Basmetin 6mg Medisun treats bronchial asthma, rheumatoid arthritis (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Deflazacort
Ingredient Me di sun

Ingredient

Composition informationContent
Deflazacort6mg

Uses

indicated

basmetin used in the following cases:

  • Hypersensitivity reaction, bronchial asthma.
  • Rheumatoid arthritis, chronic arthritis.
  • Systemic lupus, dermatitis, connective tissue (unlike systemic sclerosis), arterial inflammation around the artery, sarcoidosis.

  • Pemphigus disease, pemphigoid disease, pus dermatitis.
  • Nephrotic syndrome has minimal damage, acute interstitial nephritis.

    Acute rheumatism.

  • ulcerative colitis, Crohn's disease.
  • Ivanitis, optic neuritis.
  • Auto immunity hemolytic anemia, plateletal decline.

    Acute and lymphatic leukemia, malignant lymphoma, myeloid pain.

  • Immune inhibitors during transplantation.
  • Pharmacokinus

    Deflazacort is a glucocorticoid. The drug has the main effect of anti -inflammatory and immunosuppressive inhibition, used in the treatment of many different diseases and is equivalent to other anti -inflammatory steroid agents. Studies show that the activity of deflazacort on prednisolon is about 0.69 to 0.89.

    Deflazacort is a corticosteroid, active metabolites, 21-Desacetyl Deflazacort, operating through glucocorticoid receptors to cause anti-inflammatory and immunosuppressive effects.

    Pharmacokinetics

    absorption

    Deflazacort is used by oral.

    Distribution

    The average semi-cancellation time in the plasma of Deflazacort 21-OH is 1.1 to 1.9 hours.

    Metabolism

    Deflazacort 21-oh is metabolized throughout the body and is immediately transformed by plasma esterase enzymes into an active substance metabolic substance with Deflazacort activity 21-oh. This metabolites achieve a peak concentration in plasma from 1.5 to 2 hours and 40% of the metabolites associated with plasma proteins and has no affinity with transcortin.

    Elimination

    The drug is excreted mainly through the kidneys, 70% of the dose is excreted for 8 hours after drinking. The rest is eliminated through feces. Only 18% of the drug is excreted in urine in the form of Deflazacort 21-OH, the Deflazacort 6-Beta-OH metabolites account for 1/3 of the urine.

    Before taking Basmetin 6mg Medisun treats bronchial asthma, rheumatoid arthritis (2 blisters x 10 tablets)

    How to use

    oral medication, the lowest dose possible.

    Use in the morning, use the lowest dose but still achieve treatment effect.

    Dosage

    Deflazacort is a glucocorticoid derived from Prednisolon and 6mg Deflazacort has anti -inflammatory effects similar to 5mg prednisolon or prednison.

    Dosage is different from patients, depending on the response and severity of the disease. When Deflazacort is used for a long time in chronic diseases, the maintenance should be maintained as low as possible. May need to increase the dose in the progression of the disease.

    The dosage of the drug is corrected according to the diagnosis, the severity of the disease and the patient's response. Should use the lowest dose but still ensure the effect.

    Adults

    For acute diseases: The initial dose of Dellazacort can be up to 120 mg/day. The maintenance dose is about 3 to 18 mg/day.

    Rheumatoid arthritis: maintenance dose is usually used from 3 to 18 mg/day. Use the lowest dose but still effective treatment.

    Bronchial asthma: In acute bronchial asthma attacks, the starting of high doses of 48 to 72 mg/day depends on the severity and gradually decreases after the control. To treat chronic asthma, use the lowest doses to control symptoms.

    Other diseases: Depending on the clinical needs, use the lowest doses to achieve treatment effect

    People with liver failure

    In patients with liver failure, Deflazacort's blood concentration may increase. Need to adjust the dose in patients with liver failure to achieve treatment effect.

