Betaserc 16mg Abbott treatment for vestibular disorders (3 blisters x 20 tablets)

Dosage form Box of 3 blisters x 20 tablets
Specifications Betahistine
Ingredient Tinnitus, vestibular disorders, headaches, dizziness

Ingredient

Composition information	Content
Betahistine	16mg

Uses

Indications

Ménière syndrome is determined by the following main symptoms:

Dizziness (dizzy dizziness with nausea/vomiting). Yen).

Detailed description below shows how the main active ingredient of Betaserc works. Ask your doctor if you need more explanation.

Only partly understood the new acting mechanism of Betahistine. There are some reasonable hypotheses that have been confirmed by animal studies and human data:

betahistine acts on the histamine secretion

Betahistine plays both roles as part of the H1 h1 receptor receptor as well as antagonist in the H3 histamine receptor in the nerve tissue and has a negligible activity of H2 receptor.

betahistine increases metabolism and histamine secretion thanks to the sealing of H3 receptors of the synap and induces the reverse regulation of the H3 receptor.

Betahistine can increase blood circulation to the cochlea as well as the whole brain

Pharmacological experiments on animals show that there is improvement in blood circulation in the pattern of the inner ear pattern, possibly due to relaxation of the capillary sphincter of the inner ear circulation.

Betahistine is also shown to increase brain blood circulation in humans.

betahistine makes it easy to make vestibular adjustment: Betahistine promotes the recovery of vestibular after a animal on the one -side nerve surgery, thanks to easy to make and increase the rehabilitation of the central vestibular adjustment. This effect is characterized by regulating metabolism and histamine secretion through the intermediaries of antagonism in H3 receptor. In humans, the recovery time after nerve surgery also decreases when treated with betahistine.

Betahistine changes nerve impulses in vestibular multiplication

Betahistine also has the effect of inhibiting the dosage on the tail of the neuron in the side and the middle nucleus of the vestibular money.

Pharmacological properties have been proven in animals that can contribute to Betahistine's treatment benefits in the vestibular system.

The effect of Betahistine has been shown in studies in patients with dizziness in the vestibular and Ménière disease and has been shown by improving the condition and frequency of dizziness.

pharmacokinetics

Detailed description below shows how the metabolism of the active ingredient of Betaserc in the body. Ask your doctor if you need more explanation.

absorption

When drinking, Betahistine absorbs strongly and almost entirely through all segments of the digestive tube. After absorption, this drug will metabolize rapidly and almost completely let 2-Pyrylacetic acid lose pharmacological activity. Betahistine concentration in plasma is very low.

Therefore, all pharmacokinetic analysis is based on measurement 2 - PAA in plasma and urine.

When you eat full, see the cmax of the drug will be lower than when fasting. However, the complete absorption of Betahistine is equivalent to both hunger states, showing that food only slows the absorption of Betahistine.

Distribution

percentage of betahistine is linked to plasma proteins below 5%.

Metabolism

After absorption, betahistine is quickly metabolized and almost completely into 2 - PAA (without pharmacological activity).

After taking betahistine, concentration 2 - PAA in plasma (and urine) reaches the maximum after 1 hour drink and a half after about 3.5 hours.

Elimination

substance 2 - PAA quickly excreted through the urine. With doses between 8 and 48mg, about 85% of the first dose is re -collected urine. The elimination of mother betahistine through the kidney or stool is less meaningful.

linear

The recovery speeds are constant when given in the area 8 - 48mg, proving that the pharmacokinetics of Betahistine are linear and shows that the metabolic path is not saturated.

Before taking Betaserc 16mg Abbott treatment for vestibular disorders (3 blisters x 20 tablets)

How to use

You should use Betaserc 16mg as directed by your doctor and check the information on the label for instructions on the exact medication. In particular, you do not use the drug in low doses, high or longer than the specified time.

You can take Betaserc 16mg with or not with food. However, you can take the drug with food to reduce the stomach irritation. Besides, you need to take the tablet with a full glass of water. You take medicine during or after meals.

