Bisoprolol Stada 5mg medicine for hypertension, angina (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Bisoprolol
Ingredient Heart failure, high blood pressure, angina

Ingredient

Composition information	Content
Bisoprolol	5mg

Uses

Indications

Bisoprolol Fumarat is indicated in cases to control hypertension and angina. The drug is also used to combine standard therapy in patients with chronic heart failure.

Pharmacokology

Bisoprolol is a selective blockbuster Beta 1 - Adrenergic but has no membrane stability and does not have an intrinsic sympathetic nerve effect when used within the scope of treatment.

In low doses, Bisoprolol inhibits selectively responding to adrenergic stimulation by competing for the Beta 1 receptor blocker - Adrenergic of the heart, while less acting on the beta 2 receptor - Adrenergic of bronchial muscles and vascular walls. With high doses, the selective properties of bisoprolol on the beta 1 receptor - adrenergic usually drops and the drug will compete inhibiting both beta 1 and beta 2 receptors - Adrenergic.

Pharmacokological

Bisoprolol is absorbed almost completely through the gastrointestinal tract and oral bioavailability about 90% because the drug is less metabolized through the liver for the first time. Peak concentration in plasma is achieved from 2-4 hours after drinking. About 30% Bisoprolol binds to plasma proteins. Bisoprolol is a moderate solute in lipid. The drug is metabolized in the liver and is eliminated in the urine, about 50% of the drug in the form of intact and 50% in the form of metabolites. The drug has a semi -discharged time in plasma about 10 - 12 hours.

Before taking Bisoprolol Stada 5mg medicine for hypertension, angina (3 blisters x 10 tablets)

How to use

Bisoprolol 5 is taken orally.

Dosage

Hypertension or angina: The usual oral dose of Bisoprolol Fumarat is 5 - 10 mg x 1 time/day, the maximum dose is recommended for 20 mg/day.

Set congenital heart failure: The starting dose of Bisoprolol Fumarat is 1.25 mg x 1 time/day. If tolerated, the dose can be doubled after 1 week and then increase the dose slowly within 1-4 weeks to the maximum dose is tolerated, do not exceed 10 mg x 1 time/day.

Dosage for patients with liver and renal failure: The starting dose of Bisoprolol Fumarat for patients with hypertension 2.5 mg/day and increasing the dose slowly above patients with severe hepatic impairment or renal failure (creatinine clearance What to do when overdose?

Symptoms:

Slow heart rate, hypotension, congestive heart failure, trachea and hypoglycemia are the most common signs of Beta's overdose.

Management:

Normally, if overdose occurs, Bisoprolol stops and conducts supportive treatment and symptomatic treatment. There are a few data that suggest bisoprolol fumarat is not separated. Based on pharmacokinetics and recommendations for other beta blockers, consider general methods after seeing clinical signs:

Slow heart rate: Atropine intravenous injection. If not responded, use isoproterenol or another drug with a strong mechanical properties carefully. In some cases, pacemaker can be placed if necessary.

Hypotension: Intravenous fluid and use of hypertension drugs. Glucagon intravenous injection may also be helpful.

Atrial atria (degree II or III): careful monitoring of patients and treated by infusion of isoproterenol or pacemaker placing, if appropriate.

Sound heart failure: Starting conventional therapy (such as digitalis, diuretics, vasodilators).

Trachea spasm: Use trachea medications such as isoproterenol and/or aminophyllin.

Hypoglycemic blood glucose: glucose intravenous injection.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Bisoprolol 5, you may experience unwanted effects (ADR).

Central nervous system: dizziness, dizziness, headache, paresthesia, tactile reduction, drowsiness, anxiety, restlessness, reduction of capacity/memory.

Automatic nervous system: dry mouth.

Cardiovascular: Slow heart rate, suspense and other arrhythmia, cold -headed cold, balancing, hypotension, chest pain, congestive heart failure, shortness of breath.

Mental: Di dream, insomnia, depression.

Gastrointestinal: Gastrointestinal/abdominal pain, gastritis, indigestion, nausea, vomiting, diarrhea, constipation.

Neuropathy: muscle/joint pain, back pain/muscle, abdominal spasms, convulsions/tremor.

Skin: rash, eczema, skin irritation, itching, flushing, sweating, hair loss, angioedema, skin peeling, skin inflammation.

separate senses: visual disorders, eye pain/severe eye, abnormal tears, tinnitus, ear pain, abnormal taste.

