Bisolvon 8mg Boehringer is thin sputum, mucus (3 blisters x 10 tablets)

Dosage form Tablet
Specifications Box of 3 blisters x 10 tablets
Ingredient Bromhexine
Indication Acute bronchitis, bronchiectasis, chronic obstructive pulmonary, chronic respiratory failure, ATBET pulmonary (asbestos), chronic bronchitis
Contraindication Acute renal failure, chronic renal failure, liver failure, peptic ulcer, bronchial asthma

Ingredient

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Composition information	Content
Bromhexine	8mg

Uses

Indications

8mg Bisolvon drugs are indicated to dilute phlegm in acute and chronic bronchial diseases accompanied by abnormal mucus secretion and reduce the transport of mucus.

Pharmacokological

Bromhexine is a synthetic derivative from the active ingredient of Vasicine herbal ingredient.

Clinical, bromhexine is noticed that increases the ratio of bronchodilatoma. Bromhexine increases the transportation of mucus by reducing the mucus and active epithelium with velvet (purifying the mucus of velvet).

In clinical trials, bromhexine shows the effect of decomposing secretions and transporting secretions in the bronchial sugar to help facilitate sputum and cough.

After treatment with bromhexine, antibiotic concentration (amoxicillin, erythromycin, oxytetracyclin) in phlegm and bronchial secretions increase.

pharmacokinetic

absorption:

Bromhexine is absorbed quickly and completely through the digestive tract.

Birth is equivalent after taking solid form and solution.

Absolute bioavailability of Bromhexine Hydrochloride is about 22.2 ± 8.5% and 26.8 ± 13.1% corresponding to Bisolvon tablets and solutions.

The first amount of specialized substances is about 75 - 80%.

Use the same food leading to increased plasma bromhexine levels.

Distribution:

After using intravenous lines, Bromhexine is distributed quickly and widely throughout the body with average distribution (VSS) up to 1209 ± 206L (19 l/kg). The distribution has been studied into the lung tissue (bronchial and parenchyma) after taking 32mg and 64mg of bromhexine. The concentration of lung tissue after 2 hours of drug use, the concentration at the bronchial -sides tissue is 1.5 - 4.5 times higher and in the pulmonary parenchyma is about 2.4 - 5.9 times higher than the plasma concentration.

Bromhexlne binds in a constant form with plasma proteins about 95% (unlimited link).

Metabolism:

Bromhexine metabolizes almost completely into diverse hydroxy metabolites and into dibromanthanilic acid. All metabolites and bromhexine themselves are combined in the form of N - Glucuronides and O - Glucuronides. There is no significant evidence of changing the metabolic method due to sulphonamide, oxytetracycline or erythromycin. Therefore, the corresponding interaction is due to the CYP 450 2C9 and 3A4 substrate.

Era:

After using intravenous sugar, bromhexine has a high rate of extract within the range of blood to the liver, 843 - 1073 ml/minute, resulting in a large difference between individuals and on the same individual (CV> 30%). After using bromhexine with radioactive marking, about 97.4% ± 1.9% of the dose found in the form of radioactive in the urine, with the original active ingredient below 1%. Plasma bromhexine concentration decreases with exponent. After taking single -dose from 8 to 32 mg, the last half -life is in the range of 6.6 - 31.4 hours. Half -life relevant lifetime to predict multi -dose pharmacokinetics is about 1 hour, so there is no accumulation after multi -dose use (accumulation coefficient 1.1).

General:

Bromhexine represents pharmacokinetics proportional to the dose within 8 - 32 mg after oral use.

There is no bromhexine pharmacokinetic data on elderly patients, or patients with liver or kidney failure. Clinical experience does not show problems related to safety on these subjects.

There are no studies on interactive with oral anticoagulants or digoxin. Bromhexine's pharmacokinetics are not affected when used simultaneously ampicillin or oxytetracycline. The previous comparison did not see the corresponding interaction between bromhexine and erythromycin. There is no related interactive report for a long time for the circulation of drugs that suggest that the ability to interact is negligible with these drugs.

