Biresort 10 Bidiphar prevents and treats angina, congestive heart failure (3 blisters x 20 tablets)

Dosage form Box of 3 blisters x 20 tablets
Specifications Isosorbid Dinitrat
Ingredient Heart failure, angina

Ingredient

Composition information	Content
Isosorbid Dinitrat	10mg

Uses

indications

Biresort drugs are indicated in the following cases:

Prevent and treat angina. The pressure in the heart chamber.

Nitrate also has the effect of inhibiting platelet gathering.

In the failure, reducing the burden, reducing the burden will reduce the attack and oxygen consumption of the heart muscle, supply and demand for the balanced heart muscle will quickly cut angina.

Dynamic pharmacokinetics

absorption: Isosorbid Dinitrate (ISDN) used in oral form will be absorbed faster when sucking under the tongue or chewing. The effect of the drug depends on the use: suck under the tongue (starting to work after 2 minutes, the maximum effect after 15 - 45 minutes, lasting 1-3 hours). Chewing (starting to work after 5 - 20 minutes, lasting 1-3 hours). Drink (starting to work after 15 - 45 minutes, maximum effect after 45 - 120 minutes, lasting 2 - 6 hours).

Distribution: Drugs combined with plasma protein up to 28 ± 12%.

Metabolism: The drug is metabolized much when passing the liver for the first time. The two main metabolites are active: Isosorbid - 2 Mononitrate (2 - ISMN) has a short time and isosorbid - 5 Mononitrate (5 - ISMN) has a longer -effect time.

Elimination: The main excretion of urine, half -life excreted by plasma of ISDN is 50 ± 20 minutes, of 2 - ISMN about 2 hours, of 5 - ISMN about 5 hours.

Before taking Biresort 10 Bidiphar prevents and treats angina, congestive heart failure (3 blisters x 20 tablets)

How to use

suck under the tongue or chew or drink.

Dosage

Treatment of angina: suck under the tongue or chew 2.5 - 10 mg/time, every 2-3 hours until the end of the pain.

Prevention of angina: Take 10- 20 mg/time x 3-4 times/day.

Treatment of congestive heart failure: suck under the tongue or chew 5 - 10 mg or take 10 - 20 mg/time or more than x 3-4 times/day, then reduce the maintenance dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Gastric lavage immediately if used by oral medication.

What to do when forgetting 1 dose? If you forget to take a dose, take a dose right after remembering and take the next dose at the right time.

Side Effects

When using Biresort 10, you may experience unwanted effects (ADR).

Very common, ADR> 1/10

TKTW: headache.

Cardiovascular: Peripheral vasodilation makes the skin flushed.

Common, ADR> 1/100

Cardiovascular: Reducing blood pressure and/or hypoglycemia with tachycardia and symptoms of reflection/signs of ischemia (drowsiness, dizziness and weak health) during the first use and when increasing the dose.

Peripheral edema in patients treat left ventricular failure.

Uncommon, 1/1000

Digestive: Nausea and vomiting

Dermatology: skin allergic reaction

Cardiovascular: Reducing blood pressure with increased symptoms of angina, association with slow heart rate and arrhythmia

Very rare, ADR

Skin exterior: Peeling dermatitis/Steven Johnsons syndrome or angioedema.

Respiratory: reducing alveolar ventilation with the result of blood oxygen deficiency and the risk of myocardial infarction in patients with coronary heart disease.

Eyes: Narrow angle glaucoma.

Pituitary gland: Pituitary hemorrhage in patients with pituitary tumors is not diagnosed.

Other: Increased tolerance and diagonal tolerance against other nitrates have been recorded. Increasing doses and/or changes in doses can lead to decreasing or even drug loss.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Biresort 10 contraindications in the following cases:

Hypersensitivity to isosorbid Dinitrate or mononitrate or any ingredient of the drug.

Acute circulation (shock, vascular collapse).

Angina due to congested myocardial hypertrophy.

Very low blood pressure or low filling pressure (Isosorbid Dinitrate avoids use for patients with hemorrhage or patients with blood volume loss).

severe anemia, heart -pressed, aortic stenosis, ventricular exterior inflammation, mitral stenosis.

Right myocardial infarction.

Increased intracranial pressure.

Patients with pneumonia.

Combination of inhibitor 5 - Phosphodiester (eg Sildenafil, Tadalafil, Vardenafil with Biresort 10 tablets.

Be cautious when using

When taking the drug, the drug must be increased slowly to avoid the risk of lowering hypotension and headache in some patients, sitting or lying after taking the drug.

When using high doses should not reduce the drug suddenly.

Be cautious when taking medicine for the elderly, especially people who are sensitive to drugs that cause hypotension.

Safety and effectiveness of drugs with children has not been determined.

The ability to drive and operate machinery

should be cautious because the drug can cause dizziness, headache, dizziness, especially in the beginning of treatment.

Pregnancy

There has been no report on the effects of drugs on pregnant women.

Breastfeeding period

It is unknown whether the drug is excreted in milk or not, no background using isosorbid Dinitrate for nursing women.

Interactive drugs

Using alcohol will increase vascular dilatation and hypotension seriously.

Use drugs along with Disopyramid's anti -secretion effect anti -blood secretion that hinder the solubility of ISOSorbid Dinitrate suck.

Inhibitors 5 - Phosphodiester (eg Sildenafil, Tadalafil, Vardenafil) increase the effectiveness of nitrate hypotension due to additional vascular dilatation, causing serious hypotension, there have been deaths.

Storage

Store in a closed place, avoid light, temperature not exceeding 300C.

Other drugs

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