Boxorfen Korea Prime Pharm treat stomach ulcers, gastritis (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Rebamipide
Ingredient Korea Prime Pharm

Ingredient

Composition information	Content
Rebamipide	100mg

Uses

indications

Boxorfen Tablet is indicated in the following cases: stomach ulcers and gastritis.

Pharmacokic

Repamipid is a drug that protects the stomach and has a different mechanism from the stomach acid secretion inhibitors. The drug increases and improves the healing of ulcers and reduces the likelihood of stomach ulcers. The main mechanism of acting of Repamipid is to stimulate prostaglandin production and glycoprotein mucus, inhibit oxidative free radicals, inhibit cytokin and chemokin causing inflammation, inhibit neutral white blood cell activity.

Dynamic pharmacokinetics

Plasma concentration in plasma

The following table indicates Rebamipid's pharmacokinetic parameters after taking a single dose of Boxorfen 100 mg tablets in 27 healthy male patients.

The pharmacokinetic parameters of Rebamipid:

Boxorfen

Tablet 100m9

TMAX (hour)

cmax (mcg/l)

t1/2 (hours)

auc24h (mcg/l.

2.4 1.2

216 79

1.9 0.7

874 209

Rebamipid absorption rate tends to be slow when the drug is taken orally at a dose of 150 mg for 6 healthy people after a meal compared to the absorption rate if taken before eating. However, food does not affect the bioavailability of the drug in humans.

The pharmacokinetic parameters recorded from patients with renal failure after taking a single dose of 100 mg of Rebamipid shows higher plasma concentrations and longer selling time than in healthy people. In a stable state, Rebamipid concentration in mental hemorrhage is observed in patients with renal fertilizer after the dose is repeated very similar to the values when using a single dose. Therefore, the drug is considered not accumulated.

Metabolism

After giving healthy adult men with a single dose of 600 mg, Rebamipid is mainly excreted in urine in the form of constant drugs. A metabolite has a group of hydroxyl in the 8th place that has been found in the urine. However, this metabolic secretion is only 0.03% of the dose used. The enzyme related to this metabolic formation is Cytochrom P450 3A4 (CYP3A4).

(Note) The common dose used in adults is 100 mg, 3 times/day.

Elimination

When healthy men use a single dose of Rebamipid 100 mg, about 10% of the doses were excreted in the urine.

Before taking Boxorfen Korea Prime Pharm treat stomach ulcers, gastritis (10 blisters x 10 tablets)

How to use

oral medication.

Dosage

Rebamipid dose is commonly used for adults is 100 mg (1 Boxorfen 100 mg) 3 times/day by oral in the morning, evening and before going to bed.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Symptomatic treatment should be treated.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Boxorfen Tablet, you may experience unwanted effects (ADR).

Of the 10,047 patients treated, unwanted effects appear on 54 patients. The frequency of unwanted appearance is less than 1% including: hypersensitivity reaction (rash, itching), digestive effect (digestive, abdominal distention, vomiting and nausea).

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Boxorfen Tablet is contraindicated in cases where patients have a history of hypersensitivity to any component of the drug.

Be cautious when using

used for the elderly: Pay special attention to elderly patients to minimize the risk of stomach disorders, because of physiological, elderly patients are often more sensitive to this drug compared to young patients.

Use for children: Not yet determined the safety of this drug in mild birth weight, newborns, breastfed and children (not clinical experience).

Be cautious when using: Instructions for patients.

Instructions for patients should not be swallowed any part of the compression (PTP) (have reported as sharp edges of the drug that can be cut or penetrated through the esophagus mucosa if unintentionally swallowed, leading to ventricular inflammation or other serious complications).

The ability to drive and operate machinery

There has been no study that has been controlled by the effect of Boxorfen 100 mg tablets when driving. A number of patients have been recorded dizziness or drowsiness while taking Boxorfen 100 mg, such patients need to be cautious when driving or operating machinery.

Pregnancy

Rebamipid should only be used for pregnant women or likely to be pregnant if the benefit of the estimated treatment is thought to be higher than any risk that may be (unknownly the safety of this drug in pregnant women).

The period of breastfeeding

Women who are breastfeeding must stop breastfeeding before using Rebamipid (mice studies show that rebamipid is excreted in milk).

Interactive drug

no drug interactions have been recorded.

Storage

Store at a temperature not exceeding 300C, avoiding light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.