Bezina 10 Mediplantex medicine for preventive treatment migraine (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Flunarizin
Ingredient Mediplantex TW Joint Stock Company

Ingredient

Composition information	Content
Flunarizin	10mg

Uses

indications

Bezina 10 drug is indicated in the following cases:

Preventive treatment of migraine in case other treatments is not effective or less tolerant.

Pharmacological group: Calcium channel blockers.

flunarizin is an antihistamine, sedative, and calcium channel blockers. The drug prevents calcium overload in cells by reducing over -over -over -over calcium membrane. Flunarizin does not affect the heart muscle contraction, does not inhibit the atrial or atrial node, does not increase the heart frequency, does not have anti -hypertension effect.

Dynamic pharmacokinetics

absorption

Flunarizin absorbs well in the digestive tract, reaching the peak concentration in the gravity of the round 2 - 4 hours after drinking and reaching a stable state at the 5th - 6th week.

In the decreasing gastric acid (high concentration of gastric pH), the bioavailability of flunarizin may be lower.

distribution

Flunarizin binds plasma protein> 99%. Large distribution volume, about 78 liters/kg in healthy people and about 207 liters/kg in epilepsy patients shows high distribution capacity in the vasoma tissue. The drug quickly passed through the brain blood barrier, the concentration of the brain is about 10 times higher than the plasma concentration.

transformation

flunarizin is converted through the liver into at least 15 metabolites. The main metabolic line is CYP2D6.

Elimination

flunarizin excreted mainly through biliary feces in the form of original drugs and metabolites. Within 24 - 48 hours after drinking, about 3-5% of the dose is eliminated in the form of stool in the form of original drugs and metabolites, and 0.5 nanogam/ml) for a long time (up to 30 days), which may be due to the re -distribution of drugs from other tissues.

use the dose to repeat

Flunarizin's plasma concentrations achieve a stable state after about 8 weeks of reminded dose, once a day and about 3 times higher for single dose.

Before taking Bezina 10 Mediplantex medicine for preventive treatment migraine (6 blisters x 10 tablets)

How to use

oral tablets. Take the tablet with a glass of water.

Dosage

adults ≤ 65 years old and elderly> 65 years old:

Take 5 mg/day, take in the evening, maintain for 4 to 8 weeks. Should use other forms of preparation for more accurate dose.

During treatment, if the symptoms of depression, foreign tower or other serious disadvantages appear, it is necessary to stop taking the drug.

If after 8 weeks of treatment there is no improvement, the patient is considered not responded to treatment and should stop taking the drug.

Treatment time does not exceed 6 months.

Recommended for patients ≤ 65 years old: If the patient's clinical manifestation shows that the response is incomplete, may increase the dose up to 10 mg/day but need to consider in the patient's tolerance capacity.

Children ≥ 12 years: Especially in the case of unexplained migraine: Take 5 mg/day, take it in the evening. Treatment time does not exceed 6 months. Should use other forms of preparation for more accurate dose.

Children

Dosage in patients with liver failure: Because the drug is metabolized to a large level of the liver, the dosage should be adjusted in these patients. Starting dose: 5 mg/day, taken in the evening.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? A few cases of acute overdose (high dose to 600 mg oral 1 time) have been reported, symptoms observed as drowsiness, tachycardia, agitation.

Management: There is no specific antidote. Within 1 hour after overdose, the stomach should be lavely. Can use activated carbon if appropriate.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using Bezina 10 you may experience unwanted effects (ADR):

Summary of harmful reactions are grouped by frequency: Very common (ADR ≥ 1/10), common (1/100 ≤ ADR is common rarely dysplasia, tremor), depression worried digestive disorders delicious, weight gain dry mouth

rash

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Bezina 10 contraindicated drug in the following cases:

Sensitive people with flunarizin or any excipients of the drug.

People with Parkinson's symptoms before treatment.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Treatment with flunarizin may increase the symptoms of depression, foreign thap and the development of Parkinson's syndrome, especially for patients who are at risk as elderly. Caution should be used with these patients. Do not exceed the prescribed dose. Patients must be regularly examined, especially in the maintenance stage, to be able to detect foreign or depression symptoms early and stop treatment. If in maintenance treatment is not effective, then stop treatment. It is necessary to monitor patients regularly, periodically, especially during the maintenance treatment period to early detect expressions of extracurricular, depression and stop treatment promptly. If this condition occurs, it is necessary to stop treating with flunarizin. There is Celiac disease. If allergic to wheat (avoid confusion with Celiac disease), patients should not take this medication.

The effect of the drug on the ability to drive and operate machinery

Because the drug can cause drowsiness, especially at the beginning of treatment, it must be cautious in activities such as driving or operating machinery.

Use drugs for women during pregnancy and lactation

Pregnancy:

Caution when using.

There has been no study to confirm the safety of flunarizin when used in pregnant women. Therefore, it is not used in pregnant women, unless the benefits are superior to the risk of pregnancy.

breastfeeding period:

Caution when using.

It is unknown whether Flunarizin is distributed into human milk or not. Consider or avoid using drugs during breastfeeding or taking medicine and stopping breastfeeding.

Interactive drug

Simultaneous use of alcohol, sedative and sleeping pills with flunarizin increases the side effects of drowsiness. Flunarizin is not contraindicated in patients taking beta blockers.

Flunarizin's

pharmacokinetics are not affected by Topiramat. Topiramat's stable pharmacokinetic state is not affected by flunarizin.

Long -term use of flunarizin does not affect the plasma concentrations of phenytoin, carbamazepin, valproat or phenobarbital. Flunarizin's plasma concentrations are often lower than that of epilepsy patients who are using epilepsy drugs compared to healthy people using similar doses. Carbamazepine, Valproat and Phenyltoin's plasma proteins are not affected when using flunarizin simultaneously. Can increase sedative effects when used with alcohol, sleeping pills or antidepressants.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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