Benoboston anti -allergy treatment for allergic rhinitis, acute urticaria (500 tablets)

Dosage form 500 tablets
Specifications Betamethasone, dexchlorpheniramine maleatamine
Ingredient Allergic rhinitis, urticaria, upper respiratory tract

Ingredient

Composition informationContent
Betamethasone0.25mg
Dexchlorpheniramine maleaty2mg

Uses

indications

benoboston drugs are indicated in the following cases:

  • Treatment of seasonal or year -round allergic rhinitis when not responding to a single or local corticosteroid resistance.

    betamethasone is a synthetic corticosteroid. Betamethasone has anti -inflammatory effects.

    dexchlorpheniramine

    dexchlorpheniramine maleaty, derivative of Alkylamine, antihistamine H1 has the sedative effect of the first generation. Like most other antihistamine resistance, chlorpheniramine reduces or loses the main effects of histamine in the body by competing in the clutches with reversing histamine in H1 receptors in the tissues on the gastrointestinal tract, vascular and respiratory tract.

    pharmacokinetics

    betamethasone

    absorption

    betamethasone is easily absorbed through the gastrointestinal tract.

    Distribution

    The ratio attached to protein is approximately 60%.

    Metabolism - Elimination

    betamethasone metabolizes in the liver and eliminates the kidneys. The sale time is about 36–54 hours.

    dexchlorpheniramine

    absorption

    Low bioavailability is about 25 - 50%. The peak concentration of plasma is about 2.5 - 6 hours after drinking. The effect of the drug lasts 4 - 6 hours.

    Distribution

    The ratio attached to plasma protein is 72%. Dexchlorpheniramine can pass the placenta and go into breast milk.

    Metabolism

    The drug is metabolized through the liver. The metabolites include Desmethyl - Didesmethyl - Chlorpheniramine and some unknown substances.

    Elimination

    Kidney elimination. The sale time of the drug is 14-25 hours. In patients with liver failure, renal failure may increase the sale time of dexchlorpheniramine.

  • Before taking Benoboston anti -allergy treatment for allergic rhinitis, acute urticaria (500 tablets)

    How to use

    oral medication.

    Dosage

    only for adults and children over 6 years old.

    Adults and children over 12 years old: 1 capsule x 3-4 times/day.

    Children 6 - 12 years old: 1/2 tablets/time x 2 times/day (used in the morning and evening).

    The dose can be reduced to 1 tablet every 2 days, which is the lowest dose effectively.

    The time for acute urticaria symptoms is no more than 10 days. Therefore, when stopping treatment, there is no need to reduce the dose slowly.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? The effectiveness of the jurisdiction has not been seen in cases of overdose.

    Overdose treatment includes symptomatic treatment and supportive treatment. Do not use stimulants. Hypertension may be used to treat hypotension. The seizures are best processed with drugs that reduce the activity that has short -term effects like Thiopental. Maintain adequate water supply and control electrolytes in serum and urine, paying special attention to the balance of sodium and potassium. Treatment of electrolyte imbalance if necessary.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    When using benoboston, you may experience unwanted effects (ADR).

    betamethasone

    The undesirable effects of Betamethasone are largely related to large doses, prolonged treatment time or for months.

  • Water disorders and electrolytes: Hypotension, metabolic alkaline infection, water retention, arterial hypertension, congestive heart failure.
  • metabolism and endocrine: Cushing syndrome caused by drugs, ACTH secret inhibitors, sometimes cause permanent adrenal atrophy, reduced glucose tolerance, hidden diabetes, inhibiting children's growth, irregular menstrual periods.

    Muscle muscle: muscle weakness or atrophy (due to hypertension), osteoporosis, pathological fracture, (especially spondylosis), femoral necrosis. digestive: gastric ulcer, intestines, perforation and gastrointestinal hemorrhage, acute pancreatitis especially in children.

    Skin: Acne, bleeding, bruising, hype, long healing wounds.

