Bifehema Bidiphar solution for iron deficiency anemia (20 tubes x 10ml)

Dosage form Syrup
Specifications 20 tube box
Ingredient Gluconate, manganese gluconate, iron gluconate
Indication Pregnancy, iron deficiency anemia
Contraindication Inflammation, drug allergy

Ingredient

Composition information	Content
Gluconate	0.7mg
Manganese Gluconate	1.33mg
Iron gluconate	50mg

Uses

indications

Bifehema is indicated in the following cases:

The treatment of iron deficiency anemia.

Support the treatment of anemia, mineral supplements and trace elements.

ATC code: b03aej0

Pharmacology and action mechanism

iron is essential for the body to synthesize heme, part of hemoglobin, myoglobin and other metal-protein in the body. Iron participates in oxidation - reduction process.

Iron deficiency is the main cause of anemia due to human nutrition. Causes of iron deficiency may be due to iron -deficient food, due to poor absorption, blood loss or increased demand during pregnancy, growing children.

Copper and manganese are important components of many enamel systems in the body, and also participate in oxidation - reduction. Lack of copper can affect the absorption of iron and the release of iron from the endothelium.

Manganese is an essential element for bones, skin, ligaments, functions of insulin, and also the active agent of some enzymes. Manganese is essential for normal development process, plays a role in cholesterol synthesis and sperm production.

pharmacokinetics

iron

iron salt is less absorbed when orally (10% to 20% of oral oral). The absorption level increases when the amount of iron reserves is reduced. The absorption place is mainly in the duodenum and the rosaries. The mechanism of iron penetrates the mucosa of the gastrointestinal tract is unknown.

Dong

approximately 50% of the amount of copper is absorbed in the stomach. The copper is completely transformed in the blood by attaching to albumin, followed by a special protein of copper (ceruloplasmin). Copper is accumulated in the liver and bone marrow as metallothonein. Normally, the copper is out of the secret, where it plays an important role in the communication of the field.

Manganese

is absorbed from the small intestine and is transferred to the blood, attached to a β1 -myGlobulin, Transmanganin. The manganese is excreted through the bile and through the intestinal wall, this element is also excluded in the pancreatic activity. A very small amount of cards exported through urine.

Before taking Bifehema Bidiphar solution for iron deficiency anemia (20 tubes x 10ml)

How to use

dilute the medicine tube in water or alcohol -free water (children can mix with sugar water).

Take before meals, but can adjust the time and dose accordingly.

Dosage

Treatment

Adults: 100 - 200 mg of iron/day (2 - 4 tubes/day), divided into several times a day.

Children over 1 month of age: 5 - 10 mg iron/kg/day.

Backup

Pregnant women: 50 mg of iron/day (1 tube/day) in the next two quarters of pregnancy (or starting from the fourth month of pregnancy).

Treatment time

The treatment time must be sufficient to adjust anemia and restore iron reserves (in adults: 600 mg for women and 1200 mg for men).

iron deficiency anemia: 3 - 6 months depending on the amount of reserve decline, maybe longer if the cause of anemia is not controlled.

Just check the effectiveness after at least 3 months of treatment: it must be related to the overcoming anemia (HB, VGM) and restoring the amount of iron reserves.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? Symptoms include irritation and stomach necrosis, most cases are accompanied by vomiting, vomiting and shock.

It is necessary to treat as soon as possible, carry out the stomach with 1%sodium bicarbonate solution.

Using chelat complex substances is very effective, especially when using Deferoxamine, mainly when the iron concentration in the blood is over 5 PG/ml. Shocking, dehydration and acid - base abnormalities are treated with classical methods.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use double the prescribed dose.

Side Effects

Unknown frequency

Gastrointestinal disorders: Nausea, stomach burning, constipation or diarrhea, dyeing black teeth, black stools (no effect).

Immune system disorders: Allergic reactions.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

contraindicated

Bifehema drugs contraindicent in the following cases:

Hypersensitivity to the active ingredients or any ingredients of the drug.

Iron overload in normal anemia or iron canopy anemia such as Thalassemia, persistent anemia, myeloma and inflammatory anemia.

Caution when using

Preventing deficiency in infants based on giving a diverse diet.

This drug is not recommended in the treatment of serum iron deficiency in inflammatory syndrome.

Must combine iron supplements with cause treatment. The drug contains sucrose, cautious in the case of patients with diabetes. It is not recommended to use in patients with fructose intolerance, glucose and galactose or sucrase/isomaltase deficiency.

The drug contains glucose, cautious in the case of a patient with diabetes. Unable to encourage the use in patients with glucose and galactose absorption disorders.

The presence of glucose and sucrose can be harmful to teeth in case of prolonged use (at least 2 weeks).

The drug contains sorbitol, not recommended for use in case the patient does not intolerize fructose.

ASPARTAM -containing drugs: Be cautious in patients with phenylceton.

Drinking plenty of tea will reduce iron absorption.

To prevent black dyed teeth (will go away on its own), do not take a long time in the mouth.

The ability to drive and operate machinery

no document proves that the drug has an impact on the driver or operating the machine.

Pregnancy

data available on some pregnant women does not show any special risk for pregnant women or fetuses or infants. Therefore, under normal use conditions, this drug can be prescribed for pregnant women.

The period of breastfeeding

The excretion of the drug in milk has not been evaluated, so the use of drugs in breastfeeding women is only considered if necessary.

Drug interaction

should not coordinate

iron preparations (salt; injection): faint, even shocked by rapid release of iron from complex form and by saturated siderophilin.

Precautions when coordinating

Cyclin (oral): Reduce the absorption of cyclin due to forming a complex. Use these drugs at least 2 hours apart.

fluoroquinolon: iron reduces the absorption of fluoroquinolon. Using these drugs should be 2 hours apart.

Salt, oxyd, hydroxyd Mg, Al, Ca (covering the stomach - intestinal mucosa): Reducing the absorption of the digestive tract of iron salt. Use these drugs 2 hours apart.

diphosphonate (oral): reduces the absorption of diphosphonate. Use these drugs at least 2 hours apart.

penicilamin: reduces the absorption of penicilamin. Use these drugs at least 2 hours apart.

thyroxin (oral): reduces the absorption of thyroxin. Use these drugs at least 2 hours apart.

Food: Use lots of teas reduces iron absorption. Use iron salt with tea apart.

Storage

Store in a dry place, the temperature does not exceed 30 ° C, avoiding light.

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