Bloza Bluepharma treatment for hypertension (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Losartan
Ingredient Bluepharma- indústria farmacal

Ingredient

Composition information	Content
Losartan	50mg

Uses

indications

Bloza drugs are indicated in the following cases:

Treatment of hypertension. Used to lower blood pressure) does not seem to be appropriate. But if the heart failure is stable with a ACE inhibitor, it is not advisable to switch to Losartan. Losartan reduces the risk of stroke. Angiotensin-II is a substance produced in the human body, this substance is associated with blood vessel receptors and vascular contractions, which increases blood pressure.

Losartan prevents the connection of Angiotensin-II with their receptors so it is blocked by vasoconstriction, which reduces blood pressure. Losartan slows down the impairment of kidney function in high blood pressure patients with Type II diabetes.

pharmacokinetics

After drinking, Losartan absorbs well and initially metabolized through the liver thanks to the cytochrom P450 enzymes. Losartan's bioavailability is approximately 33%. About 14% of Losartan dose taken into activated metabolites, this substance is mostly antiotenic antagonism Angiotensin-II. Half of the lifetime of Losartan is about 2 hours and the metabolites are active within 3-4 hours.

Both Losartan and active metabolites are highly linked to plasma proteins, mainly albumin and they do not pass the blood -brain barrier. The distribution of Losartan is about 34 liters and of the metabolites with an activity of about 12 liters. Losartan's total plasma fronges of plasma are about 600 ml/minute and of an active metabolite of 50 ml/minute; Their clearance in the kidney corresponds to about 75 ml/min. After drinking Losartan marked 14C, collected about 35% of the radioactive in the urine and about 60% in feces.

In patients with mild to medium cirrhosis, the area under the curve (AUC) of Losartan and of the metabolic substance has a higher activity, corresponding, 5 times and 2 times higher than in patients with normal liver.

Before taking Bloza Bluepharma treatment for hypertension (6 blisters x 10 tablets)

How to use

oral medication.

Swallow the tablet with a cup of water. Try to take the medicine at the same time in the days. It is important that the patient must continue taking Losartan until the doctor told the patient about another drug.

Dosage

Hypertension in adults

Usually the treatment starts at a dose of 50mg of Losartan (1 tablet of Losartan 50mg), 1 time/day. The maximum hypotension effect will be achieved after 3-6 weeks of therapeutic start. Some patients with this dose may increase to 100mg of Losartan (2 Losartan 50mg tablets) per day. If you feel Losartan is too strong or too weak, tell your doctor or pharmacist.

Adults with hypertension and type II diabetes

usually treats at a dose of 50mg of Losartan (1 tablet of Losartan 50mg) per day. Dosage can increase to 100mg of Losartan (2 Losartan 50mg tablets) per day depending on your blood pressure response.

Losartan tablets can be used in combination with other antihypertensive drugs (such as diuretics, calcium inhibitors, alpha or beta inhibitors and central activity agents), as well as well with insulin and other common hypoglycemic drugs (such as sulfonylurea, glitazone and glucosidase inhibitors).

Heart failure in adults

Therapy usually starts at a dose of 12.5mg of Losartan per day. In general, the dosage may increase each week (for example, the dose of 12.5mg/day throughout the first week, 25mg/day during the 2nd week, 50mg/day throughout the 3rd week) until the maintenance dose of 50mg Losartan per day, depending on the patient's condition.

In the treatment of heart failure, Losartan is often combined with a diuretics and or digitalis (this drug makes the heart more and more effective) and/or a beta inhibitor.

Dosage for special patients

The doctor may recommend lower doses, especially when the therapy starts in patients who have taken high doses of dosage, in patients with liver failure or in patients over 75 years old. Do not use losartan for patients with severe liver failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? If you suspect an overdose, choose the medication immediately. Losartan's overdose information is limited. However, hypotension quickly quickly or slow heartbeat may be a sign of an overdose.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that double dose should not be used.

Side Effects

When using Bloza, you may experience unwanted effects (ADR).

Common, ADR> 1/100:

Dizziness, lower pressure, weakness, fatigue, hypoglycemia, hyperkalemia.

Uncommon, 1/1000

Sleeping, headache, sleep disorders, fast heartbeat, angina, hypotension (especially after reducing the internal volume, for example, patients with severe heart failure or being treated with high doses of diuretics), the effect of lowering pressure related to the dose appears while lying or sitting up, breathing, abdominal pain, persistent constipation, diarrhea, nausea, edema, edema.

Rare, 1/10000

Vascular inflammation (vasculitis including Henoch-Schonlein), numbness or nervous feeling of nerves (abnormal feeling), fainting, tachycardia and abnormalities, stroke, hepatitis, ALT concentration increased slightly (often lost when stopping treatment), not known, reduced red blood cells, platelet reduction, migraine, abnormalities, abnormalities, changes in abnormalities, changing abnormalities ( Treatment) including renal failure, symptoms of the flu.

Hyper urea, serum and potassium -driven creatinine in patients with heart failure, pain and urinary tract infections, increased sensitivity to light, muscle pain that cannot be explained with dark urine (tea color) (muscle globin, impotence, pancreatitis, reduce blood sodium levels in blood, depression, tinnitus.

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Contraindicated Bloza in the following cases:

allergies to Losartan or any ingredients of the drug.

Be cautious when using

Special monitoring and/or decreased dose in patients dehydrated, diuretic treatment and patients have other factors that can easily lead to hypotension. Patients with kidney stenosis on both sides or one side, only one kidney has a high risk of unwanted effects (increased creatinine and blood urea) and should be closely monitored in treatment.

For patients with renal function and older patients, they should regularly check the amount of potassium in the blood.

Patients with liver function: Losartan concentration and serum metabolites may increase, so the need for losartan's dosage for these patients.

Use in children: The safety and effectiveness of Losartan for children under 6 years old has not been proven.

The ability to drive and operate machinery

There is no mentioned document.

Pregnancy

Do not use Losartan for pregnant women because there may be a risk of pathological conditions for the fetus and death.

The period of breastfeeding. Should decide whether to stop breastfeeding or stop using Losartan is based on the importance of medication for mothers.

Medicinal interaction

Thiniazide diuretic: If used simultaneously Losartan with thiazide diuretic drugs, the effect of lowering blood pressure will increase.

Not used simultaneously Losartan with potassium -keeping pills.

Storage

In a cool dry place, room temperature, to avoid light.

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