Bivantox 300 Pharbaco oral medication supports the treatment of sensory disorders in patients with diabetes (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Alpha Lipoic Acid
Ingredient Central Pharmaceutical Joint Stock Company 1 - Pharbaco

Ingredient

Composition information	Content
Alpha Lipoic Acid	300mg

Uses

indications

Bivantox 300 tab drugs are indicated in the following cases:

Support treatment and prevent neurological complications, cataracts, infections, retinal degeneration, ... of diabetes. Acute necrosis, multiple sclerosis, alhzeimer disease.

Support and prevent stroke from stroke. Preventing hearing impairment in the elderly, hearing loss due to noise. Prevention and treatment of glaucoma. Born, the function of a co -enzyme in oxidation reaction forms the carbon dioxide of the ketoacid.

The hyperglycemia in diabetes is a result of glucose accumulation in the mother protein in the blood vessels and forming substances called the final products of the Glycosylation process (Ages: Advanced Glycosylation End Products). This process leads to a decrease in hemorrhagic blood flow and hypoxemia/hypoglycemia, combined with an increase in the production of free oxygen roots, which is recorded in peripheral nerves due to decreased antioxidants such as glutathion.

In mice studies, thioctic acid interacts with biochemical processes caused by mice with experimental diabetes caused by streptozocin through a decrease in the formation of Ages, improving the internal blood flow, increasing glutathione antioxidant levels and antioxidants for antioxidants for free oxygen roots in diabetic diabetes. The observed results under the experimental conditions show that the function of peripheral nerves can be improved by thioctic acid. This is related to sensory disorders in diabetic polyneuropathy can be manifested as sensory disorders, paresthesia such as hot, pain, numbness, cow ants.

Supplementing the previous clinical results in the treatment of symptoms of diabetes with diabetes with Thioctic acid, a central, controlled study with Placebo conducted in 1995 shows the beneficial effects of Thioctic acid found in symptoms of hot, simple, numb and painful symptoms.

pharmacokinetics

alpha - lipoic acid (acid thioctic) is quickly absorbed after drinking. Absolute bioavailability (when compared to intravenously) of Alpha Lipoic Acid approximately 20%. With rapid distribution results into the tissue in the body, the semi -cancellation time in the plasma of alpha - lipoic acid in humans is approximately 25 minutes.

The relative bioavailability of alpha -lipoic acid when used in solid form is 60% higher than the form of oral solution. The maximum concentration in plasma is approximately 4 µg/ml is measured about 0.5 hours after taking 600 mg of alpha - lipoic acid. Using radioactive marking methods in animal tests (mice, dogs) shows that the excretory sugar is mainly through the kidneys, accounting for large quantities (80 - 90%) in the form of metabolites. Only a small amount of unchanged substances found in urine. Biological changes occur mainly due to the chain oxidation (p - oxidation) and/or S - methylation of isotope.

on in vitro alpha - lipoic acid reacts with metal ionic complexes (as with cisplatin). Alpha - Lipoic Acid forms a hard -to -soluble complex with sugar molecules.

Before taking Bivantox 300 Pharbaco oral medication supports the treatment of sensory disorders in patients with diabetes (3 blisters x 10 tablets)

How to use

use by oral.

Bivantox 300 tab should take whole tablets with a sufficient amount of water when hungry. Food can reduce the absorption of the drug if used simultaneously. Therefore patients need to keep hungry.

Cases of diabetic neuropathy: a chronic disease, patients should be treated for a long time. The basic foundation of the treatment of complications of diabetic neuropathy is the optimal blood sugar control.

Dosage

Daily dose for adults is 2 tablets Bivantox 300 tab (corresponding to 600 mg of Alpha Lipoic acid) oral 1 time about 30 minutes before breakfast.

In the case of serious sensory disorders, the injection therapy with alpha lipoic acid can be conducted first.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? After intentionally or unintentionally drink large amounts of 10 to 40 g of alpha lipoic acid with alcohol, severe poisoning and sometimes death has been reported.

