Bluemoxi 400mg Bluepharma Treatment (7 tablets)

Dosage form Box of 1 blister x 7 tablets
Specifications Moxifloxacin
Ingredient Sinusitis, chronic bronchitis, pneumonia, skin infections

Ingredient

Composition information	Content
Moxifloxacin	400mg

Uses

indications

Bluemoxi 400mg Bluepharma 1x7 is indicated in the following cases:

Pneumonia is acquired in the community (with mild to medium level) caused by Streptococcus Pneumoniae, Haemophilus Influenzae, Mycoplasma Pneumoniae, Chlamydia Pneumoniae or Moraxella Catatrhalis. Eggs and endometritis) without ovarian abscess or pelvic abscess. Complicated abdominal infections include cases of bacterial infections caused by many bacteria such as abscess. The drug is effective in the treatment of skin infections such as unprocessed skin abscess, boils, impetigo and cellular inflammation. Staphylococcus aureus or Moraxella Catnrhalis.

moxifloxacin is an antibiotic of the fluoroquinolon group, which has bactericidal effects on both gram -positive and gram -negative bacteria by inhibiting Topoisomerase II and IV. Topoisomerase are essential enzymes that help regenerate, repair and copy bacterial DNA. The 1.8-napthyridin of moxymoxacin has 8-methoxy and 7-Diazabicylonyl-diazabicylonyl groups that increase the antibiotic effect and reduce the selection of Gram-positive anti-drug mutations.

Compared to ciprofloxacin, levofloxacin, and ofloxacin, moxifloxacin has better printing effects on streptococcus pneumoniae (including penicillin -resistant strains) and is equivalent to Gram -negative bacteria and non -pneumonia bacteria (Chlamydia pneumoniae, mycoplasma Pneumoniae, Legionella spp). Moxifloxacin works both in vitro and clinically with most strains of staphylococcus aureus (methicillin sensitive strains), Streptococcus pyogenes, Haemophilus influenza, H. parainfluenzae, Klebsiella Pneumoniae, Moraxella CatVrhalis, Chlamydiadiadia Pneumoniae, and Mycoplasma Pneumoniae.

moxifloxacin also works in vitro with staphylococcus epidermidis (sensitive to methicillin, streptococcus agalactiae, streptococcus pneumoniae (penicilin strain), Streptococcus viridans, enterobacter cloeacae Oxytoca, Legionella Pneumophila, Proteus Mirabilis, Fusobacterium spp), but so far the effect and safety of moxifloxacin for the above -mentioned bacterial infections have not been fully controlled.

pharmacokinetics

absorption and bioavailability:

After drinking, moxifloxacin is absorbed quickly and almost completely. The absolute bioavailability of the drug reaches about 91%.

Distribution:

moxifloxacin is quickly distributed to the vessels. Stable distribution volume is approximately 2 l/kg. Moxifloxacin mainly binds to serum albumin.

Metabolism:

moxifloxacin undergo phase II biological metabolism and are eliminated through the kidney and bile/fertilizer path in the form of non -metabolic drugs as well as sulpho complex (ml) and a glucuronid (m2).

Era:

moxifloxacin is made from plasma with the average half -life of approximately 12 hours.

Before taking Bluemoxi 400mg Bluepharma Treatment (7 tablets)

How to use

Drugs used by oral, can be used before, during or after eating.

Dosage

The dose is often used in adults

Take 400mg/day, drink 1 time.

Treatment time:

Having pneumonia in the community: 10 days.

No need to change the dose with people with renal failure (from mild to severe) and patients with dialysis. There is no enough data on dosage adjustment for patients with liver failure.

Children

Do not use moxifloxacin in children under 18.

Elderly and people can be low

No dose adjustment.

With patients from intravenous to oral infusion

Often oral for 4 days (with pneumonia is suffering from the community) or 6 days (skin infections and subcutaneous organization of complications).