  • Mental: Common: excitement, insomnia, excitement; rarely: manic, delirium, convulsions (all or local); Depression state after stopping the drug.
  • Eyes: cataracts, glaucoma.
  • dexchlorpheniramine

  • Neurological effects: sedation, drowsiness (this manifestation is clearer when starting treatment), anti -cholinergic effects such as mucosal dryness, constipation, eye regulation disorders, pupils, hitting chest drum, risk of urinary retention, loss of balance, dizziness, memory reduction or centralized decrease (common in elderly people) Insomnia (especially in infants).
  • allergic reactions: Red, eczema, itching, hemorrhage, can get huge urticaria, edema, rarely have angioedema, anaphylaxis. Hematology: leukopenia, neutropenia, thrombocytopenia, hemolytic anemia.

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    contraindicated

    Benoboston drugs are contraindicated in the following cases:

  • Hypersensitivity to any ingredient of the drug or with similar structural drugs.
  • Because drugs contain betamethasone should be contraindicated in the following cases:

  • Any infection.
  • Infections caused by some viruses (including hepatitis, chickenpox, herpes, shingles).
  • Unsontrollable mental states by treatment.
  • Living vaccine.

    Because the drug contains dexchlopheniramine, it is contraindicated in the following cases:

  • The risk of closing angle glaucoma.
  • Risk of urinary retention related to prostate urethral disorders.

    The form of preparation is not suitable for children under 6 years old.

    This drug is not recommended for:

  • Women who are breastfeeding.
  • Combined with peak -causing drugs (except anti -arrhythmia).
  • Be cautious when using

    Caution with Betamethasone

    The drug is used carefully for tuberculosis patients, gastrointestinal ulcers, mental illnesses, herpes simply caused by herpes, cardiovascular disease, including high blood pressure, thrombosis, cataracts under the following bags, diabetes, osteoporosis, liver disease, infections, narrow -angle glauca, obstruction of the pylorus, prostate enlargement or bladder obstruction.

    The drug is also used to be used carefully for patients with acute myocardial infarction before (there is a report on cardiac arrest).

    When you want to stop the drug, you must gradually reduce the dose and replace it with other medications more appropriately.

    Average doses and high doses of corticosteroids increase blood pressure, keep salt and water, increase potassium elimination. Consider a diet that limits salt and provides more potassium. All corticosteroids increase calcium elimination.

    When using corticosteroids in children, severe viral infections such as seasonal perching and measles may be worse due to the effect of inhibiting the immunosuppressure of the drug.

    During the treatment with corticosteroids, patients should not get seasonal vaccinations. Immune measures should not be applied for patients taking corticosteroids, especially when used in high doses because of the neurological complication and lack of antibody response.

    has not determined the safety and effectiveness of the drug in children under 3 years old.

    Should closely monitor the growth and development of children because corticosteroids can affect the growth and inhibition of endogenous corticosteroids in these patients.

    Using Cortisteroids is at risk of urticaria. Therefore, the treatment of chronic urticaria symptoms is not shown to be effective.

    Corticosteroid treatment may increase the risk of infections, especially bacteria, yeast and parasites. The appearance of malignant eelworm is a significant risk. All subjects from the circulation area (tropical, subtropical, southern Europe) need to check the parasites and have the method of eradication before corticosteroid treatment. Before starting treatment, it is important to eliminate internal infections, especially tuberculosis, and monitor the appearance of infectious diseases during treatment. In the case of long -term tuberculosis, tuberculosis prophylaxis is necessary if there is a significant sequelae due to radiation, and if it is not certain that a 6 -month treatment has been performed with Rifampicin.

    The use of corticosteroids should be closely monitored, especially in the elderly, patients with ulcerative colitis (at risk of perforation), patients with recent intestinal connectivity, liver failure, kidney failure, osteoporosis, muscle weakness.

    Be cautious with dexchlopheniramine maleate

    Elderly patients in the case:

  • Easy to hypoguratically posture, dizziness, drowsiness.
  • Chronic constipation (risk of intestinal paralysis).
  • Prostate hypertrophy.
  • Patients with severe hepatic or renal failure, due to the risk of drug accumulation.

    Do not recommend the use of alcoholic beverages and drugs during treatment.

    Caution with excipients

    The drug contains lactose. Do not use for patients with rare genetic problems with galactose, lactase deficiency, or Glucose - Galactose.

