Bidiferon medicine for preventive treatment iron and folic acid (10 blisters x 10 tablets)
Dosage form Film bag tablets
Specifications Box of 10 blisters x 10 tablets
Ingredient Folic Acid, Iron
Indication Iron anemia
Ingredient
Thành phần cho 1 viên
| Composition information | Content |
| Folic Acid | 0.35mg |
| Iron | 50mg |
Uses
Indications
Bidiferon 160.2 mg Bidiphar 10x10 is indicated for iron deficiency and folic acid prophylaxis during pregnancy when food does not provide sufficient amounts. It is not used in preventing abnormal risks of embryo neural tube. Bidiferon can be used in pregnant women.
Pharmacokology
Pharmacological group: Vitamins and minerals.
Code ATC: B03AD03
Pharmacological and mechanism of action:
related to iron
Mechanism of action: iron is the central atom of heme, constituent hemoglobin and is also essential for red blood cell creation.
Pharmacological effects: iron is distinguished from other minerals: Due to the absence of physiological excretion mechanism, the equilibrium state of iron in the human body is regulated by iron absorption. The absorption of sulfate iron (FeSO) is carried out by iron transportation (DMT) at the tip of the small intestine (duodenum and near the rosary).
related to folic acid
Mechanism of action: Folic acid (folat) acts as a coenzyme in transporting carbon atoms from the biosynthesis of nucleotides purine and Devothymidic acids needed for DNA and RNA synthesis. In general, the growth and multiplication of cells requires high amounts of folic acid: like the tissues of the nervous system and red blood cells.
Pharmacological effects: The human body cannot synthesize folic acid, so the amount of folic acid input is mainly from the diet. Folic acid has the ability to absorb faster in the intestine because of higher than natural folat.
Safety and clinical effectiveness: A single, random clinical test with 131 pregnant women has been conducted to assess the effects of iron and folic acid on pregnant women's biological indicators. This study showed that the addition of iron and folic acid limits the decline in biological criteria of plasma plasma hemoglobin and plasma ferritin) and folic acid (folat red blood cells and serum folat) at birth.
pharmacokinetic pharmacokinetics
related to iron
absorption
iron absorption is a process that is mainly located in the duodenum and near the rosary. The combination of iron sulfate and excipients allows continuous release of iron. Increased absorption when iron reserves decreased.
iron absorption may be changed by simultaneous use of certain foods, drinks or sharing some drugs (see warning and caution and interaction, cavalry of the drug).
Distribution
In the body, iron reserves are mainly found in the bone marrow (pink blood cells), red blood cells, liver and spleen. In the blood, iron is transported mainly by transferin to the bone marrow, where it is combined into hemoglobin.
Metabolism
iron is a metal ion, not metabolized through the liver.
Elimination
The main excretion of the gastrointestinal tract (peeling of the intestinal cell, the recession of heme leads to the drainage of red blood cells), the urinary tract and the skin.
related to folic acid
absorption
Folic acid (folat) is quickly absorbed into the digestive tract, mainly at the tip of the small intestine.
Distribution
Folat is distributed throughout the body. The main storage place of folat is the liver. They also focus on cerebrospinal fluid. Folat is also excreted in breast milk.
Metabolism
Folat is transformed into an active metabolic form: 5-methyllahydrofolate (5MTHF) in plasma and liver. Folat metabolites enter the liver - intestinal cycle.
Elimination
Folat metabolites are eliminated in urine and redundant folats excreted in the form of constant urine.
Before taking Bidiferon medicine for preventive treatment iron and folic acid (10 blisters x 10 tablets)
How to use
Bidiferon 160.2 mg orally. Drink whole tablets with lots of water. Do not chew or suck in the mouth. It is best to drink before meals, but can be adjusted according to the gastrointestinal tolerance.
Dosage
One tablet per day (equivalent to 50 mg of elemental iron and 0.35 mg of folic acid) in the last 2 months of pregnancy (or from the 4th month of pregnancy).
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.
What to do when overdose?
Overdose
Cases of overdose of iron salt have been recorded, especially in children due to accidentally swallowed. Symptoms include irritation and gastrointestinal necrosis that leads to abdominal pain, half vomiting, bleeding diarrhea, acute renal failure, liver failure, and convulsions.
How to handle overdose drugs
It is necessary to treat as soon as possible, carry out the stomach with 1%sodium bicarbonate solution.
Depending on the serum iron concentration, the use of chelate may be recommended, especially when using Deferoxamin. If necessary, please refer to Deferoxamin's product information.
In an emergency, call the 115 emergency center immediately or go to the nearest local health station.
What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.