The total treatment time for both intravenous and oral routes is 7-14 days with the infected pneumonia in the community, and from 7 to 21 days for skin infections and subcutaneous organization with complications, oral doses of 400 mg/day.

Abdominal infections have complications of the total number of serial treatments (first intravenous transmission then switch to oral): 5-14 days, Exacection of chronic bronchitis: 5 - 10 days, acute sinusitis due to bacteria: 7 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

How to handle: When overdose of moxifloxacin, there is no specific medicine for treatment, mainly symptomatic treatment and supportive treatment. Monitor the electrocardiogram for at least 24 hours because the QT can be extended or arrhythmia. The simultaneous use of activated carbon with a dose of 400 mg of oral moxifloxacin will reduce the bioavailability of the drug over 80%. The use of activated carbon early in the absorption process can be helpful to avoid excessive body contact with moxifloxacin in case of overdose.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Bluemoxi 400mg Bluepharma 1x7, you may experience unwanted effects (ADR).

Common, ADR> 1/100:

Infections: Bacterial or anti -drug fungus such as Candida fungus in the mouth and vagina.

nerve: headache, dizziness.

Cardiovascular: QT lasts in patients with hypotension. digestive: Nausea, vomiting, abdominal pain, diarrhea.

Uncommon, 1/1000

Hematology: Anemia, leukopenia, neutropenia, thrombocytopenia, thrombocytopenia, eucalyptus, eosinophilia, extended/INR prothrombin time.

immune: allergic reactions. Metabolism: hyperlipidemia.

Mental: anxiety, agitation.

Neurological: Perfect, Dharma, Disorders (including loss of taste but very rare), confusing and disorientation, sleep disorders (mainly insomnia), trembling, dizziness, dreaming condition. Cardiovascular: prolonged QT, brushing chest drum, tachycardia.

Rare, very rare, ADR

Immune shock: Anaphylaxis, very rare cases of life -threatening, edema/angioedema (including edema in the larynx, potentially life -threatening).

Metabolic: Hyperglycemia, hyperuricemia, hypoglycemia.

musculoskeletal: tendonitis, cramps, muscle seizures, muscle weakness.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Bluemoxi 400mg Bluepharma 1x7 contraindications in the following cases:

sensitive to moxifloxacin or other quinolones or any excipients of the drug.

Patients under 18 years old.

Pregnant and lactating women.

Patients with prolonged QT.

Patients with slow heart rate.

Patients with electrolyte disorders, especially patients with unprocessed hypokalemia.

Patients who are being treated with anti -arrhythmia IA (such as Quinidin, Procainamid) or Group III (such as Amiodaron, Sotalol).

Patients with a history of muscle tendon related to Quinolon treatment.

Heart failure with left ventricular blood reduction.

Do not use moxifloxacin simultaneously with drugs that extend the QT.

moxifloxacin is also contraindicated in patients with impaired liver function (Child Pugh C) and in patients with transaminase increased more than 5 times.

Be cautious when using

moxifloxacin should be used carefully in patients with continuous arrhythmia (especially women and the elderly), such as acute myocardial anemia or extended QT because this can lead to an increased risk of ventricular arrhyths and cardiac arrest. The extension level of QT can increase with increased drug concentration. Therefore, the recommended overdose should not be used. If signs of arrhythmia occur during treatment with moxifloxacin, treatment should be discontinued and must be redone ECG.

Hypersensic and allergic reactions have been reported to fluoroquinolones including moxifloxacin after first use. Anaphylactic reactions can progress to life -threatening shock, even after taking the first drug. In case of clinical manifestations of serious hypersensitivity reactions, moxifloxacin and appropriate treatment (for example, shock treatment).

Cases of acute hepatitis that can lead to liver failure (may cause death) have been reported to moxifloxacin. Patients should contact the doctor before continuing to treat if the signs and symptoms of acute liver disease progresses rapidly such as weakness related to jaundice, dark urine, tend to bleed or liver brain disease.