Metabolism: gout.

Respiratory: Asthma/trachea, bronchitis, cough, shortness of breath, sore throat, rhinitis, sinusitis.

Urinary - genital: Reducing sexual activity/helplessness, cystitis, kidney cramps.

Hematology: rash.

Systemic: fatigue, weakness, chest pain, discomfort, edema, weight gain.

Warnings

Contraindicated

Bisoprolol 5 drugs are contraindicated in the following cases:

Acute heart failure or in the stage of loss of loss of heart failure requires muscle -oriented therapy. The center is less than 100 mmHg).

Precautions when taking drugs

Need to adjust Bisoprolol dose carefully for patients with liver or kidney failure.

heart failure:

Psychic stimulation is an essential component that supports circulatory function in the beginning of congestive heart failure and beta blockers can lead to further decline in cardiac contraction and promote worse heart failure.

Patients with no history of heart failure: The continuous inhibition of the heart muscle of beta blockers on some patients can cause heart failure. When there are signs and the first symptoms of heart failure, it is necessary to consider stopping the drug. In some cases, Beta blockers can continue to continue treating heart failure with other drugs.

Sudden stop treatment: severe angina and in some cases of myocardial infarction or ventricular arrhythmia in people with coronary artery disease after sudden stopping of beta blockers.

Peripheral vascular disease:

Beta blockers can cause or worsen artery anemia in patients with peripheral vascular disease.

Bronchospasm:

In general, patients with bronchospasm must not use beta blockers. However, due to the relatively selective properties Beta 1, caution can be used with bisoprolol in patients with bronchospasmic spasms that do not respond or unable to tolerate other anti -hypertension treatment. Because the selection of beta 1 is not absolutely, the lowest bisoprolol dose is possible, and starts at a dose of 2.5 mg. There must be a Beta 2 -maneuverbate (bronchodilator).

diabetes and hypoglycemia:

Beta blockers can cover the manifestations of hypoglycemia, especially tachycardia. Unstolant beta blockers may increase the level of hypoglycemia caused by insulin and slow down the recovery of serum glucose concentrations.

Due to the selective properties of beta1, this is less likely to occur with bisoprolol. However, it is necessary to warn patients or hypoglycemia, or people with diabetes using insulin or oral hypoglycemic medications for their ability and must use bisoprolol.

Thyroid hyperplation disease:

Beta blockers cover the clinical signs of hyperthyroidism such as fast heartbeat.

The ability to drive and operate machinery

Bisoprolol can cause unwanted effects such as drowsiness, dizziness and fatigue, which can affect the ability to drive or operate the patient's machines.

Pregnancy

There is no full and tight test in pregnant women. Bisoprolol is only used during pregnancy when proving the benefit of treatment than the potential risk to the fetus.

Breastfeeding period

Small amount of bisoprolol was discovered in mother mouse milk. It is unknown whether or not to excrete in human milk or not. Because many drugs are excreted on breast milk, they should be cautious when using bisoprolol for women who are breastfeeding.

Medicinal interaction

Patients who are taking drugs that exhausted catecholamine such as reserpin or guanethidin, should be closely monitored because of the impact of Beta - adrenergic inhibition force that can greatly reduce sympathetic activity. In patients being treated simultaneously with clonidin, if stopped treatment, bisoprolol should be discontinued a few days before stopping clonidin.

Be cautious when using Bisoprolol simultaneously with cardiac inhibitors or atrial inhibitors, such as calcium blockers [specifically like phenylalkylamin (verapamil) and benzothiazepine (diltiazem)] or arrhythmias such as disopyramid.

Concentrated with rifampicin increases the metabolism of bisoprolol, resulting in shortening the waste time of bisoprolol. However, it is not necessary to adjust the first dose.

Risk of anaphylaxis: During the use of beta blockers, patients with a history of anaphylactic reaction with different allergens may react stronger with the use of repeated drugs, by accident, diagnosis or treatment. Such patients may not respond to conventional doses of epinephrin used to treat allergic reactions.

Storage

You should store at room temperature, avoid moisture and avoid light. No storage in the bathroom or in the freezer. You should remember that each drug may have different storage methods. Therefore, you should read carefully storage instructions on the packaging or ask the pharmacist. Keep pills out of reach of children and pets.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.