BilClamos Bid 1000mg Bilim Ilac Treatment of infection (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Amoxicillin, clavulanic acid
Ingredient Bilim

Ingredient

Composition information	Content
Amoxicillin	875mg
Clavulanic Acid	125mg

Uses

Indications

bilclamos 1000 mg is used to treat the following cases of infection:

Heavy respiratory infections: tonsillitis, sinusitis, otitis media have been treated with conventional antibiotics but does not help.

Lower respiratory infections by H. Influenzae and Branhamella CatVrhalis produce beta - Lactamase: Acute and chronic bronchitis, pneumonia - bronchial.

Severe - genital infections by E.coli strains, Klebsiella spp., and Entobacter spp. Production of beta - lactamase: cystitis, urethritis, pyelonephritis (female genital tract infection).

Skin infections and soft tissue: pimples, abscesses, wound infections.

Bone and joint infections: Bone inflammation.

Dental infections: tooth abscess.

Pharmacy

Amoxicillin is a semi -synthetic antibiotic belonging to the Beta - Lactam family with wide bactericidal spectrum for many Gram -positive and gram -negative bacteria due to synthetic inhibition of bacterial cell walls.

But because Amoxicillin is easily destroyed by beta - lactamase, therefore does not work for bacterial strains producing these enzymes (many of En

Clavulanic acid due to the fermentation of StreptoneyCes Clavuligerus, which has a beta - lactam structure similar to penicillin, has the ability to inhibit beta - lactamase due to the majority of Gram -negative bacteria and Staphylococcus. Especially, it has a strong inhibition effect of beta - lactamase transmitted via plasimids that resist penicillin and cephalosporins. Pseudomonas Aeruginosa, Proteus Organi and P. Religeri, some entobacter strains and providentia anti -drugs, and methicillin resistant staphylococcus are also resistant to this drug. Clavulanic acid itself has very weak antibacterial effects.

Bilclamos 1000 mg film tablets are a combination of amoxicillin and clavulanic acid in the same preparation. Clavulanic acid helps Amoxicillin not be destroyed by beta - lactamase, while expanding the antibacterial spectrum of amoxicillin effectively to many common bacteria that have resisted amoxicillin, resistant penicillins and other cephalosporins. Amoxicillin and clavulanic acid can be considered to be an antibacterial poison for pneumoccus, streptococcus beta beta, staphylococcus (penicillin -sensitive strains are not affected by penicillinase), Haemophilus influenzae and Branhamella Catatrhalis including strong products of strong Beta - Beta - lactamase.

In summary, the antibacterial spectrum of the drug includes:

Gram -positive bacteria:

Aerobic type: Streptococcus Faecalis, Streptococcus Pneumoniae, Streptococcus Pyogenes, Streptococcus Viridans, Staphylococcus aureus, Corynebacterium, Bacillus anthracis, Listeria monocytogenes. Clostridium, peptococcus, peptostreptoccus.

Gram -negative bacteria:

Aerobic type: Haemophilus Influenzae, Escherichia Coli, Prenseu Smirabilis, Proteus vulgaris, Klebsiella, Salmonella, Shigella, Bordetella, Neisseria Gonorrhoeae, Neisseria Meningitidis, Vibrio Cholerae, PasteLae, Pasteella Multocida. The concentration of these two substances in the serum is up to 1-2 hours of taking the drug, with the dose of BilClamos BID 1000 mg will have 8-9 micrograms/mloxicillin and about 3 micrograms/ml of clavulanic acid in serum. The absorption of the drug is not affected by food and it is best to drink right before meals.

Distribution: About 20% of drugs are linked to plasma proteins after the common circulation. The drug is widely distributed at different concentrations in tissues and fluids in the body: middle ear fluid, abdominal fluid, pleural fluid, urine, intestinal mucosa, bile ... The drug through the placenta, and a small part of the drug can be added to breast milk. The drug is very little into the cerebrospinal fluid, unless the meninges are inflamed. The oral bioavailability of amoxicillin is 90% and of Clavulanic acid is 75%.

Metabolism: After entering the body, a part of amoxicillin is converted into a corresponding penicilloic acid. About 20% of oral dose is found in urine in this form.

