Betriol 15g VCP skin ointments treated on the spot for stable psoriasis psoriasis

Dosage form Tube
Specifications Calcipotriol, betamethason
Ingredient VCP Pharmaceutical Joint Stock Company

Ingredient

Composition informationContent
Calcipotriol
Betamethason

Uses

indicators

Betriol skin ointment indicated on the spot for stable psoriasis psoriasis.

Pharmacokology

betamethason: Pharmacological group: glucocorticoid. ATC code: dotac01

betamethason is a synthetic corticosteroid, topical corticosteroids such as betamethason dipropionate have anti -inflammatory, itching, vasodilation and immunosuppressive inhibitors. However, the anti -inflammatory mechanism of topical corticosteroids has not been clearly defined.

Calcipatriol: Pharmacological group: Psoriasis treatment. ATC code: D05AX52

As a synthetic substance similar to vitamin D, in vitro data shows that calcificationriiol differentiate and prevent the proliferation of horn cells. This is the basis in the effectiveness of psoriasis treatment.

Dynamic pharmacokinetics

Clinical trials with ointments containing Calcipotriol and Betamethason Dipropionate (Daivobet) have noted that there is a whole body absorption of these two active ingredients less than 1% (dose 2.5g) when used for normal skin (area of ​​625cm) for 12 hours. For psoriasis skin and tape increases the absorption of betamethasone, up to approximately 24%.

After absorbing the whole body, Calcipotriol and Betamethasone rapidly metabolize. Plasma protein bonds about 64%. The sale time in plasma after intravenous injection is about 5-6 hours.

betamethason is specially metabolized in the liver, but it is also partially metabolized in the kidney by the ester glucoronate and sulfate process and excreted mainly through urine.

Calcipotriol is metabolized mainly in the liver and excreted through bile.

Before taking Betriol 15g VCP skin ointments treated on the spot for stable psoriasis psoriasis

How to use

Clean and dry the damaged skin, apply a thin layer of drugs to injured places. Make sure the drug is covered evenly.

Wash your hands after using the drug, except for the use of the drug for the hands.

Dosage

adults

Use on the skin: Apply a sufficient amount of medication to the sick skin. One day.

The recommended treatment roadmap is 4 weeks. There was a monitoring of repeated treatment containing Calcipatriol and Betamethasone for 52 weeks. If you need to continue treating after 4 weeks or repeat treatment, it is necessary to have appropriate evaluation and monitoring during treatment.

The maximum daily recommended dose is 15g.

The area of ​​the skin using the drug should not exceed 30% of the multi -body area.

In case of liver failure or renal failure: There is no clinical assessment in these patients.

For young children: The safety and effectiveness of the drug has not been determined with children under 18 years old. There are current research data for children aged 12 to 17, but no recommended dose is established.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? However, after stopping the medication, blood calcium concentration returns to normal.

Large doses (large amount of drug, prolonged time or in closed skin, many folds, icy ice after use) can lead to secondary adrenal insufficiency (due to the effect of betamethasone in drug composition).

The adrenal gland function may recover itself after taking the drug, but it may also be necessary to treat it if necessary. In case of chronic poisoning with corticosteroid (betamethasone), it is necessary to stop the drug.

In a report on the treatment of body red psoriasis, patients use overdose with 240g weekly, lasting 5 months (about 34g per day, while the recommended dose is 15g per day), developing Cushing syndrome during treatment and pustular psoriasis right after the stop treatment.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Betriol skin ointment, you may experience unwanted effects (ADR).

Infection ability:

  • Uncommon (1/1000
  • Rare ADR

    The immune system:

  • Rare ADR

    Metabolism and nutrition:

  • Rare ADR

    On the skin and soft tissue:

  • Common (1/100 Uncommon (1/1000
  • rare (1/10000

    Use drugs for children:

    There is no recommendation for children under 18 years of age.

    In an uncontrolled test report, 33 patients aged 12-17 years old with psoriasis psoriasis are treated with daivobet ointment "for 4 weeks at a dose of 50g per week. There is no new unwanted effect that has been recorded and there is no sign of any concern related to the effects of general corticosteroids.

    (*daivobet: ointment containing calcoriiol 50kg/g and betamethasone 0.5mg/g)

    Unwanted reactions related to betamethason:

    Local reactions may occur, especially for prolonged use including: Skin atrophy, stretch marks, folliculitis, skin color change, dermatitis around the mouth, contact dermatitis, under skin capillary dilatation, loss of skin pigmentation, milia.

