Brodicef 250 Ha Tay treat infection (2 blisters x 15 tablets)
Dosage form Box of 2 blisters x 15 tablets
Specifications Cefprozil
Ingredient Tonsillitis, pharyngitis, otitis media, sinusitis, skin infections and soft tissue, acute bronchitis, chronic bronchitis, pneumonia
Ingredient
| Composition information | Content |
| Cefprozil | 250mg |
Uses
Indications
Brodicef 250 mg is indicated for treatment of mild infections to the average caused by sensitive bacteria strains as listed as below:
Upper respiratory tract:
Skin and structure: Skin infection and uncomplicated structure due to ST. Aureus (including parameters penicillinase) and St. Pyogenes. Surgery should be performed in cases of abscess.
Pharmacokology
bacteria:
In vitro, Cefprozil is a broad -spectrum antibiotic that works with Gram -positive and gram -negative bacteria. The bactericidal effect of Cefprozil due to inhibiting the synthesis of bacterial cell walls. In vitro, the drug works with most of the following bacteria:
Aerobic gram -positive bacteria:
Gram -positive aerobic bacteria:
Gram -negative aerobic bacteria:
Anaerobic bacteria:
Dosage
Average peak concentration Cefprozil in plasma (µg/ml)
Excretion through urine for 8 hours
4 hours
8 hours
6,1
1.7
0.2
60%
500 mg 10.5 3.2 0.4 62%
1,000 mg 18.3 8.4 1.0 54%
The cohesion with plasma protein is about 36% and does not depend on the concentration of the drug in the range of 2 µg/ml to 20 µg/ml. Half of the average decomposition in plasma in normal people is 1.3 hours.
There is no evidence of the accumulation of Brodicef in plasma in people with normal kidney function after taking multiple doses of 1 g every 8 hours in 10 days.
In patients with impaired renal function, half -life decomposed in a prolonged plasma related to the level of kidney dysfunction. In patients completely losing the kidney function, half -life decomposed in the plasma of Brodicef lasting up to 5.9 hours. While hemorrhage, half -life is shortened to 2.1 hours.
The average area under the curve (AUC) in elderly patients (> 65 years old) is higher in young people about 35-60% and the average AUC in women is about 15-20% higher. In terms of pharmacokinetics of Brodicef, the difference in age and gender does not mean the correlation to adjust the dose.
In patients with liver function failure, there is no statistically significant difference in pharmacokinetic parameters compared to normal controlled subjects.
After taking a single dose of 7.5 mg/kg or 20 mg/kg for patients to cut tonsils, the drug concentration in tonsils 1-4 hours after use is in the range of 0.4-4 Ug/g. This concentration is at least 25 times higher than the concentration of inhibition (MIC) for S.Pyogenes.
Before taking Brodicef 250 Ha Tay treat infection (2 blisters x 15 tablets)
How to use
"Brodicef 250 mg Ha Tay" oral.
Dosage
Adults (13 years or older)
Sore throat/ammidan: dose 500 mg, once a day. Treatment for 10 days.
Acute sinusitis (average to severe level can be used higher doses): Dosage 250 mg or 500 mg, twice a day. Treatment for 10 days.
Secondary infection in case of acute bronchitis or exacerbation of chronic bronchitis: dose of 500 mg, twice a day. Treatment for 10 days.
Dermatitis and incomplete structure: Dosage 250 mg, twice a day or 500 mg, 1 or 2 times a day. Treatment for 10 days.
Patients with renal failure
Creatinine clearance from 30 - 120 ml/minute: No dose adjustment.
Creatinine clearance from 0 - 29 ml/minute: The dose is equal to the standard dose.
Patients with liver failure: No dose adjustment.
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.
What to do when overdose?
Single dose 3000mg/kg causes diarrhea and reduced food in monkeys but does not cause death.
cefprozil excreted mainly through the kidneys. In some cases of severe poisoning, especially patients with kidneys, dialysis can be used to remove Cefprozil from the body.
What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.
Side Effects
When using Brodicef 250 mg, you may experience unwanted effects (ADR).
Common, ADR> 1/100
Liver: increase AST, Alt, alkaline phosphatase and bilirubin, jaundice. Hypersensitivity: ban, urticaria. Other: rash and superinfection, genitals and vaginitis. Uncommon, 1/1000 Rare, 1/10000 Instructions on how to handle ADR When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
Contraindicated
Brodicef 250 mg is contraindicated in the following cases:
Be cautious when using
to check if the patient has a history of allergies to Cefprozil, Cephalosporins, Penicillin or other drugs before appointment of cefprozil treatment. Caution should be careful when treated with cefprozil for patients allergic to penicillin because they may be crossed allergies. The drug must be stopped if the patient has an allergy. In severe cases, epinephrine may be indicated in combination with other supportive treatments.
Fake colitis has been reported to most antibiotics including Cefprozil, so it should be noted this diagnosis in patients with diarrhea due to antibiotics.
Antibiotic treatment changes the intestinal microflora and can increase Clostridia.
Studies show that C. Difficile toxicity is a major cause of antibiotic colitis.
Patients should be appropriate treatment if diagnosed with fake colitis. Mild cases just use the drug, the disease may end.
For patients with or suspected kidney failure, clinical monitoring must be monitored and conducted subclinical tests suitable before and after treatment. Reduce Cefprozil's daily daily dose with these cases. Caution should be careful when indicating cephalosporins, including cefprozil, for patients who are taking diuretics due to kidney function.
Be careful when indicating Cefprozil for patients with a history of intestinal disease, especially colitis.
The positive reaction to the direct Coombs test has been reported when using cephalosporin antibiotics.
The ability to drive and operate machinery
Patients may get dizzy when taking the drug. Therefore, it is necessary to warn the patient about this side effect if they drive or operate the machine when treated withceprozil.
Pregnancy
toxic trials on the fetus in mice, rabbits using Cefprozil oral oral doses of 0.8: 8.5 and 18.5 times the maximum dose in people who do not record harmful to the fetus. However, due to no human evidence, the use of drugs for women during pregnancy is only needed.
Breastfeeding period
A small amount of drugs (less than 0.3%, dose) was found in breast milk when the mother took the drug at a single dose of 1 gram. The average drug concentration for 24 hours is from 0.25 to 3.3 g/ml. Be careful when taking drugs for pregnant women because of the effects of drugs on unknown infants.
Medicinal interaction
Kidney toxicity has been reported when using Aminoglycoside antibiotics with cephalosporin at the same time.
Probenecid doubled Cefprozil's AUC when used simultaneously.
Birth of Cefprozil is not affected when taking an antacid medicine 5 minutes.
Cephalosporin antibiotics cause false positive phenomenon in urine trial tests with Fehling or Benediet reagents but affect the test results of enzymes such as clinistix. The false negative reaction can occur with Ferricyanide test to check blood sugar.
cefprozil does not affect the quantification of creatinine in the blood or urine by alkaline picrat.
Storage
In a cool dry place, the temperature does not exceed 30 ° C, in a closed package.
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