Serious body glossy skin reaction: cases of water glossy skin reactions such as Stevens-Johnson syndrome or poisoned epidermal necrosis were recorded with moxifloxacin. Patients should contact the doctor immediately before continuing treatment if the skin and/or mucosal reaction occur.

Patients with a history of epilepsy: Quinolon is known to cause seizures, need to be cautious when used in patients with central neurological disorders or another risk may cause epilepsy or reduce epilepsy threshold.

Peripheral neuropathy: Sensory or multi -nervous cases that lead to paresthesia, vision loss, difficulty reading or depression have been reported in patients using quinolones including moxifloxacin.

Mental reactions: Mental reactions can occur even after the first quinolon, including moxifloxacin. In rare cases of depression or mental reactions have progressed to the point of suicide thoughts and self -injuries such as suicide efforts.

Diarrhea related to antibiotics includes colitis: diarrhea related to antibiotics (AAD) and colitis related to antibiotics (AAC), including fake colitis and diarrhea related to Clostridium difficile, reported related to the use of broad spectrum antibiotics including moxifloxacin and may be at a serious level of mild diarrhea.

Patients with myasthenia gravis: moxifloxacin should be used carefully in patients with myasthenia gravis because the symptoms may be more serious.

tendonitis, tendon rupture: gingivitis and breaking (especially Achilles), sometimes it can occur with Quinolon treatment including moxifloxacin, even within 48 hours after the beginning of treatment and has been reported up to several months after the stop treatment. The risk of tendon and tendon can increase in elderly patients and in patients treated simultaneously with corticosteroids. When the first sign of pain or inflammation, patients should stop treating with moxifloxacin, the legs are damaged, so they should be sedentary and consult the doctor immediately for appropriate treatment (such as fixed) for the tendon to be affected.

Patients with renal failure: Elderly patients with renal dysfunction should use moxifloxacin caution if they cannot maintain the appropriate amount of liquid, because dehydration can increase the risk of kidney failure.

visual disorders: If vision is impaired or has any effect on the eye, advise an eye specialist.

Blood disorders: As for all fluoroquinolon, blood sugar disorders, including hypoglycemia and hyperemmic hyperglycemia, have been reported to moxifloxacin.

Prevention of sensitive reactions to light images: Quinolones have been shown to cause light sensitive reactions in patients.

Patients with glucose-6-phosphate dehydrogenase deficiency: Patients with a family history of glucose-6-phosphate dehydrogenase deficiency are actually prone to hemolytic reactions when treated with quinolones. Therefore, moxifloxacin should be used carefully in these patients.

Patients with galactose tolerance problems, Lapp lactase deficiency or glucose-Galactose malabsorption: recommendations should not be taken.

The ability to drive and operate machinery

Average effect: Precautions when used for drivers and machinery operation because of drugs because it can cause dizziness, dizziness.

Pregnancy

Because the risk of fetus is very large, therefore does not use moxifloxacin during pregnancy.

The period of breastfeeding

Precosessing experiment shows that moxifloxacin distributes small amounts into milk, so it is not used to use moxifloxacin for breastfeeding people because the drug can cause harm to children. In case it is necessary to use moxifloxacin, after considering the benefits - risks, it is necessary to stop breastfeeding during medication.

Drug interaction

should not coordinate moxifloxacin with any drug products that can extend the following QT range:

Anti -arrhythmia IA type (eg Quinidine, hydroquinidine, disopyramide). Haloperidol, Sultopride). mizolastine).

moxifloxacin should be used cautiously in patients taking drugs that can reduce potassium levels (such as thiazid diuretics and diuretics, laxatives and indented (high -dose), corticosteroids, amphotericin b) or drugs that can cause significant slow bradycardia.

Storage

In a cool dry place, avoid light, temperatures below 30 ° C.

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