Breakin Davi Pharm Treatment Treatment of depression disorders (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Bupropion
Ingredient Depression

Ingredient

Composition information	Content
Bupropion	150mg

Uses

indications

Breakin 150 drugs are indicated in the following cases:

Treatment of depression disorders.

Preventing seasonal depression stages mainly in patients with seasonal emotional disorders. In case the patient does not respond or intolerant, antidepressants can be used. Data from the above studies shows that BuPropion is effective in adults and children in this case. In Bupropion, the ability to inhibit dopamine reabsorption is twice as stronger than the ability to inhibit norepinephrine reabsorption. Besides, Bupropion also releases dopamine and norepinephrine. Bupropion quickly transforms the body into some metabolites with different activity.

It is measured in connection with dopamine transport (dat - dopamin transportter) of bupropion and its metabolites in the human brain is 6-22%. Similar to serotonin reabsorption inhibitors, the main mechanism of the drug is to inhibit more than 50% of the set to achieve dopamine reabsorption inhibitors. On the contrary, it takes about 65% or higher than the occupied DAT to achieve the state of excitement and likely to cause abuse.

However, recent research shows that dopamine is inactivated by norepinephrine reabsorption in the front cortex, where there is a large amount of dopamine transportation, so Bupropion can increase dopamine neurotransmitter in this part of the brain and this can be an explanation for other dopaminergic effects. BuPropion does not inhibit monoamine oxidase or reabsorbing serotonin. Bupropion also acts as an non -competitive nicotinic antagonist. Chronic treatment with bupropion can lead to a decrease in motor activity.

Mechanism of action:

bupropion is an antidepressant in the aminoketon group, there is no chemical relationship with 3-4 -round antidepressants. It inhibits the capture of Neuron Serotonin, norepinephrine and re -grasp Neuron Dopamine, so it is resistant to depression and helps the custody avoids the shortage due to the lack of stimulants, causing excitement like nicotine. Use BuPropion to support cai after 12 months for the success rate of two times higher than that of non -use of Bupropion.

bupropion is a selective inhibitor of Catecholamine reabsorption (noradrenaline and dopamine) with a minimum effect when reabsorbing indolamine (serotonin) and not inhibiting monoamine oxidase. Bupropion mechanism helps patients smoking unknown. However, it is thought that this effect is intermediate by the noradrenergic and/or dopaminergic mechanisms.

pharmacokinetic

absorption

bupropion is well absorbed through the gastrointestinal tract but can be metabolized for the first time. Some of the metabolites of BuPropion have a pharmacological activity and have a longer half -life and achieve higher plasma concentrations than the original compound.

Distribution

bupropion is attached to plasma proteins about 80%. The semi -cancellation time in the plasma of the instantaneous release is about 14 hours.

Metabolism

HydroxybuBupropion is the main metabolic substance, due to the metabolic bupropion through the isenzyme Cytochrome P450 CYP2B6. In Vivo, Hydroxybupropion with a force of half of the Bupropion. Threeohydrobpropion and erythroprobudrobudropion are created through reducing reactions and is active in 1/5 of the original compound.

Elimination

BuPropion's metabolites are excreted mainly in urine, less than 1% of the drug is excreted in the form of non -metabolic. Bupropion and its metabolites are given the placenta and are distributed into breast milk.

Before taking Breakin Davi Pharm Treatment Treatment of depression disorders (3 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

Treatment of depression:

Starting dose 100 mg x 2 times/day. Increase to 100 mg 3 times/day after at least 3 days if necessary. In serious cases, if not improved after a few weeks of treatment, the dose may increase to up to 150 mg 3 times/day.

Patients with liver failure:

When treating depression, the reduction of frequency and/or dose of bupropion should be considered in mild to medium to medium liver failure patients. In patients with serious cirrhosis of Bupropion maximum doses of 75 mg x 1 time/day.

Patients with renal failure:

In treatment for depression, reducing the frequency and/or dose of bupropion should be considered. The recommended dose in these patients is 150 mg once a day.

Children: There is no research on the use of bupropion to treat depression for children. Do not use drugs for patients under 18 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? About one -third of the case of BuPropion overdose occurs.

Handling: Considering the use of activated carbon in adults using more than 450 mg and all children, if emergency for 1 hour after taking the drug. Stomach lavage can also be used to reduce absorption. Support treatment. Benzodiazepin can be used to treat convulsions.

Diuretic, hemorrhage and absorbent absorption seem to be ineffective.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Breakin 150, you may experience unwanted effects (ADR).

agitated, worried and insomnia often occur in the first stage of Bupropion treatment. Unwanted unwanted effects: fever, dry mouth, headache or migraine, dizziness, urinating many times, vomiting and nausea, constipation, tremor, sweating and skin rash. Hypersensitivity reactions such as itching, urticaria, angioedema, shortness of breath and anaphylactic reaction have occurred.

Rarely reports Stevens - Johnson and Hong Ban syndrome. Heart rhythm, chest pain, hypertension (sometimes serious), vasodilation, hypotension standing, hitting chest drum, fainting, mental disorder, confusion, nightmares, memory loss, taste disorders, anorexia accompanied by weight loss, abnormalities, tinnitus, visual disorders.

Hypotenia hyponatremia, possibly due to the inappropriate anti -urinary hormone secretion when using antidepressants, especially in the elderly.

