Bazato 300mg Hasan treats neur pain symptoms (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Gabapentin
Ingredient Epilepsy, peripheral tk disease, anemia due to vitamin B12 deficiency

Ingredient

Composition information	Content
Gabapentin	300mg

Uses

indications

Bazato drugs are indicated in the following cases:

Treatment of neurological symptoms in adults

Includes: peripheral neuropathy, triple neuralgia, neurological pain in diabetic patients.

Pharmacology

gabapentin

gabapentin is an anti -epileptic drug, the mechanism is unclear. The chemical structure of Gabapentin is similar to neurotransmitter inhibitors, Gama-Aminobutyric Acid (GABA), but Gabapentin does not directly affect GABA receptors, does not change the structure, release, metabolize and recover GABA.

mecobalamin

mecobalamin is a endogenous b12 coenzym. Mecobalamin plays an important role in the methyl group transfer reaction as a coenzyme of Methionine Synthetase during the synthesis of methionine from Homocystein. Mecobalamine is effectively transported into the nerve cells, enhancing the synthesis of protein and nucleic acid. Mecobalamin promotes myelinization, synthesizing lecithin, the main component of the cordcing lipid. Mecobalamin helps restore damaged nerves and prevent abnormal nerve impulses. In addition, mecobalamin also promotes the maturity and division of the Red blood cells, synthesizing hem, thus treating anemia.

pharmacokinetics

gabapentin

absorption: Gabapentin absorbed through the gastrointestinal tract under saturated mechanism (when increased dose, bioavailability decreases). The drug reaches the peak concentration in plasma after 2 hours and reaches a stable concentration after 1-2 days. Gabapentin concentration in plasma is about 2 - 20 mg/liter. Birth is about 60% when taking a dose of 1.8 g for 24 hours. Food has little speed and absorption level.

Distribution: Gabapentin is distributed throughout the body, in breast milk, less linked to plasma proteins (

Metabolism: Gabapentin is almost no metabolism.

Elimination: Elimination mainly through the kidneys in the form of constant. Half life eliminates gabapentin about 5-7 hours in people with normal kidney function.

mecobalamin

absorption: Mecobalamin is linked to internal factors - a glycoprotein secreted from the stomach lining and is actively absorbed in the digestive tract.

Distribution: Mecobalamin is strongly attached to plasma proteins, transcobalamin and is transported to tissues. Mecobalamin is stored in the liver. Mecobalamin can diffuse through placenta and breast milk.

Metabolism: No report.

Elimination: Mecobalamin is excreted through bile, reabsorption according to the intestinal liver cycle and partly excreted into the urine for the first 8 hours.

Before taking Bazato 300mg Hasan treats neur pain symptoms (3 blisters x 10 tablets)

How to use

oral medication. Take the medicine at any time of the day. If the patient is nausea, should eat before taking the medication.

Dosage

First day: 1 tablet/time x 1 time/day.

Monday: 1 tablet/time x 2 times/day.

Tuesday: 1 tablet/time x 3 times/day.

then can increase to 2 capsules/time x 3 times/day.

The average effective dose of mecobalamin is 1500 µg/day (at least 3 tablets/day).

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Most cases of overdose recover after using supportive treatment. There may be drugs from the body by hemolysis.

There has been no report on the case of mecobalamin overdose.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using bazato, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurological: Mobility loss of coordination, vibration of the eyeball, fatigue, drowsiness, dizziness, edema, memory loss, anxiety, changing behavior in children from 3 to 12 years old, impotence. force, dizziness.

Neurological: Memory loss, loss of language, depression, mental change, mild paralysis, decrease or loss of sex, headache.

Cardiovascular: angina, hypotension, peripheral vascular disorders, suspense.

Neurology: Neurological paralysis, personality disorders, increased sensitivity, reduced exercise function, mental disorders. Eye.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Bazato medicine is contraindicated in the following case:

Hypersensitivity to Gabapentin, Mecobalamin, preparations of cobalamin, cobalt or any ingredients of the drug.

Be cautious when using

do not take the drug for too long if you do not see the response.

Do not arbitrarily take the drug because it can cause hematological reactions to patients lacking folat or hide signs for diagnosis.

Do not use high -dose mecobalamin in patients with mercury contacts or mercury compounds.

Caution for patients with a history of mental disorders, high blood pressure, cardiovascular disease, lung disease, impaired liver/ kidney function and hemolysis.

Patients may have secondary arrhythmia due to hypokalemia during treatment.

Monitoring plasma mecobalamine concentrations and index 3 peripheral blood cell line 3 - 6 months/time to determine the effectiveness of treatment.

The drug can cause false positive when testing proteinuria.

constantly drugs suddenly because it can increase the frequency of epilepsy.

Stop drugs if suspected of having Stevens-Johns syndrome.

The ability to drive and operate machinery

gabapentin can cause dizziness, fatigue, drowsiness, dizziness, vision loss, so it is necessary to drive kidneys while driving or operating machinery during medication.

Pregnancy

only use drugs when really necessary and benefits must be higher than the risk.

The period of breastfeeding

only taking the drug when really necessary and the benefits must be higher than the risk.

Interactive drug

When used simultaneously, gabapentin does not change the pharmacokinetics of commonly used anti -epileptic drugs such as carbamazepin, phenytoin, valproic acid, phenobarbital, diazepam.

Antimongic drugs reduce the bioavailability of gabapentin by about 20% due to the absorption, so it must be used at least 2 hours apart.

neomycin, aminosalicylic acid, antihistamine H2, omeprazol and colchicin reduces mecobalamine absorption.

contraceptives reduce mecobalamine levels in serum.

Chloramphenicol injection may reduce the effects of mecobalamin in the treatment of anemia.

Storage

Store in a dry place, under 30 ° C, avoid light.

Hasan - Dermapharm Co., Ltd. is one of the leading enterprises in research, development, production and commercialization of specialized pharmaceutical products meeting European quality standards. The production sector of the company includes: tablets, tablets, hard capsules, powder, nuggets, water medicine, ice cream, ointment. Tablets, tablets, hard capsules, powder and nuggets contain antibiotics of cephalosporin groups, and capsules, powder and nuggets containing microorganisms.

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