Bidacin 50mg Bidiphar medicine for hip or knee degeneration (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Diacerein
Ingredient Bidiphar

Ingredient

Composition information	Content
Diacerein	50mg

Uses

indications

Bidacin drugs indicated symptomatic treatment of osteoarthritis.

Pharmacology

The results of some studies in-vitro and in-vivo show that Diacerein and Rhein, a substance with its activity, inhibit the production and activity of Interuukin-1, inflammatory and pre-catabolic substance, both in the shallow and deep layer of cartilage, in the epidemic membrane and the epidemic, while stimulating the production of the TGF-Form. Ingredients of base cells such as proteoglycan, Aggrecan, hyaluronic acid and type II glue.

In addition, these substances also inhibit the macrophages and the movement of macrophages. Studies in some models of osteoarthritis in Diacerein animals reduce cartilage degeneration compared to untreated groups.

Clinical studies show significant pain relief and significant joint improvement compared to placebo (placo) after 1 month of treatment with diacerein. Other studies show that the beneficial effect of Diacerein treatment lasts at least 2 months after stopping treatment.

Dynamic pharmacokinetics

After oral use, diacerein passes through the liver and is reduced to acetyl into rhein. This substance is sulpho complex. After taking a single dose of 50 mg of diacerein, the peak concentration of plasma appears about 2.5 hours. Using diacerein at meals increases bioavailability. When using the dose of 50 mg to 200mg of diacerein in the form of single dose, all pharmacokinetics parameters do not depend on the dose. The combination with very high protein (99%). This is mainly due to strong affinity with albumin.

Rhein's semi -destructive time is about 4.5 hours. The total amount of drugs is eliminated in urine about 30%. About 80% Rhein is excreted in urine in the form of sulpho and glucuro combinations and about 20% in the form of rhein does not change. After using the dose repeated (50mg x 2 times /day), Diacerein shows a slight accumulation. In patients with severe renal impairment (creatinine clearance below 30 ml/minute), the area under the curve and the half -life of cancellation increased and eliminated through the urine by half.

Before taking Bidacin 50mg Bidiphar medicine for hip or knee degeneration (3 blisters x 10 tablets)

How to use

oral medication.

Dosage

Adults: Take 2 capsules a day, divided into 2 times, during meals.

For patients with renal insufficiency: Half of the dose in patients with creatinine clearance below 30 ml/min.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

If prolonged diarrhea requires symptoms and doctor's examination.

Emergency treatment includes intestinal wash and/or restoration of water - electrolytes, if necessary.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Common side effects when treating with diacerein is a rapid increase in food time through the intestines and abdominal pain. These symptoms may appear in the first few days of treatment and in most cases, these symptoms decrease on their own.

Diacerein can make dark yellow urine.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Bidacin drugs contraindicated in the following cases:

Patients with a history of hypersensitivity to diacerein and the ingredients of the drug.

Caution when using

should not prescribe diacerein for children under 15 years old because there is no clinical studies at this age group.

Do not use diacerein simultaneously with laxative drugs.

used for pregnant and lactating women

should not use diacerein for pregnant women. In addition, Diacerein should not be prescribed in women who are breastfeeding because there are reports showing small amounts of diacerein derivatives into breast milk.

The effect of drugs when driving and operating machinery

has not seen a report on the dangerous effect of diacerein on the ability to focus on driving or operating machinery and equipment.

Interactive drug

Interact with other drugs, other forms of interactions: avoid simultaneous use with salt, oxide or aluminum hydroxide, calcium and magnesium hydroxide because they reduce the absorption of diacerein. These substances can be used at another time (more than 2 hours) after taking Diacerein.

Storage

Avoid light and wet places, temperatures below 25ºC.

Other drugs

Disclaimer

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