Batteen 200 dose 10ml nasal sprayer for treatment of allergic rhinitis (200 doses)

Dosage form Bottle x 10ml
Specifications Budesonide
Ingredient Nose polyps, allergic rhinitis

Ingredient

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Composition information	Content
Budesonide	100mcg

Uses

indications

Buyeren 200 Dose 10 ml drugs are indicated in the following cases:

allergic rhinitis all year round and each seasonal inflammation.

Treatment of nasal polyps.

Pharmacokic

Budesonide is a glucocorticosteroid with high -spot anti -inflammatory effect. The exact mechanism of impact of glucocorticosteroids in asthma treatment has not been fully understood. Anti -inflammatory impacts such as inhibiting the release of intermediate substances that cause inflammation and inhibitors of cytokin's immune response are important.

The activity of Budesonide is measured by its affinity for glucocorticosteroid receptors about 15 times higher than the activity of Prednisolone. When using backup before stimulating the nasal line, Budesonide proves to protect against the penetration of eosinophilia and cause hypersensitivity.

In the treatment dose, Buderen does not cause any clinical important changes at the basic level of cortisol in plasma as well as responding to ACTH's stimulation. However, the decrease in the amount of cortisol in plasma and urine related to the dose has been recorded in healthy volunteers after a short time of using Boderen.

Dynamic pharmacokinetics

budesonide has an integral distribution of about 3 l/kg. Combined with plasma protein is 85 - 90%. Budesonide metabolizes the first phase through strong liver (about 90%) into low -active metabolites. The main metabolites 6-B-hydroxybudesonide and 16-hydroxyprednisolone have glucocorticosteroid activity lower than 1% of this activity of budesonide.

Budesonide is not inactivated at the nose. Budesonide is eliminated by metabolism that is catalyzed mainly by CYP3A4 yeast. The metabolites are excreted through the kidneys in a constant form and a combination form. Budesonide is not found in the urine. Budesonide has a high body clearance (0.9 - 1.4 liters/minute), and the semi -cancellation time in plasma after an average intravenous injection is about 2-3 hours.

Before taking Batteen 200 dose 10ml nasal sprayer for treatment of allergic rhinitis (200 doses)

How to use

Before using Buderen spray for the first time, shake the drug and pump several times (5-10 times) into the air, to achieve a homogeneous spraying mixture. If not used every day, the pipe must be pumped again. This time, just pumping once into the air is enough.

Clean nose.

Shake the bottle. Open the protective lid.

Hold the medicine tube straight up.

Put the top of the pipe into the nostril and pump according to the prescribed dose. Similarly, pumping the drug on each other.

Cover the protective lid. Do not use Boderen more than the specified dose.

Dosage

Adults and children> 6 years old

Rhinitis: The recommended starting dose is 200 micrograms/day (1 spray in each nose). Clinical efficiency achieved after 1-2 weeks. The maintenance dose should be reduced to the lowest dose and still control symptoms. After achieving the desired clinical effect, the maintenance dose should be gradually reduced until the lowest dose needed to control symptoms.

Children

Should only use Boderen under the guidance of adults to ensure the right and the right dose of prescribed prescription.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? When using excessive doses for a long time, the effect of glucocorticosteroids like adrenal energy and adrenal medulla are likely to occur.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Buderen 200 Dose 10 ml, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Respiratory tract: on -site irritation, light nasal secretion, nosebleeds.

Rare, ADR

Systemic: Evaluation.

skin: urticaria, rash, dermatitis, itching.

Respiratory tract: Perforation of the nasal septum, mucosal ulcer.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Bodyeren 200 Dose 10 ml is contraindicated in cases where patients have a history of sensitivity to any component of the drug.

Be cautious when used

When long -term use at high doses, the systemic effect of glucocorticosteroids such as adrenal energy, adrenal medulla and/or growth retardation in children may occur. The long -term influence of nasal steroids in children. Cortisone -containing drug treatment can lead to developmental retardation.

Should regularly monitor the development of children and adolescents regularly when long -term treatment with corticosteroids, regardless of the route. If there is a suspected retardation, medication must be reviewed. The benefits of treatment for glucocorticosteroids must be placed in a correlation with the risk of development inhibitors.

Be cautious when treating patients from glucocorticosteroid-acting to the body to use Boderen when suspected of a shaft disorder of the hill-yen-yen-adrenal. In these patients, the system of systemic steroids should be carefully reduced and consider the test of the lower hill-yen-yen-adrenal function. Patients may also need to use more systemic steroids in stress stages such as surgery, injury ...

Severe liver function will affect the pharmacokinetics of oral budesonide, reducing the rate of excretion and increasing body biodiversity. Should pay attention to the body effects that may occur. It is necessary to specially monitor tuberculosis patients.

Should avoid exposure to eyes with the eyes. If Buderen is in contact with the eyes, should be washed immediately with water.

Should avoid simultaneously with ketoconazole or other powerful CYP3A4 inhibitors. If the combination must be used, the budesonide distance and these drugs as far as possible.

The ability to drive and operate machinery

Baderen does not affect the ability to drive and operate the machine.

Pregnancy

In animal studies, the use of Budesonide, as well as other glucocorticosteroids, can cause abnormalities for fetal development. Although this impact study in humans has not been identified, Buderen should not be used for pregnant women unless they are really needed.

breastfeeding period

budesonide excreted through breast milk. Buderen should not be used for breastfeeding women unless really necessary.

Interactive drug

Ketoconazole and other powerful CYP3A4 inhibitors: reducing Budesonid metabolism.

Storage

Store at temperatures below 30 ° C. To be out of reach of children.

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