Bisnol Davipharm medicine for ulcerative stomach, duodenum (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Bismuth oxyd
Ingredient Peptic ulcer

Ingredient

Composition information	Content
Bismuth oxyd	120mg

Uses

indications

Bisnol drugs are indicated in the following cases:

Treatment of stomach and duodenal ulcer.

Often used with other drugs, especially metronidazol with tetracyclin or amoxicilin (therapy regimen) to kill all Helicobacter pylori and thus prevent duodenal ulcer. Stomach ulcers, and normal stomach mucosa does not have this effect. After drinking, the precipitate contains bismuth formed by the effects of gastric acid on Bismuth. In ulcers (both in the stomach and duodenum), many protein products are released continuously in relatively large amounts due to tissue necrosis.

Through the formation of a chelat complex, these flavored products, along with the precipitate, are obtained from bismuth, creating a protective layer that is not affected by gastric juice or enzymes in the intestine. This barrier can also prevent the effects of pepsin on ulcerative site.

bismuth has a bactericidal effect Helicobacter pylori. The minimum inhibitory concentration (mic) in vitro changes in the range of 5 - 25 micrograms/ml.

Bismuth is also used in combination with proton pump inhibitors or h2 huistamine and antibiotic receptors to kill Helicobacter pylori. When used for monomers, bismuth compounds only kill Helicobacter pylori at about 20% of patients. However, when combined with antibiotics and proton pump inhibitors, up to 95% of patients are eliminated H. Pylori.

Dynamic pharmacokinetics

tripotassium dicitrato bismuthate are absorbed very slowly and varies a lot depending on individuals. After taking Tripotassium Dicitrato Bismuthate, most bismuths see in the feces. However, a small amount of absorbed will be out of the urine. Bismuth's validity depends on the effect of the ulcerative site. With the recommended dose, the absorption is less so it can be toxic.

Before taking Bisnol Davipharm medicine for ulcerative stomach, duodenum (6 blisters x 10 tablets)

How to use

oral medication.

Dosage

Adults and the elderly

One tablet used 4 times/day, half an hour before 3 main meals and 2 hours after the last meal of the day; or 2 capsules 2 times/day, half an hour before breakfast and half an hour before dinner.

The maximum treatment time of a procedure is 2 months; Do not use tripotassium dicitrato bismuthate maintenance.

Children

Do not recommend using drugs for children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? However, there has been a notice of renal failure, brain disease and neurotoxicity after acute or chronic overdose. Bismuth has been detected in the blood, urine, stool and kidneys of these patients; Blood concentration of 1.6 micrograms/ml was seen 4 hours after taking a dose of 9.6 g.

Take for a long -term treatment, over 2 years away, notified to cause paresthesia, insomnia and memory loss. With the recommended doses of bismuth, there is no brain disease, but if the bismuth concentration in the blood exceeds 10 nanogam/ml, it is necessary to stop bismuth preparations.

Optimal treatment for overdose Bismuth is currently unknown. Stomach, bleaching and rehydration should be slow, even when the patient comes slowly, because Bismuth can be absorbed in the colon. Chelate agents can be effective at the early stage after oral and 2.3-Dimercapto-1-Propan Sulfonic at a dose of 100 mg, 3 times/day, increasing the clearing of bismuth in the kidneys and reducing blood levels. Bloody mitosis may need but accelerating the removal of drugs in tissue or not knowing for sure.

What to do when forgetting 1 dose? If you forget to take a dose, use that dose before the next meal, as long as this does not lead to double the bureaucracy. If in that case, skip the forgotten dose.

Side Effects

When using Bisnol, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: black dyeing.

Uncommon, 1/1,000

Digestive: Nausea, vomiting, constipation, diarrhea.

Skin and subcutaneous tissue: rash, itching.

Very rare, ADR

Body: Anaphylaxis.

Instructions on how to handle ADR

When experiencing the side effects of the drug, the doctor should notify the doctor.

Warnings

Contraindicated

Bisnol drugs contraindicated in the following cases:

Too hypersensitivity to Tripotassium Dicitrato Bismuthate or any ingredient of the drug.

Patients with low potassium diet.

People with severe kidney disease, due to the ability to accumulate bismuth accompanied by the risk of toxicity.

Be cautious when used

previous bismuth compounds are announced that can cause brain disease. The recommended dose (480 mg/day) is much lower than the dose that can cause brain disease. However, the risk of bismuth poisoning may increase if the recommended dose exceeds the level of overdose, poisoning, taking medicine for a long time or taking it with other compounds containing Bismuth. Therefore, it is not recommended to use long -term (oral) therapy with bismuth.

Be cautious when using bismuth for patients with a history of gastrointestinal bleeding (because bismuth causes black stools that can be confused with black bloody).

The drug contains about 2 mmol (about 40 mg) of potassium/tablet. It is important to consider when using the drug in patients with impaired renal function or patients who are in potassium -controlled diet.

The drug contains lactose, patients with rare genetic diseases galactose, Lapp Lactase deficiency or glucose - galactose absorption disorders should not use this drug.

Drugs that contain polysorbat 80 can cause allergies and castor oils that can cause nausea, vomiting, abdominal pain, diarrhea.

The ability to drive and operate machinery

No report.

Pregnancy

No long -term studies have been conducted to assess the potential of bismuth about cancer, causing mutations or harmful to fertility. Do not recommend using bismuth during pregnancy.

Lactating period

bismuth in the milk, but it is not clear whether or not to be harmful to babies. Therefore, it is not recommended to use this medication for breastfeeding mother unless the expected benefits are outstanding potential risks.

Drug interaction

Pre -treatment with omeprazol increases bismuth absorption to 3 times, suggesting an increased risk of toxicity if using these 2 drugs.

Concentrated with H2 or antacid antagonists reduces the effectiveness of bismuth salts compared to when used alone in ulcerative disease.

Bismuth absorbs X -rays, can hinder the diagnosis of the digestive tract by X -rays. Do not use other drugs, food or drinks, especially antacids, milk, fruits or juice for 30 minutes before or after tripotassium dicitrato bismuthate because the effectiveness of the drug can be affected. The effectiveness of tetracyclin orally can be inhibited.

Storage

Keep the drug in the original packaging of the manufacturer, covered.

Leave the drug in a dry place, avoid light, the temperature does not exceed 30 ° C, and out of the reach of children. Do not use the drug after the expiry date stated on the packaging (box and blister).

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