Before taking Bisolvon 8mg Boehringer is thin sputum, mucus (3 blisters x 10 tablets)

How to use

Bisolvon drugs for oral use.

Dosage

Adults and children over 12 years: 8mg (1 capsule) 3 times daily.

Children 6 - 12 years old: 4mg (1/2 tablets) 3 times daily.

Children 2 - 6 years old: 4mg (1/2 tablets) 2 times daily.

At the beginning of treatment may need to increase the total daily dose of up to 48 mg in adults.

Should notify patients treated with bisolvon about the ability to increase mucus secretion.

In an indication of acute respiratory disease, a doctor should consult if the symptoms do not improve or worsen during treatment.

It is not recommended to use bisolvon tablets for children under 2 years old. Bisolvon Kids syrup is more suitable for this age.

What to do when overdose?

Based on the overdose reports by accident and/or wrong medication, observation symptoms are suitable for the known side effects of Bisolvon at the recommended dose and may need symptom treatment.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Bisolvon 8mg, you may experience unwanted effects (ADR).

immune system disorders, skin and tissue disorders, breast disorders and mediasters:

Anaphylactic reaction includes anaphylactic shock, angioedema, bronchospasm, rash, urticaria, itching and other hypersensitivity.

Nausea, vomiting, diarrhea and abdominal pain.

Warnings

Contraindicated

Bisolvon 8mg should not be used for patients who already know how to be hypersensitivity to bromhexine or other ingredients of the drug.

Contraindicated in cases of rare genetic diseases may not be tolerated with an excipient of the drug.

Be cautious when taking drugs

There are very few serious skin damage reports such as Stevens - Johnson syndrome and poisoned epidemic epidermal necrosis (Ten) temporarily related to the use of phlegm as Bromhexine. Most cases are explained by the disease that the patient is suffering from and/or medication. Moreover, in the early stages of Stevens - Johnson or Ten, the patient first had a million -like influenza -like influenza like fever, human aches, rhinitis, cough and sore throat.

Due to being confused by these non -specific influenza, one can start treating symptoms by cough and colds. Therefore, if a few new lesions appear on the skin or mucosa, you should see a doctor immediately and stop treatment with bromhexine.

8 mg Bisolvon contains 222 mg of lactose for the maximum daily proposal (equivalent to 444 mg of lactose in case of double -dose in adults at the beginning of treatment). Patients with rare genetic diseases galactose such as congenital carbon metabolism should not be used.

The ability to drive and operate machinery

has not studied the effects of Bisolvon 8mg on driving and operating machinery.

Pregnancy

Data using bromhexine for pregnant women is limited.

Animal studies do not allow direct or indirect harmful effects to reproductive toxicity.

Should be cautious by avoiding using Bisolvon 8mg during pregnancy.

Breastfeeding period

It is unclear whether bromhexine/metabolites will be secreted into the mother's milk.

Data obtained in pharmacokic/toxicity on animals shows the excretion of bromhexine/metabolites into the mother's milk.

Cannot rule out the risk for breastfed babies, do not use bisolvon during breastfeeding.

Reproductive ability

has not conducted research on the effects of bisolvon 8mg on human fertility.

Based on preclinical experience, there is no sign that Bromhexine can affect fertility.

Medicinal interaction

Medicinal interaction can change the ability of the drug or increase the effects of side effects. It is best to write a list of drugs you are taking (including prescription, non -prescription and functional foods) and for doctors or pharmacists. Do not arbitrarily take the drug, stop or change the dosage of the drug without the permission of a doctor.

The drug does not recognize the interaction that is not beneficial to other drugs in terms of clinical.

Storage

You should store at room temperature, avoid moisture and avoid light. No storage in the bathroom or in the freezer. You should remember that each drug may have different storage methods. Therefore, you should read carefully storage instructions on the packaging or ask the pharmacist. Keep pills out of reach of children and pets.

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