Dosage

Adults

The adult dose is 8 - 16mg x 3 times/day.

The doctor will adjust the dose depending on the response of each patient with the drug. There are indications for treatment right from the beginning of the disease that will prevent the progression of the disease and/or prevent hearing loss in the slow -moving phases of the disease.

Elderly: Despite the limited data from clinical studies in this patient group, extended post -marketing experiences show that the adjustment of the dose in this patient is not necessary.

Renal failure and/or liver failure: There are no specific clinical studies in this patient group, but according to the post -marketing experience, the adjustment of the dose seems unnecessary.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Some patients have mild to medium mild symptoms such as nausea, drowsiness and abdominal pain when taking doses to 640mg. More serious complications include, convulsions and complications of lungs and hearts encountered in cases of intentional overdose when used in combination with other drugs to overdose.

Overdose treatment: Actively monitor for timely monitoring measures. There is no specific antidote. Overdose treatment includes standard support measures.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Like all drugs, Betaserc 16mg may have side effects. If you have any side effects that are not specified in this tutorial or have a serious side effect, please notify your doctor or pharmacist.

The following unwanted effects are studied with frequency specified in patients treated with betaserc in placebo -controlled clinical tests: common (from 1 to 10 cases in 100 treated patients).

Gastrointestinal disorders:

Common: Vomiting and indigestion (digestible indigestion).

neurological disorders:

Common: headache.

Add to events that have been reported in clinical trials, the following unwanted effects are voluntarily reported during the use of post -marketing and in specific documents. The frequency cannot be estimated from available data and therefore classified as "unknown".

immune system disorders:

Allergic (sensitive) including serious (hypersensitivity) allergic reactions can cause shortness of breath, swelling of the face and neck, dizziness.

Gastrointestinal disorders:

Mild stomach pain (for example: vomiting, stomach pain, intestinal, swelling and blistering abnormally). These effects are often lost when taking the drug during meals or reducing the dose.

Disorders of skin and adipose tissue:

In some very rare cases, there are hypersensitivity reactions in the skin, especially sudden swelling (nervous edema) in the neck or limbs, urticaria, rash and itching.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Do not use betaserc if allergies (hypersensitivity) with active ingredients or any excipients of the preparation or if adrenal tumors are known as chromium cell tumors.

Precautions when using

If you have bronchial asthma or have a history of stomach ulcer (gastrointestinal tract), the doctor will have to monitor you carefully when taking this medication.

The ability to drive and operate machinery

betahistine is indicated with Morbus Meniere (Ménière) and dizziness. Both of these diseases can have a negative effect on the ability to drive and operate machinery. In clinical studies specially designed to investigate the ability to drive and operate machinery, Betahistine does not cause negligible or negligible effects.

Pregnancy

Please consult your doctor or pharmacist before you take the drug during pregnancy.

There is no adequate data related to the use of betaserc in pregnant people. Studies on animals are also not sufficient to indicate the effect of the drug during pregnancy, or with the development of embryos/fetuses, with the birth and the development of newborns, in this regard, it is unclear potential for embryo and newborn baby. Do not use betaserc during pregnancy, before the doctor feels really needed.

Breastfeeding period

Unknown excretion of betahistine through breast milk. There are no studies on animals about the excretion of Betahistine through milk. Recommendation should not be used during breastfeeding.

For more information, ask your doctor about the importance of the drug for you, the benefits of breastfeeding and the potential risk to children.

Drug interaction

There has been no interaction research on the living body (in vivo). The data is based on a laboratory (in vitro) that does not see the inhibition of cytochrom P450 enzymes on the living body.

If you are taking Monoamine - oxidase inhibitors (Maois, including sub -type B (for example, Selegiline)), which is used to treat depression or Parkinson's disease, you should notify your doctor because these drugs can increase the effect of Betaserc.

Betahistine has a structure similar to histamine, drug interaction between betahistine and antihistamine can affect the effectiveness of one of these drugs. Please inform your doctor if you are taking antihistamine before taking Betaserc 16mg.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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