Betalgine Nadyphar drugs for vitamin B1, B6, B12 (80 tablets)

Dosage form Hard capsules
Specifications Vitamin B1, Vitamin B6, Vitamin B12
Ingredient Fatigue, sciatica, migraine, rheumatism, back pain, body aches, B vitamins

Ingredient

Composition information	Content
Vitamin B1	125mg
Vitamin B6	125mg
Vitamin B12	125mcg

Uses

indications

Betalgine drugs are indicated in the following cases:

Treatment of lack of vitamins B1, B6, B12.

Sales of rheumatism or nerves.

Nutrition -related conditions such as weakness, anorexia, anemia, nursing period.

Pharmacoki

Combining 3 vitamins B1, B6, B12.

Vitamin B1

Thiamin actually does not have pharmacological effects even at high doses. Thiamin has a physiological activity: Thiamin Pyrophosphate, is a carbohydrate metabolic coenzyme that is responsible for carboxyl reduction of Alpha-Cetoacids such as Pyruvat and Alpha-Cetoglutarat and in using pentose in the Hexose Monophosphate cycle. Thiamin demand directly related to carbohydrate and metabolic speed; When Thiamin deficiency, the oxidation of alpha-Cetoacids is affected, increasing the level of pyruvate in the blood, which helps to diagnose vitamin B1 deficiency.

Thiamin deficiency causes Beriberi (numbness), manifested on the nervous system (dry beriberi) such as peripheral neuritis, sensory disorders. Cardiovascular symptoms due to thiamin deficiency include exertion, chest drum, tachycardia and other disorders are found to be manifested by electrocardiogram changes and heart failure with high "wet beriberi" cardiac arc.

Vitamin B6

Vitamin B6 when entering the body transforms into pyridoxal phosphate and partly into pyridoxamin phosphate. These two substances act as coenzymes in the metabolism of protein, glucid and lipid. Pyridoxin participates in the synthesis of gamma-aminobutyric acid (GABA) in the central nervous system and participates in Hemoglobin synthesis. Pyridoxine deficiency occurs when absorption disorders (in case of alcoholism, burns, intestinal diseases, bacterial infections), disorders caused by drugs (patients treated with izoniazid, cycloserin). Pyridoxin deficiency can lead to iron -cell anemia, peripheral neuritis.

Vitamin B12

Vitamin B12 has the effect of hematuria. In the human body, it forms the active coenzymes are methylcobalamin and 5-caleoxaadenosylcobalamin, which is essential for cells to copy and grow. Methylcobalamin is needed to create methionine and conduct as s-adenosylmethionin from homocystein. In addition, when vitamin B12 levels are not enough, it will cause impaired function of some other types of folic acid in the cell.

Hematology abnormalities in people with vitamin B12 deficiency are due to this process. 5-damoxaadenosylcobalamin is essential for the isomorphic, converting L-methylmalonyl coa into success. Vitamin B12 is essential for all tissues with strong cell growth such as hematoma, small intestine, and uterus. Vitamin B12 deficiency also causes neuron cancellation.

pharmacokinetics

vitamin B1

After drinking, Thiamin is absorbed through the gastrointestinal tract due to the positive transportation depends on Na+. When Thiamin concentration in the gastrointestinal tract, passive diffusion is also important. In adults, about 1 mg of Thiamin is completelyeled every day in tissues and this is the minimum amount needed daily.

When absorbed at this level, very little or no thiamin is eliminated through the urine, when the absorption exceeds the minimum demand, the first Thiamin warehouse in saturated warehouses. After that, the excess amount will be eliminated through the urine in the form of intact thiamin molecules. When the thiamin absorption increases further, excretion in the form of unprocessed thiamin will increase.

Vitamin B6

is quickly absorbed through the gastrointestinal tract. After drinking, the drug is mostly reserved in the liver, partly in the muscle and brain. Pyridoxin excreted mainly through the kidneys in the form of metabolism. The amount of introduction, if exceeding the daily needs, most excreted in the form of unchanged.

Vitamin B12

Vitamin B12, after oral, is absorbed through the intestine, mainly in the ileum in two mechanisms: the passive mechanism when the amount is high and the active mechanism, allowing the absorption of vitamin B12 in physiological doses; The main storage in the liver and eliminated through bile. About 3 μg of cobalamin is deducted through the daily bile, of which 50 - 60% are the derivatives of cobalamin that cannot be reabsorbed.

Before taking Betalgine Nadyphar drugs for vitamin B1, B6, B12 (80 tablets)

How to use

oral medication.

Dosage

According to the instructions of the physician, average:

Adults

1 - 2 capsules/time, 2 times a day.

Children

as directed by the doctor.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

Related to pyridoxin:

Symptoms

pyridoxin is often considered non -toxic, but when high doses (such as 2 g/day or more) lasts (over 30 days) can cause sensory neurological syndrome, loss of coordination. Neuropathy syndrome may be caused by anatomical lesions of the nodes on the spinal cord nerve. The manifestation of losing the sense of the position and tremor of the limbs and the loss of the sensory movement gradually. Touching, distinguishing hot and cold and pain less. No weakness.

Handling

Stop using pyridoxin. After stopping pyridoxin, neurological dysplasia gradually improves and long -term monitoring is good for recovery, can stop the drug for up to 6 months for the sensory nervous system to return to normal.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Betalgine, you may experience unwanted effects (ADR).

Regarding vitamin B1 (rare)

Sweating, hypersensitivity.

Acute hypertension.

The dose of 200 mg/day, lasting for more than 2 months can cause severe peripheral neuropathy, progressing from unstable form and numbness to the numbness and clumsy hands, this condition can recover when stopping the drug.

Rare: skin rash, itching, urticaria, redness, nausea, vomiting.

Anaphylaxis reactions, fever, headache, dizziness, bronchospasm, mouth angio - Most.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Betalgine drugs contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug.

malignant.

Pregnant, lactating women.

Be cautious when using

Caution for people with allergies (asthma, eczema).

Related to Vitamin B6: Taking a dose of 200 mg daily, lasting over 30 days can cause vitamin B6 dependence syndrome, lasting for more than 2 months can manifest neurotoxicity (such as severe peripheral neuropathy and severe sensory neurological disease).

The ability to drive and operate machinery

does not affect the driver and operate machinery.

Pregnancy

Not used for pregnant women because it can cause a symptom of vitamin B6 in infants (related to vitamin B6, when high doses).

The period of breastfeeding

is not used for breastfeeding women because it can cause a dependence of vitamin B6 in infants (related to vitamin B6, when high doses).

Interactive drug

involving vitamin B6

pyridoxin reduces the effects of levodopa in the treatment of Parkinson's disease, the dose of pyridoxin 200 mg/day can cause 40-50% reduction in phenytoin and phenobarbital concentration in patients.

pyridoxin gently reduce depression in women who take birth control pills.

hydralazin, isoniazid, penicilamin, oral contraceptive drug increases the demand for pyridoxin.

Regarding vitamin B12

neomycin, aminosalicylic acid, antihistamine H2 and Colchicin antibiotics reduce the absorption of vitamin B12.

Storage

Store at a temperature not exceeding 30 ° C, in a dry place, avoiding light.

Other drugs

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