Side Effects
When using Bidiferon 160.2 mg Bidiphar 10x10, you may experience unwanted effects (ADR).
related to iron
Common, 1/100 Rare, 1/1000 Gastrointestinal disorders: abnormal stools, indigestion, vomiting, gastritis. Unknown (not evaluated from existing data) Skin and tissue disorders: itching, rash. (*) In the case of chewing or sucking tablets in the mouth. From post -commercial data, the following side effects have been reported with unknown frequency. Hypersensitivity, urticaria, dental disorders *, mouth ulcers * and gastrointestinal melanoma have been reported with unknown frequencies (see above). Patients with elderly people and patients with disorders may be prone to esophageal or bronchial necrosis in the case of swallowing the wrong way. Other special cases According to existing data, the pigmentation of the gastrointestinal mucosa (post -death hemoglobin/melanoma) has been observed in patients with iron supplements. This pigment can interfere with stomach -intestinal surgery (see warning and caution). related to folic acid unknown (not evaluated from existing data) Gastrointestinal disorders: digestive disorders. Skin and subcutaneous tissue disorders: edema, atopic dermatitis, urticaria. Instructions on how to handle ADR Can limit the ADR often by taking low doses, then increasing, or taking a little food (thus reducing iron absorption). When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
Contraindicated
Bidiferon 160.2 mg Bidiphar 10x10 contraindications in the following cases:
Persistent anemia.
Precautions when using
Plasma iron deficiency is associated with inflammatory syndrome that are not sensitive to iron supplements.
Must combine iron supplements with cause treatment.
Due to the risk of dyeing teeth and mouth ulcers, avoid chewing or sucking in the mouth. Must swallow the whole tablet with many countries.
According to the existing document, the pigmentation of the stomach - intestinal mucosa (post -death hemoglobin/melanoma) has been observed in patients with iron supplements.This pigment can interfere with stomach -intestinal surgery and therefore should be noted, especially in scheduled surgery. Therefore, it is necessary to notify the surgeon about the current iron supplementation along with this risk (see the unwanted effect section).
Drinking plenty of tea reduces iron absorption.
The ability to drive and operate machinery
The drug does not affect the ability to drive and operate the machine.
Pregnancy
Clinical data on several thousand women treated does not show the adverse effects of sulfate iron. Therefore, under normal conditions, this drug can be used during pregnancy.
Animal studies show that there is no impact on the fertility of both men and women.
Breastfeeding period
The excretion of sulfate iron into milk has not been evaluated, but based on molecular structure, preparations can be used for breastfeeding women.
Drug interaction
related to iron
Coordination should not be used
iron (salt) (oral): causes fainting, even shocked by the rapid release of iron from the complex form and by Siderophilin saturation.
Coordination should be considered
acetohydroxamic acid: Reduce the absorption of the gastrointestinal tract of these two drugs due to iron chelate.
Cautious coordination when using
biphosphonate (oral): reduces the absorption of diphosphonate. Use these drugs from at least 30 minutes to more than 2 hours if possible.
calcium: Reduce the absorption of the digestive tract of iron salt. Use iron salt away from meals and without calcium.
Cyclin (oral): Reduce the absorption of cyclin due to forming a complex. Use these drugs at least 2 hours apart.
Entecapon: Reducing the absorption of Entecapon and iron due to the chelate of Entacapon. Use these drugs at least 2 hours apart.
fluoroquinolon: iron reduces the absorption of fluoroquinolon. Using these drugs should be at least 2 hours apart.
thyroid hormone: reduces the absorption of thyroid hormone. Use these drugs at least 2 hours apart.
Levodopa/Carbidopa: Reduce the absorption of Levodopa/Carbidopa. Use these drugs at least 2 hours apart.
methyldopa: Reducing methyldopa absorption due to a complex formation. Use these drugs at least 2 hours apart.
penicilamin: reduces the absorption of penicilamin. Use these drugs at least 2 hours apart.
Strontium: Reducing the absorption of Strontium. Use these drugs at least 2 hours apart.
Zinc: Reduce the absorption of zinc. Use these drugs at least 2 hours apart.
Salt, oxyd, hydroxyd of Mg, Al, Ca (covering the stomach lining): Reducing the absorption of the digestive tract of iron salts. Use these drugs 2 hours apart.
cholestyramin: Reduce iron absorption. Use iron before using cholestyramin 1 - 2 hours or after using Cholestyramin 4 hours.
Other types of interactions: Phytic acid (whole grain), beans, polyphenols (tea, coffee, red wine), calcium (milk, dairy products) and some proteins (eggs) significantly inhibit the absorption of iron. Use iron away from these foods at least 2 hours.
related to folic acid
Phenobarbital, primidon, phenytoin, fosphenytoin: Reduce plasma concentrations of anti -convulsions by increasing liver specialization, in which folic acid is thought to be one of the co -factors. Clinically monitor, control the concentration of anti -convulsions in plasma and, when appropriate, adjust the anti -epileptic dose while supplementing and after folic stops.
Cavalry of the drug: has not found the drug's information.
Storage
In a dry place, the temperature does not exceed 30 ° C, avoiding light.
Expiry date: 36 months from the date of production.
Do not use overdue drugs indicated on the packaging.
Manufacturer: Pharmaceutical Joint Stock Company - TTBYT Binh Dinh (Bidiphar).
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