Bromhexin 8mg medicine 3-2 dissolves in bronchitis, chronic bronchitis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Bromhexine
Ingredient Coughing with phlegm, pulmonary, acute bronchitis, bronchiectasis, chronic obstructive pulmonary, chronic bronchitis

Ingredient

Composition information	Content
Bromhexine	8mg

Uses

Indications

Bromhexin drugs are indicated in the following cases: bronchial disorders, especially in acute bronchitis, acute batch of chronic bronchitis.

Pharmacokic

Bromhexin hydrochloride is a regulating and respiratory mucus. Due to the activation of sialomucin synthesis and breaking the acid mucopolysaccharid fibers, the drug makes the sputum more liquid and less. The drug makes phlegm easier, so the sputum should be exhausted effectively.

When drinking, it usually takes 2-3 days to show clinical effects.

pharmacokinetics

Bromhexin hydrochloride quickly absorbed through the gastrointestinal tract and is initially metabolized in the liver very strong, so bioavailability only reaches 20-25%. Food increases the bioavailability of Bromhexin hydrochloride. Peak concentration in plasma, in healthy volunteers, achieved after drinking, from half an hour to 1 hour.

Bromhexin hydrochloride is widely distributed into the body's tissues. The drug is very strong (over 95%) with plasma protein.

Bromhexin is metabolized mainly in the liver. There has been a detection of at least 10 metabolites in plasma, in which, ambroxol is a metabolite that is still active. Half of the lifetime elimination of the drug in the last phase is 12 - 30 hours depending on the individual, because in the first phase, the drug is much distributed into the body's tissues. Bromhexin passes through the brain barrier, and a small amount passes the placenta in the fetus.

About 85 - 90% of the dose is deducted from urine, mainly in the form of metabolites, after being associated with sulfuric acid or glycuronic acid and a small amount is excreted. Bromhexin is excreted in very little fertilizer, only about 4%.

Before taking Bromhexin 8mg medicine 3-2 dissolves in bronchitis, chronic bronchitis (3 blisters x 10 tablets)

How to use

Bromhexin oral use.

Dosage

Adults and children over 12 years old

Take 8 - 16mg x 3 times/day.

Take each ½ tablet (4mg), 3 times a day.

The treatment time must not exceed 5 days without medical advice. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? If an overdose occurs, symptomatic treatment and support.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using bromhexin, you may experience unwanted effects (ADR).

Rarely cases such as digestive disorders, skin allergies.

Can worsen the phlegm in the bronchus in some patients who cannot spare themselves.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Bromhexin drugs are contraindicated in the following cases:

Patients sensitive to bromhexin or other ingredients of the drug.

First 3 months of pregnancy and nursing women.

Precautions when using

cases of serious skin reactions rare such as diverse roses, Stevens-Johnson syndrome/indigestion and external pustular syndrome (AGEP) when using bromhexin has been reported. If there are signs or symptoms of progressive leather rash (sometimes combined with a blent's or mucosal lesions), you should stop the drug immediately and consult your doctor.

Bromhexin precipitates in a solution with pH> 6.

Do not dissolve the drug in these solutions.

Do not use a combination of mucus with mucus. While using bromhexin, it is necessary to avoid coordinating with cough drugs because of the risk of stagnation in the respiratory tract.

bromhexin, due to the effect of eliminating mucus, can cause damage to the stomach mucosa, so when used for patients with a history of stomach ulcer must be very cautious.

Be careful when used for asthma patients, because bromhexin can cause bronchospasm in some sensitive people.

Bromhexin clearance and metabolic substances can be reduced in patients with severe liver or kidney failure, so it is necessary to be cautious and monitor.

Be cautious when using bromhexin for the elderly or severe weakness, children because they are not able to sputum effectively, thus increasing phlegm.

Note: The ingredient contains Lactose excipients so patients with rare genetic disorders in galactone tolerance, Lapp lactase deficiency or glucose-galactose absorption disorders should not use this drug.

The ability to drive and operate machinery

Need to be cautious when driving and operating machinery if there are side effects such as headache, dizziness.

Pregnancy

Not used for women who are pregnant in the first 3 months and nursing women.

Breastfeeding period

Do not use for pregnant women in the first 3 months and nursing women.

Drug interaction

do not coordinate with drugs to reduce discharge (reducing bronchial secretion) such as Atropin -style drugs (or anticholinergic) because of the effect of bromhexin.

Do not coordinate with anti -cough drugs.

Use bromhexin combination with antibiotics (amoxicillin, cefuroxim, erythromycin, Doxycyclin) that increases antibiotic concentration into lung and bronchial tissue. Thus, bromhexin can act as a supplement in the treatment of respiratory infections, increasing the effects of antibiotics.

Storage

Leave in a dry place, temperatures below 30 ° C, avoid light.

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