Basethyrox 100mg Hataphar medicine for hyperthyroidism (100 tablets)

Dosage form 100 capsules
Specifications Propylthiouracil
Ingredient Ha Tay Pharmaceutical Joint Stock Company

Ingredient

Composition information	Content
Propylthiouracil	100mg

Uses

indications

Basethyrox 100mg drugs indicate treatment for hyperthyroidism to prepare for surgery, use associated with radioactive iodine for quick recovery while waiting for irradiation, handling of armor poisoning, basedow disease.

Pharmacokic

Propylthiouracil (PTU) is the substance of the thorên, an anti -thyroid drug.

Synthetic inhibitors of thyroid hormones by preventing iodine attaching to the tyrosyl section of thyroglobulin.

The drug also inhibits the pairing of these iodotyrosyl roots to create iodothyronin.

In addition to the synthesis of hormone synthesis, the drug also inhibits the iodine reduction process of T4 (thyroxin) to T3 (tri iodeothyronin) in the periphery.

The drug does not inhibit the effects of the hormone available in the thyroid or circulatory or exile hormone into the body.

Patients with high iodine concentrations in the thyroid gland (due to medication or use of iodine in diagnosis) can be slowly responded to anti -thyroid drugs.

Propylthiouracil (PTU) is used to temporarily treat the state of hypertension, as an auxiliary drug to prepare for surgery or radioactive iodine, and when there is a contraindication to remove the thyroid gland, or to treat symptoms of hyper armor due to basedow disease and maintain hyperpigmentation state for a few years (usually 1-2 years) until the disease is spontaneous.

The drug does not work the cause of armor energy and is often not used for a long time to cure armor energy.

Non -rhetorical diseases in all patients treated with propylthiouracil or other anti -thyroid drugs and most of them finally need removal (surgical, radioactive iodine).

The minimum time using propylthiouracil is long before evaluating whether the disease will be spontaneously regression, it is unknown.

Propylthiouracil can be used for children to increase armor energy to try to postpone removal therapy, if the disease does not retreat with Propylthiouracil therapy, sometimes the drug is continued to use for a few years to delay the removal until the child is older.

Propylthiouracil is used to transfer people to increase the ability to return to normal metabolism before surgery and to control the toxicity of the armor can accompany the thyroid removal.

Propylthiouracil is also used as an auxiliary drug for radioactive iodine therapy in patients who need to control the symptoms of increased armor function and while using radioactive iodine until it works.

In the treatment of armor poisoning, iodid (for example, potassium iodide solution, strong iodine solution) is used to inhibit the hormone thyroid lifetime but then it can be used as a substrate to synthesize thyroid hormones; Therefore, propylthiouracil treatments often begin to treat before taking iodid therapy.

Beta - adrenergic blockers (e.g. propranolol) is also often given simultaneously to process the signs and peripheral symptoms of increased armor energy, especially cardiovascular effects (for example, tachycardia).

Dynamic pharmacokinetics

absorption

Propylthiouracil is absorbed quickly and easily through the gastrointestinal tract (about 75%) after taken.

Peak concentration in plasma is about 6 - 9 micrograms/ml, which takes place within 1 - 1.5 hours after a single dose 200 - 400mg.

Plasma concentration seems not corresponding to the treatment effect.

distribution

Although the full distribution properties of propylthiouracil have not been determined in tissue and fluid, it seems that the drug is mainly concentrated in the thyroid gland.

Elimination

Half lifetime elimination of propylthiouracil is generally about 1-2 hours.

Although the exact metabolism has not been fully metabolized, propylthiouracil, quickly transformed into glucuronid and other secondary metabolites. Therefore, it is necessary to take medication regularly to maintain an anti -thyroid effect.

Medicines and metabolites excreted in the urine, with about 35% the dose is excreted within 24 hours.

Before taking Basethyrox 100mg Hataphar medicine for hyperthyroidism (100 tablets)

How to use

Basethyrox 100mg tablets for oral tablets.

Dosage

Daily dose of drugs is usually divided into 3 small doses orally about 8 hours.

In some cases, when needed daily is greater than 300 mg, can be taken at a closer distance (for example, every 4 or 6 hours).

Adults

The usual dose of thyroid hyperplation treatment in adults:

Initial doses used for adults are 300 - 450 mg, divided into small dose orally 8 hours apart; Sometimes the patient has a very large hyperthyroidism and/or goiter, which may need an initial dose of 600 - 1200 mg per day. Up to two -thirds of the initial dose.

Propylthiouracil dose is 200 mg, every 4-6 hours of drinking on the first day, when completely controlled symptoms, gradually decreases to the common maintenance dose.