Signs of clinical poisoning can first manifest in mental disorders or consciousness disorders and typical development of general seizures and lactic acid infections.

In addition, reducing the amount of blood glucose, shock, muscle destruction, hemolysis, thrombosis of scattered vessels (dic), bone marrow weakening and multi -organ failure have been described as a result of high doses of alpha lipoic acid.

Treatment opinions in case of overdose

In case of suspicion of severe poisoning caused by Bivantox 300 Tab (such as a dose> 10 tablets 600 mg in adults and> 50 mg/kg of weight in children), it is necessary to immediately take patients to medical agencies with basic emergency conditions such as poisoning cases (such as causing vomiting, gastric wash, active charcoal use, etc.).

Treatment of general seizures, lactic acid infections and other life -threatening consequences due to drug poisoning should be done with modern supporting principles and need symptomatic treatment. The benefits of hemorrhage and peritoneal fertilizer or filtering methods to eliminate alpha lipoic acid have no solid results.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Bivantox 300 tab, you may experience unwanted effects (ADR).

Symptoms on gastrointestinal

Very rare: Nausea, vomiting, stomach pain, intestines and diarrhea.

Sensitive reaction

Very rare: allergic reactions such as rash, urticaria and itching.

Nervous system disorders

Very rare: Change and/or taste disorders.

Other undesirable reactions

Very rare: Because sugar consumption can improve in diabetes patients, hypoglycemia may occur. Symptoms similar to hypoglycemia have been described as dizziness, sweating, headache, visual change.

Instructions on how to handle ADR

Must stop alpha lipoic acid days if unwanted effects occur in the gastrointestinal tract, nervous system and other undesirable reactions that submit to alpha lipoic acid.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Bivantox 300 drug is contraindicated in the following cases:

Bivantox 300 tabs are absolutely contraindicated in patients who know how to be sensitive to alpha lipoic acid or any ingredients of the drug.

Because there are not many safety studies on young and minor children, so it should not be used for these subjects.

Be cautious when used

Do not use drugs for patients with genetic, non -absorbing fructose, Glucose - Galactose or Saccharase - Isomaltase deficiency.

The ability to drive and operate machinery

There is no report on the effect of the drug on the ability to drive or operate the user's machine.

Pregnancy

in accordance with the principles of pharmaceutical use, the product should only be used for pregnant women after careful consideration of the ratio between benefits and risks.

Pregnant women should treat Alpha Lipoic acid only when they follow the instructions of the physician, even if the toxicity studies for the reproductive system do not give any results affecting fertility and embryo development and there is no sign of toxicity to the fetus.

The period of breastfeeding

In accordance with the principles of pharmaceutical use, the product should only be used for breastfeeding women after careful consideration of the ratio of benefits and risks.

It is unknown whether alpha - lipoic acid is secreted into human milk or not.

Drug interaction

cisplatin is inactive when used simultaneously with bivantox 300 tab.

Alpha Lipoic acid is a metal complex so it should not be used simultaneously with metal compounds (such as iron, magnesium and dairy products containing calcium). If Bivantox 300 Tab is used daily 30 minutes before breakfast, iron and magnesium products can be used at noon or afternoon.

Hypoglycemic effects may occur when combined with insulin or other diabetes medications. Therefore, it is necessary to monitor blood sugar closely, especially in the early stages of alpha lipoic acid. In special cases, reducing insulin or oral diabetes treatment drugs is necessary to prevent the manifestations of hypoglycemia.

Regular use of alcohol is a high risk agent for the development and progress of neurological diseases, so it can reduce the success of treatment with Bivantox 300 Tab. Therefore, patients with diabetic neuropathy should be recommended to avoid alcohol for treatment.

Storage

In a dry place, avoid light, the temperature does not exceed 30⁰C.

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