Benita Merap nasal sprays treat allergic rhinitis, nasal polyps (120 doses)

Dosage form Bottle
Specifications Budesonide
Ingredient Nose polyps, rhinitis, allergic rhinitis

Ingredient

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Composition information	Content
Budesonide	64mcg

Uses

indications

Benita drugs are indicated in the following cases:

Treatment of allergic rhinitis all year round and seasonal allergic rhinitis, rhinitis caused by vascular disorders. Anti -inflammatory effects such as inhibiting the release of intermediate substances that cause inflammation and inhibition of immune response through cytokin are important. The activity of Budesonid is measured by its affinity for glucocorticoid receptors about 15 times higher than the activity of Prednisolon. When using backup before stimulating the nose, Budesonid proves to protect against the penetration of eosinophilia and hypersensitivity.

With the dose of treatment, Benita does not cause any clinical changes at the basic level of cortisol in plasma as well as response to the stimulation of ACTH.

However, the decrease in plasma cortisol and urine related to the dose has been recorded in healthy volunteers after a short time of using Benita. Do not record the response relationship - dose through clinical trials in children with seasonal or year -round allergic rhinitis and adults with allergic rhinitis all year round.

pharmacokinetics

absorption:

Budesonid's body bioavailability in Benita is 33%, most of which absorb through the nasal mucosa.

In adults, the maximum plasma concentration after using 256 micrograms Budesonid in Benita is 0.64 nmol/l within 0.7 hours. The area under the curve shows the drug concentration over time (AUC) after using 256 micrograms budesonid from Benita is 2.7 nmol x hour/l in adults and 5.5 nmol x o'clock/l in children, this shows that in children, the body contact with glycocorticosteroid is higher.

Distribution and metabolism:

Budesonid has an integral distribution of about 3 l/kg. Combined with plasma protein is 85 - 90 %. Budesonid metabolizes the liver for the first time (90%) into low -glucocorticoid activity. Budesonid is not inactivated at the nose.

Era:

Metabolic substances are excreted through the kidneys in a constant form and a combination form. Only a significant amount of unchanged budesonid is found in urine. Budesonid has a high body clearance (0.9 - 1.4 liters/ minute), half -life in plasma after an average intravenous injection is about 2-3 hours.

Before taking Benita Merap nasal sprays treat allergic rhinitis, nasal polyps (120 doses)

How to use

Instructions for use:

Before the Benita spray is first used, the pipe must be pumped. Shake the bottle and spray into the air until a homogeneous spray is reached (about 8-10 doses). If after 24 hours to use the next dose, the pipe must be pumped. This time just spraying once into the air is enough.

clean the nose, shake the bottle. Open the protective lid.
Hold the medicine tube straight up.
Put the top of the pipe into the nostril and pump according to the prescribed dose. Similarly, pump the drug into the other nose.
Cover the protective lid.

Wash plastic parts regularly. Open the protective lid and remove the spray head into the nose. Wash these plastic parts in warm water. Let the plastic parts dry completely in the air before covering.

Dosage

Rhinitis:

Adults and children over 6 years old: The starting dose of 256 mcg/ day. Use once in the morning (128 micrograms on each nose) or divide evenly and at night (64 micrograms each nose in the morning and evening). When achieved efficiency, the lowest dose is required to control symptoms. The full effect is only achieved after a few days of treatment (rarely more than 2 weeks). Therefore, it is advisable to start treating seasonal contact rhinitis before contact with allergens.

Safe and effective in children under 6 years old has not been determined.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? When using high -dose benita for a long time, the effect of systemic glucocorticoids such as adrenal energy and adrenal medulla are likely to occur.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Benita, you may experience unwanted effects (ADR).

Common, ADR> 1/100:

On -site irritation, mild nasal bleeding, nosebleeds.

Uncommon, 1/1000

Evaluation, urticaria, dermatitis, rash, itching.

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Benita drugs contraindicated in the following cases:

Patients with hypersensitivity to Budesonid or any excipients of the drug.

Treatment for patients with fungal infections and nasal herpes.

Be cautious when used

When used in high doses, the systemic effect of glucocorticosteroids such as adrenal energy, adrenal medulla and child development retardation may occur. Should regularly monitor the development of children when treated for prolonged treatment with corticosteroids, regardless of the way. If there is a suspected retardation, medication must be reviewed.

Be cautious when treating patients with corticosteroids of systemic sugar to use Benita when there is a suspected hill - pituitary - adrenal shaft disorder. In these patients, the doses of corticosteroids should be carefully reduced, monitoring the function of the hypothalamus - pituitary - adrenal gland.

Patients with tuberculosis, impaired liver function.

Avoid contacting Benita with the eyes. If Benita is in contact with the eyes, should be washed immediately with water.

Safety and efficiency in children under 6 years old have not been determined.

Children should only use under the guidance of adults to ensure the right and right dose.

The ability to drive and operate machinery

does not affect the ability to drive and operate machinery.

Pregnancy

There is no adequate study when using drugs in pregnant women. Only used during pregnancy when really necessary.

The period of breastfeeding

budesonid is secreted through breast milk. However, in the treatment doses of the drug, it is unknown whether or not it affects the child. Benita can be used carefully during breastfeeding.

Medicine interaction

Simultaneously Ketoconazole 200 mg orally once a day with oral budesonid (3 mg only dose) increases on average 6 times the budesonid concentration in plasma.

When Ketoconazole is used after 12 -hour budesonid, the budesonid concentration increases 3 times. There is no information on this interaction when using budesonid nasal spray, but the budesonid level is also expected to increase significantly in these cases.

Avoid combining use because there is no data that allows the doses to recommend the nose. If the combination must be used, the distance used by Budesonid and Ketoconazole is as far as possible. It is also advisable to consider reducing the dose of Budesonid. Other powerful CYP3A4 inhibitors can significantly increase the concentration of budesonid in plasma.

Storage

In a dry place, less than 30 ° C, avoiding light. Not frozen.

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