    Treatment of psoriasis common with corticosteroids is at risk of developing pustular psoriasis.

    The whole body reaction due to local corticosteroids in adults is rare, but may encounter and the level may be very dangerous.

    There are symptoms: adrenal inhibition, cataract, infection, loss of blood sugar in patients with diabetes, increased intraocular pressure. The whole body reaction occurs more often when used for prolonged use; Closed wound after treatment, used on large skin or sealed skin (many folds).

    Unwanted reactions related to calcipotriol:

    Mainly local reactions such as itching, skin irritation, burning sensation, dry skin, rash, skin redness, dermatitis, eczema, psoriasis worsening, skin sensitive to light.

    Some hypersensitivity reactions are very rare, such as angels or facial edema.

    Systemic reaction may appear if overdose is hypercalcemia or calcium urinary, but calcium concentration will return to normal after taking the drug.

    • Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Betriol skin ointment is contraindicated in the following cases:

    Cases of hypersensitivity to any ingredients of the drug.

    Cases of other psoriasis such as body red psoriasis, peeled psoriasis and pustules.

    The drug contains calcificationriol, contraindicated for people with blood calcium metabolic disorders.

    The drug contains corticosteroids, contraindicated with infected skin conditions, fungi, viruses, parasites, skin manifestations related to tuberculosis, dermatitis around the mouth, skin atrophy, stretch marks, subcutaneous hemorrhage or capillary under the skin vulnerable, fish scales, acne, red face syndrome, skin ulcers, burns and deep wounds.

    Caution when using

    The impact on the endocrine system:

  • The drug contains strong active corticosteroids (group III), to avoid use in combination with other corticosteroids. The body's adverse reactions are related to the treatment of generalized corticosteroids such as adrenal inhibition or impact on blood sugar control in diabetes patients with local corticosteroid use due to systemic absorption.

    Effects on calcium metabolism:

  • The drug contains calcableriol, the daily overdose of the daily (15g) can cause hypercalcemia. Calcium concentration will return to normal after use. The risk of hypercalcemia is very low if the treatment recommendations are followed.

    • Unwanted effects on the spot:

  • It is necessary to avoid using another preparation containing Corticosteroids. Wash your hands after using the drug (except for the use of the drug for the hands) to avoid adhesion to other areas.

    • Secondary infection:

  • If the lesions appear infections, fungi or viruses due to the impact of corticosteroids, they should take control measures, if the condition does not improve, they need to stop using corticosteroids.

    • Stop treatment:

  • The use of corticosteroids in the treatment of psoriasis can cause pustulent psoriasis or more severe relapse after treatment. Therefore, it is necessary to continue monitoring after stopping the drug.

    • Leading use:

  • The long -lasting use of corticosteroids increases the risk of unwanted and unwanted effects on the spot and the whole body.

    Other simultaneous therapies:

  • On the market, there is a gel -shaped circulation of gel -containing Calcipotriol and Betamethason, which is determined to give psoriasis scalp psoriasis. However, the experience of falling with this line is limited. Betriol fat used to treat psoriasis psoriasis on the skin can be combined with the gel form if there is a scalp psoriasis. mechanics.

    • Other: There is no clinical data on the use of drugs with psoriasis (Guttate compressed scales).

    The effect of drugs on driving ability, operating machinery

    does not have or less affect the ability to drive, operate machinery.

    used for pregnant and lactating women

    Pregnant women

    There is no adequate data in using preparations for pregnant women.

    Research on animals shows that corticosteroids have the potential to cause reproductive toxicity. However, epidemiological data does not record birth defects in newborns of women treated with corticosteroid during pregnancy.

    The potential risk is uncertain, so during pregnancy, the drug should only be used if the benefits are superior to the risk.

    breastfeeding women

    Be careful when taking topical corticosteroids for breastfeeding women. Betamethason is distributed into breast milk, but at the dose of treatment of toxicity on the baby is in the period of breastfeeding is uncertain.

    There is no data on Calcipotriol whether or not to go into breast milk or not.

    Be cautious when indicated for breastfeeding women

    Reproductive ability: Research on experimental mice at the dose of treatment, preparations combining calcificationriol and betamethasone does not reduce fertility.

    Drug interaction

    There is no study on interaction of other drugs with preparations containing Calcpotriol and Betamethason.

    Storage

    Leave a cool place, avoid light, temperature below 30⁰C.

    Other drugs

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