    The drug contains starch starter, suitable for patients with fat diarrhea. Do not use for patients allergic to starch (except in the case of fat diarrhea).

    The ability to drive and operate machinery

    Because the drug has an unwanted effect such as causing drowsiness, blurred vision, dizziness, it is cautious when driving, operating machinery, working on high or other cases.

    Pregnancy

    Because children born from mothers use corticosteroids during pregnancy suffering from adrenal and safety function of this drug in pregnant women who have not been determined, the use of this drug for pregnant women, nursing women or women during reproductive period should consider the benefits of treatment and the ability to endanger the mother and the mother.

    The period of breastfeeding

    The use of this medication for breastfeeding women needs to consider the benefits of treatment and the ability to endanger the mother and infant.

    Drug interaction

    betamethasone

    Twisted drugs (Astemizol, Bepridil, Erythromycin intravenously, Halofantrin, Pentamidine, Sparfloxacin, Sultopride, Terfenadine, Vincamine, Amiodarone, Bretylium, Disopyramide, Quinidine, Sotalol): Hypotension as well as the heart of the heart of the heart and extended the QT from the QT from QT. First is the factor that contributes to the torsion. Therefore, the vertex can occur when used with betamethasone in the case of hypokalemia.

    acetylsalicylic: corticoid can reduce the concentration of salicylate in the blood. Be careful when combining acetylsalicylic acid with corticosteroids in case of reducing blood prothrombin.

    Oral anticoagulant: Corticosteroids simultaneously used with anticoagulants of cooumarin may increase or decrease the anticoagulant effect, so the dose can be adjusted.

    Other blood potassium hypoglycemia: simultaneous use of corticosteroids with diuretics that cause potassium loss (such as thiazide, furosemide) can lead to hypotension. Increased risk of hypokalemia when used with amphotericin b.

    Digitalis: Concentrated use of corticosteroids with glycoside may increase the possibility of arrhythmia or toxicity of digitalis and hypotension.

    Heparin injected: Heparin worsens the risk of bleeding due to corticosteroids (stomach mucosa, fragile blood vessels) when taking high doses or lasts more than 10 days. Coordination must be explained and strengthened supervision.

    Enzyme induction substances: Concentrated with phenobarbital, phenytoin, rifampin or ephedrine may increase corticoid metabolism, thus reducing the effect of corticosteroids.

    insulin, metformin, sulfonylurea: hyperglycemia with ceton infection (because corticosteroids reduce carbohydrate intolerance). The patient should be warned and increased blood and urine monitoring, especially when starting to treat. The dose may be needed during treatment with corticosteroids and after stopping the drug.

    Isoniazid: reduces the plasma isoniazid levels.

    Popular effect on the stomach - intestines (salt, oxide and hydroxide of aluminum, magnesi and calcium): reduces the absorption of glucocorticoids. Do not use with glucocorticoid (at least 2 hours away from the dose time if possible).

    Anti -blood pressure: Reducing the effect of hypotension.

    Interferon alpha: Inhibiting the operation of interferon.

    Living vaccine: The risk of disease outbreak, can be fatal. This risk is increased in patients who have been inhibited immunology due to their other pathology. Replace with an inactive vaccine when possible (polio vaccine).

    Patients taking both corticosteroids and estrogen should be monitored for excessive effects of corticosteroids.

    Increase ulcer and gastrointestinal bleeding when sharing nonsteroidal anti -inflammatory drugs with corticosteroids.

    dexchlorpheniramine

    Alcohol: Increases the sedative effects of antihistamine H1.

    Other central neurological inhibitors (sedatives, barbiturates, benzodiazepine, clonidine and related antidepressants, sleeping pills, opioid derivatives (analgesic and cough medications), methadone, Anxioltic): Increases depression on the central nervous system. Affect the ability to drive and operate machinery.

    Atropine and other Atropine (3 -round antidepressants, anti -cholinergic drugs, Atropine anti -spasms, disopyramide, phenothiazine sedatives): increase the side effects of atropine such as urinary retention, constipation, dry mouth.

    Storage

    Where dry, less than 30 ° C, avoid light.

    Other drugs

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