Brodicef 500 Ha Tay medicine for infection (3 blisters x 10 tablets)

Secondary infections in the case of acute bronchitis or exacerbation of chronic bronchitis caused by St Pneumoniae, H. Influenza (including seminarians β-lactamase), and Moraxella (Branhamella) CatVrhalis (including seminarians β-lactamase).

Skin and structure:

Skin infections and uncomplicated structures due to ST. Aureus (including parameters penicillinase) and St. Pyogenes. Surgery should be performed in cases of abscess.

Pharmacokology

Description: Cefprozil is Cephalosporin for the second generation, semi -synthetic, with wide antibacterial spectrum.

Bacteria learn:

In vitro, Cefprozil has an anti -bacterial and Gram -negative effect.

In vitro, the drug works against most of the following bacteria strains:

Gram (+) aerobic bacteria:

The following bacteria strains are resistant to cefprozil: Staphylococci resistant to methicillin, EnterococcusfusfusfiCium, most acinetobacter strains, entobacter, Alorganella Morganii, Provideneia, Pseudomonas, and Serratia, most Bacteroides Fragilis strains.

Mechanism of action:

Cefprozil is an oral, semi -synthetic cephalosporin antibiotic, 2nd generation, has the effect of killing bacteria that are growing and dividing by inhibiting synthesis of bacterial cells.

Dynamic pharmacokinetics

After drinking at full or hungry, Cefprozil all absorb well. Cefprozil's (absolute) bioavailability when drinking is 90%. The pharmacokinetics parameters of the drug are not affected when using the drug at full or simultaneously used with antacids. The average peak concentration in plasma after using Cefprozil for patients at hunger is presented in the table below.

About 65% of the dose is excreted in a constant urine. In the first 4 hours after the drug, the average concentration in the urine after the dose of 250 mg, 500 mg and 1 g respectively is about 170 µg/ml, 450 µg/ml and 600µ g/ml.

The cohesion with plasma protein is about 36% and does not depend on the concentration of the drug in the range of 2 µg/ml to 20 µg/ml. Half of the average decomposition in plasma in normal people is 1.3 hours.

There is no evidence of the accumulation of cefprozil in plasma in people with normal kidney function after taking multiple doses of 1 g every 8 hours in 10 days.

In patients with impaired renal function, half -life of prolonged plasma is related to the level of renal dysfunction, in patients completely losing renal function, half -life decomposition in plasma of Cefprozil lasts up to 5.9 hours. While hemorrhage, half -life is shortened to 2.1 hours.

The average area under the curve (AUC) in elderly patients (> 65 years old) is higher in young people about 35 - 60% and the average AUC in women is about 15-20% higher. In terms of pharmacokinetics of Cefprozil, the difference in age and gender does not mean the correlation to adjust the dose.

In patients with liver function failure, there is no statistically significant difference in pharmacokinetic parameters compared to normal controlled subjects.

After taking a single dose of 7.5 mg/kg or 20 mg/kg for patients to cut tonsils, the drug concentration in tonsils 1-4 hours after use is in the range of 0.4 - 4 µg/g. This concentration is at least 25 times higher than the concentration of inhibitors (MIC) for Streptococcus Pyogenes.

Creatinine clearance 30 ml/120 minutes and treatment time like normal people.

Be cautious when using

Before starting treatment with Cefprozil, it is advisable to check the previous allergic reactions with Cefprozil, Cephalosporin, Penicillin and other drugs, because the cross-reaction between β-lactam antibiotics has been proven in about 10% of patients with a history of allergy to penicillin. If allergic reactions occur with Cefprozil, the medication should occur. Hypersensitive or severe hypersensitivity reactions if encountered, need to apply emergency measures.

Antibiotic treatment can alter normal bacteria strains in the intestine and overgrowth in resistance bacteria, such as Clostridium difficile, which is the main cause of fake colitis, can be from mild to life -threatening.

Patients should be appropriate treatment if diagnosed with fake colitis. Mild cases just stop the drug, the disease may end.

For patients with or suspected kidney failure, clinical monitoring must be monitored and conducted subclinical tests suitable before and after treatment. Reduce Cefprozil's daily daily dose with these cases. Caution should be careful when indicating cephalosporins, including cefprozil, for patients who are taking diuretics due to kidney function.

Be careful when indicating Cefprozil for patients with a history of intestinal disease, especially colitis.

The positive reaction to the direct Coombs test has been reported when using cephalosporin antibiotics.

The impact of the drug on the driver and operating machinery

Patients may get dizzy when taking the drug. Therefore, it is necessary to warn the patient about this side effect if they drive or operate the machine when treated with Cefprozil.

Pregnancy

The toxic test on the fetus in the mouse, the rabbit using Cefprozil oral oral doses of 0.8: 8.5 and 18.5 times in the maximum of people who do not record harmful to the fetus. However, due to no human evidence, the use of drugs for women during pregnancy is only needed.

The period of breastfeeding

A small amount of drug (less than 0.3% of the dose) was found in breast milk when the mother took the drug at a single dose of 1 gram. The average drug concentration for 24 hours is from 0.25 to 3.3 g/ml. Be careful when taking the drug because the effect of the drug on the infant unknown.

Drug interaction

Kidney toxicity has been reported when concurrently used aminoglycosides and cephalosporin simultaneously.

Probenecid doubles Cefprozil's AUC when used, and the bioavailability of Cefprozil is not affected when taking after an antacid drug 5 minutes.

Cephalosporin antibiotics cause false positive phenomenon in urine testing with Fehling reagent or basify, which affects the test results of enzymes like clinistix. The false negative reaction can occur with Ferricyanide test to check blood sugar.

cefprozil does not affect the quantification of creatinine in the blood or urine by alkaline picrat.