) VA 2C19 (Desmethyl Rabeprazol), 90% of urine excreted drugs, mainly in the form of thioete carboxylic acid, vnicuronid bonding format and mercapturic acid metabolism.

rabeprazol gives anti -secreting effect within 1 hour after taking the dose of 20mg. The average inhibitory effect of rabeprazol on the acidity of the stomach within 248 is equal to 88% of the maximum after using the single dose. Compared to the placebo, Rabeprazol 20mg inhibits acidic excretion due to irritation

Because of normal meals and 86% and 95% pepton meals, and increasing the percentage of the period of 24 hours and the stomach has a pH> 3 from 10% to 65%. The impact of this radio force compared to the short selling time of the drug (1 - 2 hours) shows the prolonged inhibition effect on H+, K+ATPASE.

Special cases

Age: Reports in clinical studies on healthy older people show that the value of AUC has nearly doubled and CMAX increases 60% when compared to the young group. There is no evidence of the accumulation of drugs when used 1 time/day. Rabeprazole among healthy volunteers and patients with hemolysis. There is no information on patients with severe liver failure.

Before taking Barole 10 mega We Care medicine for treatment of ulcerative ulcerative gastroesophageal - esophagus, gastric ulcer - duodenum (10 blisters x 10 tablets)

How to use

oral tablets. It is recommended to take hard capsules, not chewed, crushed or cut pills before drinking.

Dosage

Barole 10 mega should be used before meals.

Treatment of ulcers caused by gastroesophageal reflux disease

The recommended dose for adults is 20 mg Rabeprazol/day for 4 - 8 weeks.

Treatment of ulcerative ulcers caused by gastroesophageal reflux disease

recommended dose for adults is 20 mg Rabeprazol/day.

Treatment of stomach ulcer, duodenum

The recommended dose for adults is 20 mg Rabeprazol/day after breakfast for 4 weeks. Most patients achieve results after 4 weeks.

Treatment of disease secretion, including Zollinger-Elison syndrome

Different doses in each patient:

The recommended starting dose for adults is 60 mg/time/day. Dosage should be adjusted depending on the needs of each patient and use continuously for a period depending on the treatment requirements. Dosage can be up to 60 mg 2 times/day and 100 mg/time/day. In patients with mild to moderate renal failure, the impact of rabeprazol increases and reduces excretion. Due to the lack of clinical information about rabeprazol in patients with severe renal impairment, caution should be cautious on these subjects.

Recommended the combination of the following drugs within 7 days with the dose of Rabeprazol 20 mg/time, 2 times/day + Clarithromycin 500 mg/time, 2 times/day and amoxicillin 1 g/time, 2 times/day. The drug is taken in the morning and evening.

What to do when overdose? Patients with Zollinger-Elison syndrome have been treated with a dose of up to 120 mg/time/day. Without specific antagonists, Rabeprazol is strongly connected to plasma proteins so it cannot be fertilized. In case of overdose, supportive treatment and symptoms.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

Common (1/100

Infections, insomnia, headache, dizziness, cough, sore throat, rhinitis, diarrhea, nausea, abdominal pain, constipation, this slightly, unexplained pain, back pain, weakness, influenza symptoms.

Less (1/1000

restlessness, drowsiness, indigestion, dry mouth, belching, itching, rash, muscle pain, cramps, joint pain, urinary tract infections, chest pain, chills, fever, liver enzyme.

Rare (1/10000

Neutral polygonal leukemia, leukopenia, thrombocytopenia, leukemia, hypertension, anorexia, depression, visual disorders, gastritis, tooth inflammation, taste disorders, hepatitis, jaundice, liver, itching, sweating, water -sweat reaction, interstitial kidney, weight gain.

Very rare (ADR

Diverse roses, poisoned epidermal necrosis, Stevens-Johnson syndrome.

ADR does not know the ratio

Hypothesis, peripheral edema, large breasts in men.

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Barole 10 mega drug is contraindicated in the following cases:

Contraindicated in patients with hypersensitivity to rabeprazol, benzimidazol derivatives or any ingredients of the drug.

Be cautious when used

The response to Rabeprazol does not prevent the appearance of tumors in the stomach. Therefore, it is necessary to rule out the possibility of cancer before using the drug.

There may be severe liver failure, blistering on the skin, red skin. Stop using the drug when there is a recurrence of skin lesions.

Not recommended for children.

Treatment with proton pump inhibitors, including rabeprazol, can increase the risk of gastrointestinal tract infections with salmonella, campylobacter and clostridium difficile. Using special proton bomb inhibitors at high doses and for a long time (over 1 year), which can increase the risk of hip, wrist and spine fractures, mainly occurs in the elderly or those with other risk factors. Studies record that proton pump inhibitors may increase the risk of fractures from 10 to 40%. Some of these cases may be due to other risk factors. Patients with the risk of osteoporosis should be treated according to the current regimen and they should use vitamin D in combination with calcium. Serious hematoma has been recorded in patients treated with proton pump inhibitors such as Rabeprazol for at least 3 months and most of them are about 1 year. The serious manifestations of bloody lower blood like fatigue, muscle spasms, delirium, convulsions, dizziness and ventricular arrhythmia may occur but they can progress silently and may be overlooked. In most patients, blood mangesi reduction is improved after adding mangesi and stopping the use of proton pump inhibitors.

The effect of the drug on driving and operating machinery

There has been no research on the effect of the drug on the ability to drive and operate machinery. However, based on unwanted effects, the drug can cause headaches or dizziness, recommend not to drive or operate machines when using Rabeprazol.

Using drugs for women during pregnancy and lactating

Pregnant and lactating women: Contraindications in pregnant and lactating women. Age.

Drug interaction

rabeprazol is metabolized through the enzyme system to metabolize Cytochrom P450 (CYP450) but there is no significant clinical interaction with other drugs transformed through the CYP450 system such as Warfarin, Theophylin, Diazepam and Phenytoin.

rabeprazol gives prolonged excretion of gastric acid secretion, so it can occur in interaction with drugs where the level of absorption depends on the stomach pH such as ketoconazole (down 33%). Therefore, patients need to be carefully monitored when using rabeprazol with these drugs. The common use of rabeprazol and antacids does not change rabeprazol levels in plasma.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children, read the user manual carefully before use.

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