Common dose in the treatment of hyperthyroidism in children:

Initially used dose is 5-7 mg/kg/day, divided into small doses, taken 8 hours apart, or 50 - 150 mg daily in children 6 - 10 years old, and 150 - 300 mg or 150 mg/batch per day for children 10 years old or larger.

1/3 to 2/3 of the initial dose, divided into small dose orally 8 - 12 hours apart.

Elderly people: Should take lower doses, the first dose 150 - 300 mg/day.

Dosage for patients with renal failure:

Creatinine clearance: 10 - 50 ml/min: dose equal to 75% common dose. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

generally overdose of propylthiouracil can cause many common ADRs such as nausea, vomiting, epigastric pain, headache, fever, joint pain, itching, covering the whole blood cell. Treatment:

Treatment of propylthiouracil overdose is usually symptomatic and supportive treatment. Full blood if the marrow failure develops. Analgesic, sedative and intravenous drugs can also be used to treat propylthiouracil overdose.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Basethyrox 100mg, you may experience unwanted effects (ADR).

ADR ratio due to propylthiouracil is relatively low; 1 - 5% of patients with leukemia.

The loss of grain leukemia is the most rare and serious ADR usually occurs within the first 3 months of treatment, and rarely occurs after 4 months of treatment.

ADR about rare liver, often recovered after stopping the drug, but hepatitis is deadly with brain disease and/or significant liver necrosis has occurred in a few patients.

Prolonged treatment with propylthiouracil can cause hypothyroidism.

Common, ADR> 1/100

Hematology: leukopenia. If the leukocytes below 4000, neutral white blood cells below 45%, must stop the drug.

Hematology: Loss of granulocytes. Kinh.

liver: jaundice, hepatitis.

Hematology: Absolute blood cells, thrombocytopenia, non -regenerated anemia, prothrombin - blood and bleeding.

Liver: Serious liver reaction.

Respiratory: interstitial pneumonia.

If granulocytosis, non -regenerated anemia (reduces all bloody hematoplei), hepatitis, fever, or peeling dermatitis, must stop propylthiouracil and start applying appropriate support and treatment.

Using the factor of stimulating recombinant agreement population can accelerate recovery from grain leukemia.

Must stop propylthiouracil immediately if there is an important clinical evidence of abnormal liver function (for example, serum transaminase levels exceed 3 times the upper limit of normal levels).

Hemorrhage, urticaria, and yard are often cured without having to stop the drug, but sometimes it is necessary to take antihistamine or other drugs, because diagonal sensitivity is not common. Must monitor thyroid function regularly in patients who are using propylthiouracil.

When the clinical evidence is seen increasing the thyroid energy, and the level of thyrotropine (hormone stimulates thyroid, tsh) in serum needs to be used in the maintenance dose of Propylthiouracil.

Prolonged treatment with propylthiouracil can cause thyroid reduction.

Needs to reduce the dose when there are the first signs of thyroid reduction; If these signs progress heavily, thyroid hormones may be used for early recovery. Can give a full dose of levothyroxin.

Note: "Notify the doctor unwanted effects when using the drug."

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Basethyrox 100mg drug contraindicated in the following cases:

Pre -severe blood diseases (for example, granulocytes, anemia ...).

hepatitis.

Caution when using

closely monitor patients who are using propylthiouracil about grain leukemia and instructing patients to see a doctor immediately if there are signs or symptoms that suggest infections, such as sore throat, skin rash, fever, chip, headache, or unpleasant body.

It is especially important to carefully monitor these signs and symptoms in the first phase using propyl -tiouracil, if the grain leukemia occurs due to propylthiouracil, it is usually in the first 2-3 months of treatment.

may also occur in leukopenia, reducing the amount of platelets, and/or anemia not regenerated (reducing all bloody hematomas).

Counting leukocytes and leukemia for people with fever or sore throat, or other signs of the disease while taking the drug.

Because of the increased risk of granulocytes with age, some clinical houses recommend that the supply is cautious for patients over 40 years old.

Must use propylthiouracil very carefully in patients who are using other drugs known as the potential to cause granulocytes.

Because propylthiouracil may cause prothrombin - blood and bleeding, prothrombin must be monitored during treatment with drugs, especially before surgery.

For patients with symptoms that suggest liver dysfunction (for example, anorexia, itching, pain in the lower right flank), there may be fatal liver reactions (though rare) in patients using propyliouracil.

Used for pregnant or lactating women

pregnancy:

propylthiouracil through the placenta, can be toxic to the fetus (goiter and hypothyroidism for the fetus). If you have to use the drug, you need to adjust the dose carefully, enough but not too high. potential for pregnancy.

Breastfeeding period:

Propylthiouracil is distributed into milk.

Drug interaction

drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Propylthiouracil can cause prothrombin - blood and thus can increase the effects of anticoagulants.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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