Bepracid 20mg Pymepharco Treatment of gastroesophageal reflux, gastric ulcer - duodenum (1 blister x 14 tablets)

Dosage form Box of 1 blister x 14 tablets
Specifications Rabeprazole
Ingredient Peptic ulcer, gastroesophageal reflux, Zollinger-Eleson syndrome

Ingredient

Composition information	Content
Rabeprazole	20mg

Uses

indications

beepacid drugs are indicated in the following cases:

Treatment of gastroesophageal reflux disease.

Mechanism of action: Rabeprazol Natll belongs to acid -secreting drugs, Benzimidazol's derivatives, does not try to try cholin resistance or antihistamine H2 but inhibit acid secretion in the stomach by inhibiting enzyme enzyme H+/K+ -Aatpase (Proton pump).

Acid secretion effect: Acid resistance on 1 hour after taking a dose of 20mg Rabeprazol sodium, the average inhibitory effect on stomach acid for 24 hours of Rabeprazd sodium is 88% after taking the first dose.

Effects on serum gastrin: In patients with sodium rabeprazol 1 -time/day up to 8 compliance to treat ulcers or esophagus corrosion and in patients up to 52 weeks to prevent the recurrence of the disease, the average concentration of Gastrin when hungry increases related to the dose.

Dynamic pharmacokinetics

absorption

Rabeprazol is not durable in acidic environment. The absorption occurs only after the pills leave the stomach. Quick absorption, shallow peak rabeprazol in blood (CMAX) reached about 3.5 hours after a dose of 120mg. CMAX and AUC ratio with doses of 10 - 40mg. The absolute bioavailability of a 20 mg oral dose is about 52% due to metabolism largely before the system circulation. Semi-cancellation time in plasma is about 1 hour (0.7-1.5 hours), the body clearance is 283 ± 98ml/min. No interaction with food.

Distribution

97% associated with plasma protein.

transformation

Metabolized through the cytochrom P450 system (CYP450) 2C19 and 3A4 of the liver.

Elimination

90% of the dose is excreted in urine in two forms of metabolism: the form of Mecapturic Acid (M5) and the form of carboxylic acid (M6), and two other unknown metabolites. The rest of the tlm dose is seen in the feces.

Before taking Bepracid 20mg Pymepharco Treatment of gastroesophageal reflux, gastric ulcer - duodenum (1 blister x 14 tablets)

How to use

beepracid is used by oral. Swallowing the whole tablet, do not chew or crush. Drink in the morning before eating.

Dosage

Gastroesophageal reflux disease - severe esophagus: normal dose 20mg/time/day for 4 - 8 weeks. Do not use more than 12 months.

Stomach - duodenal ulcerative: 20mg/day for 4 - 8 weeks for duodenal ulcers and 6 -12 weeks for stomach ulcers.

Zollinger - Ellison syndrome: The starting dose of 60mg/time/day, adjusting the dose according to the patient's response. The dose may increase to 120mg/day. When the daily dose is greater than 100mg should be divided into 2 times.

Eliminating H.pylori: Combined treatment for 7 days according to the regimen: (1 tablet bepra61d 20 + 1000mg Amoxicillin + 500mg Clarithromycin) x 2 times/day.

Patients with renal failure, liver failure: No dose adjustment. Applicable only in light and medium cases.

Children: Do not ask for use for children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? There are no clinical signs or symptoms related to overdose.

Unknown antidote to Rabeprazol's specific detoxification. In the case of overdose, it is necessary to treat symptoms and support the total status.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Bepracid 20mg, you may experience unwanted effects (ADR).

Common: headache or diarrhea, skin rash. It is possible to encounter cases of itching, dizziness, fatigue, constipation, nausea, flatulence.

Instructions on how to handle ADR: notify the unwanted physician when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Bepracid drug 20mg contraindicated in the following cases:

Patients with hypersensitivity to drug ingredients or benzimidazol derivatives.

Be cautious when used

Before using Rabeprazol should diagnose malignant stomach or malignant gastric ulcer. Long -term treatment patients should be checked regularly. There is no experience in treating children. Precautions when used in patients with severe liver dysfunction. Using high -dose and prolonged rabeprazol (over 1 year) may increase the risk of fractures associated with osteoporosis.

The ability to drive and operate machinery

No information.

Pregnancy

Experience using Rabeprazol for pregnant women is limited.

The period of breastfeeding

Experience using Rabeprazol breastfeeding is limited.

Interactive drug

Stomach pH drugs: Having the ability to interact with pharmacokinetics. The simultaneous use of sodium rabeprazole with ketoconazole or itraconazole can significantly reduce the concentration of antifungal drugs in plasma.

Liquid antacid agents: Rabeprazol does not interact.

warfarin: simultaneous use of rabeprazol with warfarin increases thrombin time causing abnormal bleeding can lead to death.

cyclosporin: simultaneously using rabeprazol with cyclosporin may increase the maximum concentration of cyclosporin.

Methotrexate: Concomitant use of rabeprazol with methotrexate may increase and prolong the concentration of methotrexate and its metabolites in serum.

Storage

A cool place, temperature below 30 degrees C.

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