    Renal failure

    For patients with severe renal impairment, glucocorticoids are only used when necessary, when other drugs are no longer enough to work.

    Elderly

    In elderly patients, when no longer responded to conventional therapies, use treatment with glucocorticoid. The adverse effects of systemic glucocorticoids may be more serious in the elderly.

    Children

    Data on the use of deflazacort is limited and cautious when used for children.

    In children, the indications for glucocorticoids are similar to adults, but need to be used at the lowest dose but still effective treatment.

    Deflazacort dose is usually in the range of 0.25 to 1.5 mg/kg/day. The dose when treating some diseases is as follows:

    Chronic arthritis in minors: The maintenance dose is usually from 0.25 to 1.0 mg/kg/day.

    Nephrotic syndrome: The starting dose is usually 1.5mg/kg/day then reduces the dose according to clinical response.

    Bronchial asthma: The starting dose is between 0.25 to 1.0 mg/kg Deflazacort, reducing the dose by clinical response.

    Stop using glucocorticoid

    In patients using systemic corticosteroids (about 9mg/day or equivalent) for more than 3 weeks, the use of drugs should not be sudden. The decrease in the dose of the drug should be considered at the clinical response of the patient, whether the disease recurs after reducing the dose. The disease is not likely to recur, should reduce the dose slowly, so that the axis of the hypothalamus-Yen-yen-adrenal recovery gradually, not reducing the sudden corticosteroid dose.

    Need to reduce corticosteroid dose in the following patient groups

    Patients using prolonged corticosteroids, especially over 3 weeks.

    Patients using low doses for a few months long, when stopping treatment also should reduce the dose slowly.

    Use external preparations, especially slow release preparations that absorb drugs into blood significantly, causing inhibition of pituitary axis such as systemic roads, need to reduce the dose slowly.

    Patients taking the body corticosteroid dose greater than 48 mg/day for deflazacort (or equivalent).

    Patients taking the drug in the evening.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

    do when overdose? Testing on materials for LD is greater than 4000 mg/kg.

    In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    When using Basmetin, you may experience unwanted effects (ADR).

    Common, ADR> 1/100

  • Metabolism and nutrition: weight gain.
  • Uncommon, 1/1000

  • Endocrine system: Inhibit the hypothalamus-yen-yen-adrenal, Cushing syndrome, amenorrhea.
  • Metabolism and nutrition: Carbohydrate tolerance disorders in diabetics use drugs, loss of potassium, hypokalemia when used with beta, xanthin, sodium and water -causing water. infection: Increasing sensitivity and severity of infection, inhibiting the manifestation of clinical signs, opportunistic infections, recurrence of pulmonary tuberculosis.

    Osteoarthritis system: Osteoporosis, vertebra and long bones.

  • Nervous system: headache, dizziness.
  • Mental system: Mental disorders, depression, behavioral disorders.

  • Digestive system: stomach ulcers, hemorrhage, nausea.
  • Skin and subcutaneous tissue: Acne, hairy, stretch marks.

    The immune system: Hypersensitivity reaction.

    Rare 1/10,000

  • musculoskeletal system: loss of muscle.
  • Skin and subcutaneous tissue: bruising.

    Unknown frequency

  • Endocrine system: Inhibition of growth in infants, children, adolescents.
  • Metabolism and nutrition: Increasing appetite, balancing protein and calcium calculated. infection: Candida infection.
  • Musculoskeletal system: tendonitis when used in combination with quinolon, muscle pain, bone and vascular necrosis, negative nitrogen balance.
  • Reproduction system: Menstrual disorders.
  • Cardiovascular system: heart failure.

  • Nervous system: restlessness, increased intracranial pressure with thorns in children (old brain tumors), usually after stopping treatment, worse more epilepsy.
  • Mental system: stimulating, excitement, hallucinations, exacerbating schizophrenia, anxiety, sleep disorders, cognitive disorders. Eye: increased internal pressure, glaucoma, thorns, cataracts, worse eye diseases.