Elimination: The half -life of amoxicillin in serum is 1-2 hours and of clavulanic acid is about 1 hour. About 55 - 70% amoxicillin and 30-40% Clavulanic acid are discharged in urine in the form of activity. Probenecid extends Amoxicillin's elimination time but does not affect the elimination of clavulanic acid.

Before taking BilClamos Bid 1000mg Bilim Ilac Treatment of infection (2 blisters x 7 tablets)

How to use

Take tablets, no chewing, or crushing tablets.

Dosage

for adults and children over 12 years old.

If there is no other special instructions, use BilClamos BID 1000 mg 1 tablet/time 2 times a day, in adults.

Use drugs in patients with renal failure: Do not use Bilclamos BID 1000 mg in patients with low clearance (

Use drugs in patients with liver failure: closely monitor liver function in patients with liver failure.

Use children's drugs

Children from 40kg or more, drink adult dose.

Children under 40kg of weight:

The usual dose: 20 mg/kg amoxicillin, divided into several times 8 hours apart.

What to do when overdose? In case the renal function decreases and the blood -brain barrier, the drug may cause symptoms of poisoning. However, general reactions occur depending on the hypersensitivity of each individual. The risk is definitely hyperkalemia when taking a very high dose because clavulanic acid is used in the form of potassium salt. Can use the method of hemolysis so that the drug is circulating.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using BilClamos BID 1000 mg, you may experience unwanted effects (ADR).

With normal doses, unwanted effects show over 5% of patients.

The most common are digestive reactions: diarrhea, nausea, vomiting.

Common side effects, ADR> 1/10)

Digestive: diarrhea.

Skin: Outdoor, itching.

Side effects are less common, 1/1000

Blood: Nothing hypernagus.

digestion: Nausea, vomiting. liver: hepatitis and jaundice, increased transaminase. Can be heavy and last for a few months. Skin: itching, erythema, rash.

Rare side effects, ADR

Systemic: Anaphylaxis reactions, edema Quincke.

Blood: A mitigation of platelets, leukopenia, hemolytic anemia. digestive: Fake colitis. skin: Stevens - Johnson syndrome, polymorphic erythema, peeling dermatitis, epidermal necrosis due to poisoning. kidney: interstitial nephritis.

Instructions on how to handle ADR

When there is a serious anaphylactic reaction, it should be treated immediately by adrenalin, oxygen, intravenous corticosteroids, ventilation.

Increase Viira Transaminase: Clinical significance is not well known. Need to monitor to prevent the detection of cholestatic hepatitis.

Radio, erythema, Stevens syndrome - Johnson, Bong dermatitis: Must stop the drug.

fake colitis:

If mild: stop the drug.

If heavy (the ability by Clostridium Difficile): Water and electrolyte, anti -Clostridium antibiotic.

Notice immediately to the doctor or pharmacist when encountering unwanted effects of the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Bilclamos drugs contraindicated in the following cases:

allergies to beta - lactam antibiotics (penicillin, and cephalosporin). penicillin because clavulanic acid causes increased risk of cholestasis in the liver.

Prisable when using

For patients with manifestation of liver dysfunction: Signs and symptoms of cholestasis jaundice occur rarely when taking the drug but may be severe. However, these symptoms are often recovered and will end after 6 weeks of stopping treatment.

For people with average or severe renal impairment, attention should be paid to the dosage.

For patients with a history of hypersensitivity to penicillin may have severe reactions or death.

For those who use amoxicillin with redness with lymphadenopathy. Prolonged medication sometimes develops anti -drug bacteria.

The ability to drive and operate machinery

has not detected any effect of the drug on the ability to drive and operate machinery.

Pregnancy

Experimental research on the reproductive process of mice proved when using non -deformed preparations. However, because there is little experience in using preparations for pregnant women, it is necessary to avoid using drugs in pregnant women, especially in the first 3 months, except for the necessary cases prescribed by a physician.

Breastfeeding period

Women during breastfeeding can use preparations. The drug is not harmful to breastfeeding unless there is a risk of sensitivity due to a very small amount of medicine.

Medicinal interaction

The drug can cause prolonged bleeding time and blood clotting. Therefore, it is necessary to be careful for those who are treated with anticoagulants.

Like antibiotics with broad effects, the drug can reduce the effectiveness of oral contraceptives, so it is necessary to notice to the patient in advance.

Storage

Store in closed packaging, at temperatures below 30 ° C.

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