Bisoplus HCT 5/12.5 Stella medicine for hypertension (3 blisters x 10 tablets)
Dosage form Box of 3 blisters x 10 tablets
Specifications Bisoprolol, hydrochlorothiazide
Ingredient Heart failure, high blood pressure
Ingredient
| Composition information | Content |
| Bisoprolol | 5mg |
| Hydrochlorothiazide | 12.5mg |
Uses
Indications
Bisoplus HCT 5 mg/12.5 mg drug is indicated in the following cases:
Bisoprolol is a selective inhibitor of receptor β1 - Adrenergic without significant membrane stability or internal sympathetic activity in the therapeutic dose range.
At low doses of Bisoprolol selectively inhibit the adrenergic stimulation by inhibiting the receptor competition β1 - adrenergic in the heart, while less impact on the receptor β2 - adrenergic in the bronchial muscles and blood vessels. At high doses, the selection of bisoprolol on receptors β1 - adrenergic usually decreases and will inhibit receptor competition β1 and β2 - adrenergic.
hydrochlorothiazid is a diuretics of benzothiadiazin.
The thiazids affect the reabsorption of the electrolyte of the renal tubules and increase the secretion of sodium and chloride in the equivalent amount. The excretion of sodium in urine causes secondary potassium.
Dynamic pharmacology
bisoprolol fumarat
absorption:
Bisoprolol is absorbed almost completely through the gastrointestinal tract and oral bioavailability about 90% due to the little metabolism through the liver very little. The peak concentration in plasma is achieved after drinking from 2 - 4 hours.
Distribution:
about 30% bisoprolol binds to plasma proteins. The drug has a semi-discharged time in plasma about 10-12 hours. Bisoprolol is moderate in lipid.
Metabolism and elimination:
The drug is metabolized in the liver and is eliminated in the urine, about 50% of the drug in the form of intact and 50% in the form of metabolites.
hydrochlorothiazid
absorption:
hydrochlorothiazid is absorbed quite quickly through the gastrointestinal tract. The drug has a bioavailability of about 65 - 70%.
Distribution:
Semi -selling time in plasma is about 5 -15 hours and priority is bound to erythrocytes.
Metabolism:
No information.
Era:
The drug is excreted mainly in urine in constant form. Hydrochlorothiazid through the placenta fence and is excreted into breast milk.
Before taking Bisoplus HCT 5/12.5 Stella medicine for hypertension (3 blisters x 10 tablets)
How to use
Bisoplus HCT 5 mg/12.5 mg oral, oral, orally with a glass of water in the morning.
Dosage
When using combined therapy in hypertension control, the first dose is adjusted by using each drug separately. If the dose is determined to maintain the goal corresponding to the ratio in the combined preparation, the combination can be used.
Adults
The usual dose is 1 tablet/day. When necessary, the dose may be increased to 2 tablets/day.
Patients with renal failure or liver failure: The dose should be reduced when taking the drug.
Children
Do not recommend using drugs because there is no research in children.
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.
What to do when using overdose?
Model data suggests that Bisoprolol Fumarat is not separated; Therefore, there is no appointment of hydrochlorothiazid separation. The common measure is proposed, including vomiting and/or gastric lavage, active carbon, respiratory support, adjusting water imbalance and electrolytes and treating convulsions. Based on the pharmacological effects that can occur and recommend with other beta blockers and hydrochlorothiazid, the following measures are considered when clinical signs:
Side Effects
When using Bisoplus HCT 5 mg/12.5 mg, you may experience unwanted effects (ADR).
bisoprolol fumarat
Unknown frequency:
Hematology: Hemorrhage. hydrochlorothiazide: Unknown frequency: Hematology: Anemia, granulocytes, leukocytes, blood anemia, thrombocytopenia. Hypersensitivity: Bleeding, light sensitivity, urticaria, necrotic vasculitis (vasculitis and skin capillary), fever, respiratory failure include pneumonia and pulmonary edema. Skin: Diverse roses include Stevens-Johnson Syndrome, Skin Peeling Inflammation including toxic epidermal necrosis. Special senses: fading eyes, seeing yellow. Instructions on how to handle ADR When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
Contraindicated
Bisoplus HCT 5 mg/12.5 mg is contraindicated in the following cases:
Patients with untreated heart failure or loss of heart failure, cardiac shock, atrial sinus block, atrial atrial block 2 or 3, clear slow heart rate (heart rate
Patients with hypersensitivity to bisoprolol or thiazid or sulphonamid or any ingredients of the drug.
Caution when using
bisoprolol fumarat
Although beta blockers are used in the treatment of heart failure, it is not used for patients with uncontrolled heart failure and when the treatment is started, it is necessary to be highly careful, so the starting dose starts and adjusts the dose carefully.
Use cautiously in patients with prolonged PR transmission, low heart reserve and peripheral circulatory disease as the raynaud phenomenon.