  • Digestive system: Perforation of stomach, acute pancreatitis, candidiasis infection.
  • Skin and subcutaneous tissue: Skin atrophy, capillary dilatation.
  • general: edema. blood and lymph: leukopenia, thrombosis.

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Contraindicated

    Basmetin medicine is contraindicated in the following cases:

  • Hypersensitivity to the ingredients of the drug.
  • Patients using activity vaccine.
  • Patients who are infected with systemic infections unless anti -bacterial therapy is used.

    Caution when using

    to be out of reach of children.

    Read the instructions carefully when using the drug. Refer to the instructions of the doctor.

    Patients with sugar intolerance should not be used.

    Use the only dose in the morning and the lowest dose and still achieve the treatment effect. Adjust the appropriate dose in each patient.

    Adrenal inhibition occurs during treatment and may last even after stopping using the drug. Reducing corticosteroid dose after prolonged treatment should gradually gradually, avoiding impaired adrenal function may cause death, reduce the dose by week or month by dose and treatment time. During prolonged treatment, any bacterial infection, injury or surgical procedure must increase the temporary corticosteroid dose. If stopping using corticosteroids after prolonged treatment, it may be reused. Patients need to notify the doctor about having used corticosteroids for appropriate treatment.

    Anti -inflammatory, immunosuppressive effect

    Anti -inflammatory, immunosuppressive effects of corticosteroids increase the likelihood of infection and worsen the existing infections. Signs of serious infections such as bacterial infections, tuberculosis may be concealed, only detected when the progression has been evolved.

    For patients with immunodeficiency with chickenpox can lead to death, so it is necessary to take special care. Patients (or patient care) do not have a history of chickenpox should avoid contact with chickenpox or herpes zoster virus if exposed, so they should go to the medical facility immediately. There is a diagnosis of chickenpox in patients who are taking corticosteroids for systemic sugar or those who have used corticosteroids within 3 months ago, the special care regime should not stop corticosteroids, may need to increase the dose. Preventive treatment may be required with normal intramuscular vaccine.

    Do not inject vital vaccines for people with poor immune response. Antibody reactions to vaccines may be reduced.

    Be cautious when using the drug, which can reduce vision, stomach pain even when used in low doses.

    Prolonged use can cause cataracts, glaucoma, optic nerve damage, increase the likelihood of secondary eye infections caused by fungi or super bacteria.

    If glucorticoid is indicated in potential tuberculosis patients or positive tuberculin reactions, it is necessary to closely monitor the recurrence of the disease. Using glucocorticoid can cause meningitis, this effect of the drug can be increased when used with quinolon.

    The starch in this drug contains only very low gluten content and less harmful if the patient has Celiac disease.

    A unit of dose> does not contain more than 20 mcg gluten.

    If allergic to wheat (avoiding Celic disease), patients should not use this medication.

    The drug contains lactose excipients, so patients with rare genetic disorders such as galactose tolerance, completely lactase deficiency or absorbent Glucose Galactose should not use this drug.

    The following patients using glucocorticoids need to be closely monitored

    heart disease or congestive heart failure (except in the case of acute heart inflammation), hypertension, arterial thrombosis.

    Glucocorticoid can cause salt and water retention.

    Gastritis or esophagitis, appendicitis, ulcerative colitis are likely to be perforated, abscess or pneumonia, gastric ulcer.

    Diabetes or family history of people with osteoporosis, muscle weakness, kidney failure.

    Mental disorders, behavior.

    muscle pain caused by corticosteroids before.

    cirrhosis, liver failure can increase the effects of glucocorticoid.

    Herpes simplex in the eyes.

    Patients and patients should be instructed on unwanted effects related to mental disorders when using systemic glucocorticoid. Symptoms may appear within a few days or weeks after the beginning of treatment, prone to high doses in the body. Most manifestations of mental disorders will be lost after a decrease in the dose or patient medication and patient care should meet medical staff when there are psychological disorders, depression, suicide thoughts. Consider when using systemic corticosteroids in patients with mental disorders including previous depression, or family history.

