Bostonex Boston medicine reduces allergic rhinitis, sneezing, runny nose, itching nose (3 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 3 blisters x 10 tablets
Ingredient Desloratadine
Indication Rhinitis, allergic rhinitis, sneezing, red eyes, stuffy nose

Ingredient

Composition information	Content
Desloratadine	5mg

Uses

Indications

Bostonex are indicated to reduce symptoms related to allergic rhinitis such as sneezing, runny nose and itchy nose, congestion, as well as itching, watery and red eyes, itchy throat and cough.

In addition, it is also indicated to reduce urticaria symptoms such as itching, size and number of rashes.

Pharmacokology

After drinking, desloratadine inhibits the H1 H1 receptor receptor on the periphery due to the non -absorbing drug into the central nervous system (CNS).

With a dose of 5 mg/day, the drowsiness rate is not higher than the placebo.

Do not observe clinical changes related to plasma desloratadin concentrations in multi -dose interactive tests with ketoconazol, erythromycin, azithromycin, fluoxetin and cimetidine.

Use at the same time with alcohol does not increase behavior weakness due to alcohol or drowsiness.

In patients with allergic rhinitis (AR), Desloratadin works to reduce symptoms such as sneezing, runny nose and itchy nose, nasal congestion, as well as itchy eyes, tearing and redness, itchy throat. Desloratadin controls symptoms effectively in 24 hours.

The release of histamine is a factor of urticaria, so the desloratadine is thought to be effective reducing symptoms for urticaria in addition to chronic urticaria.

pharmacokinetic

can quantify the plasma concentration of desloratadine within 30 minutes using desloratadine. Desloratadin is well absorbed with the maximum concentration achieved after about 3 hours, the selling time of the end of the end is about 27 hours. The accumulation of desloratadine is suitable for the disposal time of the drug (about 27 hours) and the dose once a day. The bioavailability of desloratadine is proportional to the dose of 5 mg to 20 mg.

Desloratadine is moderately cohesive (83% - 87%) with plasma proteins. There is no evidence of clinical accumulation after daily dosage (5 mg to 20 mg) in 14 days.

The yeast has not been determined to be responsible for transforming the desloratadine, and so it has not completely excluded a few interactions with other drugs. In vivo studies with specific inhibitors CYP3A4 and CYP2D6 have shown that these yeasts are not important in the metabolism of desloratadin. Desloratadin does not inhibit CYP3A4 or CYP2D6 and nor is the substrate or inhibitor P - Glycoprotein.

Food (high in fat, rich in calories) and grapefruit juice does not affect the pharmacokinetics of the desloratadine. Use single -dose desloratadine indicates that the form of preparation of film bags and syrup has the same biological effect and is not affected by food (high in fat, rich in calories).

Before taking Bostonex Boston medicine reduces allergic rhinitis, sneezing, runny nose, itching nose (3 blisters x 10 tablets)

This drug is only used as prescribed by a doctor. The dose is adjusted according to the needs of each patient.

How to use

is used by oral, or without meals.

Dosage

Adults and adolescents (> 12 years old): Take 1 capsule 1 time/day.

Non -continuous allergic rhinitis (symptoms that appear In prolonged allergic rhinitis (symptoms appear> 4 days/week and last> 4 weeks), can be treated continuously during exposure to allergens.

What to do when overdose? Symptomatic treatment should be treated and supported. On a multi -dose clinical study in adults and young people using desloratadine up to 45 mg (9 times higher than the clinical dose) did not observe the clinical manifestation of the overdose.

Desloratadine is not excreted through hemolysis: It is unclear whether it is excreted through peritoneal.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

With indications for allergic rhinitis and chronic urticaria, with a dose of 5 mg/day, the adverse effects are reported by Bostanex film bags reported in 3% of patients and higher than patients using Placebo.

The most common:

fatigue (1.2%).

dry mouth (0.8%).

Hypersensitive reaction (including anaphylaxis and rash). At 11 years of age in both groups using Bostonex Siro and Placebo, in children and children from 6 to 23 months, the most common adverse effects are reported more than Placebo are diarrhea (3.7%), fever (2.3%) and insomnia (2.3%).

Warnings

Before using the drug, you need to read the instructions carefully and refer to the information below.

Contraindicated

Bostonex 5 mg drug is contraindicated in case of hypersensitivity to the active ingredient or any ingredient of the drug.

Precautions when taking drugs

Not evaluating the safety and effectiveness of desloratadine tablets in children under 12 years old.

The ability to drive and operate machinery

does not observe that it affects the ability to drive and operate machinery.

Pregnancy and nursing mothers

generally do not see the fertility in mice with Desloratadine dose 3 - 4 clinical dose proposed for humans.

No observations of monitoring or gene mutations in animal tests using desloratadine. Because there is no clinical data on the use of desloratadine during pregnancy, the safety of desloratadine has not been determined during pregnancy. Do not use desloratadine during pregnancy unless the benefits are out of risk.

Do not use desloratadine for nursing women due to desloratadine to be secreted into breast milk.

Drug interaction

does not observe the clinical interaction with Bostonex in clinical trials.

Food or grapefruit juice does not affect the pharmacokinetics of the desloratadine.

Drinking desloratadine with alcohol does not increase the risk of alcoholic behavior.

Storage

In the dry place, the temperature does not exceed 30 ° C. Avoid direct light.

Do not use drugs beyond the expiry date.

to be out of reach of children.

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