Use bisoprolol carefully in bronchial spasms (bronchial asthma, obstructive airway). In some asthma patients, an increase in airway resistance may occur and this is considered a sign of stopping treatment. Bronchospases can often be reversed due to regular use of bronchodilators like salbutamol.
bisoprolol does not impair carbohydrate metabolism but hidden hypoglycemic symptoms in diabetes patients.
Beta blockers can cover the symptoms of hyperthyroidism on thyroid poisoning patients.
Sudden stop treatment, bisoprolol can cause severe angina and/or myocardial infarction and ventricular arrhythmia in patients with coronary artery disease or may cause thyroid storms in patients to increase thyroid energy. Therefore, it is necessary to remind the patients who are using bisoprolol (especially ischemic heart disease) is not to stop the drug without consulting the doctor. Because coronary artery disease is common and may not be diagnosed, it is recommended to stop the drug suddenly in patients taking Bisoprolol to treat other diseases (such as hypertension). When bisoprolol is discontinued on people with coronary artery disease or suspected to increase thyroid ability, patients should be carefully monitored and advised to limit temporary physical activity.
If severe angina occurs or acute coronary artery failure after stopping the sudden treatment of bisoprolol, it should be stopped for at least a while.
hydrochlorothiazid
All thiazids should be used carefully in patients with water and electrolytes or people at risk of changing water and electrolytes, like the elderly.
Patients with cirrhosis are more likely to progress to hypoglycemia. Hypoglycemia can occur in patients with severe heart failure, especially patients with high doses of thiazids and limiting salt intake. The patient should be carefully monitored with signs of water and electrolyte imbalance, especially when vomiting or during the gastrointestinal solution. Patients with liver function or progressive liver disease are prone to liver coma.
Diuretics should be used carefully for kidney failure because the drug may reduce the kidney function. Most thiazid drugs are not effective in patients with creatinine clearance
Thiazids can promote gout on sensitive patients.
Hemorrhage increases blood glucose and worsen or reveal diabetes. Should adjust drugs to treat diabetes including insulin.
Thiazids reduce calcium secretion through urinary tract, sometimes leading to mild blood calcium hypercalcemia; The drug is not used for patients who have had hypercalcemia. The ability to thiazid worsens or activates systemic lupus erythematosus on sensitive patients. Thiazid may increase the risk of developing gallstones.
thiazid diuretics increase cholesterol and triglycerides.
The ability to drive and operate machinery
bisoprolol can cause side effects such as drowsiness, dizziness and fatigue, which can affect the ability to drive or operate machinery.
Pregnancy
Thiazids through the placenta fence and appear in the blood of the umbilical cord.
The use of thiazid for pregnant women requires aware of the benefits in advance with possible harm to the fetus. These dangers include death or jaundice, pancreatitis, thrombocytopenia and other side effects that have occurred in adults.
bisoprolol fumarat and hydrochlorothiazid during pregnancy only when potential benefits are higher than the risk of harmful to the fetus.
breastfeeding period
Thiazids are excreted through breast milk. A small amount of bisoprolplplppling (
Drug interaction
bisoprolol fumarat
Simultaneous use of rifampin increases the clearance of the metabolites of bisoprpli fumarat, shortening the sale time. However, the starting dose is usually unnecessary.
While using beta blockers, patients with a history of serious anaphylactic reactions to different allergens may react strongly to the use of repeated drugs, by accident, diagnosis or treatment. These patients may not respond to the usual dose of epinephrin who have treated allergic reactions.
hydrochlorothiazid
alcohol, barbiturates, or narcotic: may occur the possibility of hypotension.
Diabetes drugs (oral or insulin): may need to adjust the dose of diabetes medications.
Other hypertension medications: force impact.
cholestia and colestipol resin: the absorption of hydrochlorothiazid is reduced in the presence of anion exchange resin. The single dose of cholestyramin and colestipol resin bind hydrochlorothiazid and reduce the absorption of the drug in the gastrointestinal tract, up to 85% and 43%.
Corticosteroids, ACTH: aggravate the exhaustion of electrolytes, specifically lowering potassium.
Norepinephrin (norepinephrin): capable of reducing response to vascular amines but not enough to eliminate the use.
Bone muscle relaxants, non -reducing (tubocurarin): Ability to increase response to muscle relaxants.
Lithi: Usually not used with diuretics. Diuretics reduce lithium kidney clearance and increase high risk of lithium poisoning.
Nonsterooid anti -inflammatory drugs: In some patients, the use of nonsteroid anti -inflammatory drugs reduces diuretics, sodium diuretic and anti -hypertension effect of diuretics, diuretic that saves potassium, thiazide diuretics. Therefore, when using this product simultaneously with nonsteroid anti -inflammatory drugs, patients should be closely monitored to determine whether to achieve the desired diuretic impact.
Storage
In closed packaging, dry place, avoiding light. The temperature does not exceed 30 ° C.
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