Convulsions, part of the dose dependence, may occur when using Bupropion, especially noticeable in patients with mental anorexia, mental eating, patients with a history of convulsions or other susceptible factors. The frequency of epilepsy occurrence in patients using the recommended doses is about 0.1 - 0.4%.

Cardiovascular: Heart beat fast, arrhythmia, myocardial infarction, angina, and cardiac arrest; Chest pain, chest tightness.

Cerebral vascular system: Perception, dizziness, tinnitus, confusing, gait disorders after using Bupropion to quit drugs.

Pancreatic: Pancreatitis and the activity of pancreatic enzymes are 3 times higher than usual.

Skin: Diverse roses, severe psoriasis, acute urticaria and flu symptoms.

Output effects: speculative and neck disorders; The unconscious movement of the body, arms and legs.

Hypersensitivity: Hydronephrosis, serum or serum similar symptoms

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Breakin 150 drugs contraindicated in the following cases:

Epilepsy disorders. Drugs.

Caution when using

bupropion can cause seizures and thus contraindication to patients with epilepsy. The drug is also contraindicated in patients with a history of mental or mental appetite and in patients who are in the sudden stop of alcohol or benzodiazepin because they can cause higher seizures.

It is necessary to be very careful in patients with a history of convulsions or other risk factors such as severe cirrhosis or central nerve tumors. Bupropion should only be used in patients with other risk factors for seizures (alcohol abuse, a history of head injury, diabetes and drug use reduces epilepsy threshold) when reasonable clinical reason is reasonable.

Be cautious when using BuPropion in patients with bipolar disorder or mental disorders because of the risk of rising, used to quit smoking in the above subjects can be contraindicated. The drug should also be used carefully in patients with a history of myocardial infarction or recent unstable heart disease and in patients with liver or kidney failure. When using BuPropion for depression, patients should be closely monitored from the beginning of the treatment process to notice a significant improvement to prevent suicide, a risk inherent in depression. The thoughts and behaviors can also occur in the early stages using antidepressants to treat other disorders, so be cautious.

To be out of reach of children.

The ability to drive and operate machinery

with drugs that affect the central nervous system, the ability to drive or operate machinery can be affected. Therefore, patients who are affected should not drive or operate machinery.

Pregnancy

Classification of pregnancy according to FDA

Safety for pregnant women has not been verified. The risk for the fetus and the benefits of the mother should be carefully considered when deciding on treatment. If required to use, need to be cautious and monitor regularly during treatment.

Breastfeeding period

The drug with breast milk, the effects of bupropion on breastfed babies are unknown, no unwanted effects are reported. However, be careful when using the drug in breastfeeding women.

Drug interaction

Mental unwanted mental reactions or alcohol intolerance may occur. Minimize or avoid drinking alcohol while using Bupropion.

Collaborate with Amantadin, Levodopa can increase Bupropion's undesirable reaction. Initially, small doses should be used with bupropion then increased the dose less and slowly.

Carbamazepin, CYP2B6 (Efavirenz, Phenobarbital, Phenytoin, Rifampin) can reduce serum bupropion concentration. Clinically monitor and adjust the doses of bupropion when necessary or stop the other drug.

Cyclosporin levels may be reduced when combined with bupropion. Clinically closely monitored and cyclosporin levels when starting or stopping using bupropion.

Metabolic drugs by CYP2D6 (Desipramin, Flecainid, Haloperidol, Iloperidon, Imipramin, Metoprolol, Nortriptylin, Propafenon, Risperidon, Tamoxifen, Thioridazin): The concentration of these drugs may increase due to buildion. Use carefully and adjust the dose of this drug when necessary.

Scrambling reduction drugs (antidepressants, anti -psychotic drugs, steroids, theophyline, tramadol): extremely cautious when combined with bupropion due to bupropion related to the risk of convulsions dependent on dosage. Need to start with low doses and gradually increase the dose.

The drug may increase the risk of convulsions (cocaine addiction, opium, stimulants, diabetics treated with hypoglyc or insulin medications, using too much alcohol or sedation) when used simultaneously with bupropion. Need to be careful and carefully monitor patients.

guanfacin: increases the risk of bupropion toxicity. Closely monitor patients.

CYP2B6 inhibitors (cimetidin, clopidogrel, ticlopidin) may increase the concentration of plasma bupropion and the risk of unwanted reactions. Bupropion dose should be adjusted when starting or stopping CYP2B6 inhibitors.

Contraindicated BuPropion with maoi, Linezolid can increase the risk of acute bupropion toxicity. Stop MAII at least 14 days before starting Bupropion. Avoid using BuPropion and Linezolid simultaneously.

Nicotine instead of shared therapy with bupropion can cause hypertension. Monitor patient blood pressure.

Ritonavir may reduce the plasma concentration of bupropion, which leads to reduced effects. Watch for clinical response and adjust the dose of bupropion if needed.

bupropion can inhibit the metabolism of some SSRIs (fluoxetin, paroxetin, sertralin), increasing their plasma concentrations. If BuPropion is added to the SSRI's treatment regimen metabolized through CYP2D6, considers the dose reduction. In addition, the risk of serotonin syndrome may increase. Closely monitor the clinical response and adjust the treatment regimen when necessary.

Tiagabin may increase the risk of convulsions when sharing bupropion. Should consider replacing one of the two drugs.

Rarely change the time of prothrombin and INR combined with complications of hemorrhage or thrombosis when shared with bupropion with warfarin. Monitor the effects of anticoagulant drugs and adjust the dose of warfarin when needed.

Storage

In a cool, dry place, below 30 ° C

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