    Glucocorticoid causes menstrual disorders and leukemia, cautious when using Deflazacort.

    Children

    corticosteroids that cause developmental retardation are related to dosage in newborns, young children and adolescents, cannot be submitted to the use of drugs.

    Elderly

    Unwanted effects of systemic corticosteroids. There may be more serious consequences in old age, especially osteoporosis, hypertension, hypokalemia, diabetes, susceptible to infection and skin thinning. When using the drug, it is necessary to monitor closely.

    Because the complications of the use of glucocorticoid depends on the dose and treatment time, the lowest dose must be used effectively and consider the risk of benefits because whether or not to use it regularly.

    The ability to drive and operate machinery

    The efficiency of corticosteroids for driving or using machinery has not been systematically evaluated. Dizziness is an unwanted effect that can occur after Deflazacort treatment. If affected, patients should not drive or operate machinery.

    pregnancy

    corticosteroids through the placenta at different levels depending on the type of drug, however, Deflazacort does not pass the placenta.

    The use of corticosteroids on pregnant animals may cause abnormalities to the fetus that does not have enough evidence that corticosteroids lead to an increase in the incidence of congenital abnormalities, such as open mouth/lips in humans. However, when taking the drug for a long time or repeating many times during pregnancy, corticosteroids may increase the risk of uterine retardation. Only use corticosteroids for pregnant women when really necessary, consider benefits and risks.

    The period of breastfeeding. The mother uses Deflazacort dose of up to 50 mg/day using the whole body sugar that does not affect babies. When using higher doses can cause adrenal inhibition. Need to consider the benefits and risks when using the drug, only used when really necessary.

    Drug interaction

    Deflazacort is metabolized in the liver. Deflazacort should be increased if used with liver enzyme induction drugs, such as rifampicin, rifabutin, carbamazepin, phenobarbiton, phenytoin, primidon and aminoglutethimid. For enzyme inhibitors, such as ketoconazole, Deflazacort can be reduced. Used with CYP3A4 inhibitors, increasing the side effects of corticosteroids, which should consider benefits and risks before use.

    In patients using estrogen, corticosteroid dose can be reduced.

    Effects of hypoglycemic drugs (including insulin), hypertension and diuretics increased when used with corticosteroids and potassium lowering effects of acetazolamid, diuretics, thiazid diuretics, beta -drewing drugs, carbenoxolons increase.

    The effectiveness of COUMARIN anticoagulants increases when used with corticosteroids and must closely monitor RNI or prothrombin time to avoid spontaneous bleeding.

    In patients treated with systemic corticosteroids, using non -reducing muscle relaxants can lead to prolonged muscle relaxation and acute muscle pain. Risk factors include prolonged and high doses of corticosteroid treatment and prolonged muscle paralysis time.

    Glucocorticoid causes immunosuppressive inhibitors, closely monitoring patients with infection symptoms encountered. Also using glucocorticoids and oral contraceptives should be closely monitored because the glucocorticoid concentration in plasma may increase. This effect may be due to a change in metabolism or attached to plasma proteins.

    Antacids can reduce the bioavailability of the drug. Use glucocorticoid 2 hours before using antacids.

    Salicylate's clearance through the kidneys increases due to corticosteroids and the stop use of steroids can lead to salicylate poisoning.

    Simultaneously used with CYP3A inhibitors, including products containing COBICISTAT, is expected to increase the risk of body side effects. The combination should be avoided unless the benefits beyond the risk of increasing the whole body side effects of corticosteroids due to the combination of drugs, in this case the patient should be monitored the side effects of the system of corticosteroids.

    Storage

    Storage in closed packaging, avoid moisture, avoid light, temperature below 30 ° C.

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