Bronast 20mg Aristopharma medicine for gastroesophageal reflux treatment (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Esomeprazole
Ingredient Peptic ulcer, gastroesophageal reflux

Ingredient

Composition informationContent
Esomeprazole20mg

Uses

indications

Bronast Tablet is indicated in the following cases:

adolescents over 12 years old

Gastroesophageal reflux disease (GERD)

  • Treatment of esophageal ulcer due to reflux.
  • Prevention of esophagitis recurrence.
  • Symptomatic treatment of gastroesophageal reflux disease.
  • combined with antibiotics in eradicating Helicobacter pylori.

    • Adults

    Gastroesophageal reflux disease (GERD)

  • Treatment of esophageal ulcer due to reflux.
  • Prevention of esophagitis recurrence.
  • Symptomatic treatment of gastroesophageal reflux disease.

    • Combined with antibiotics in eliminating Helicobacter pylori

  • Heals gastric and duodenal ulcers caused by Helicobacter pylori.
  • Prevention of recurrence of stomach ulcers in patients infected with Helicobacter pylori.

    • In patients who are taking NSAID

  • Prevention of ulcers in patients who are using NSAID or patients at risk.

    • Zollinger - Ellison syndrome and other cases are accompanied by increased stomach acid secretion.

  • Prolonged treatment after treatment for hemorrhage due to intravenous peptic ulcer.

    • Pharmacology

    No information.

    pharmacokinetics

    There is no information.

    Before taking Bronast 20mg Aristopharma medicine for gastroesophageal reflux treatment (6 blisters x 10 tablets)

    How to use

    Take medicine at any time of the day.

    Can be taken before or after eating.

    Swallow the tablet with water, do not chew or crush before drinking.

    Dosage

    Adults and children over 12 years old

    Gastroesophageal reflux disease

  • Treatment of esophageal ulcer due to reflux: 40 mg daily for 4 weeks. Can be used for 4 more weeks for patients who still have inflammation.
  • Prevention of esophagitis recurrence: 20 mg daily.
  • Symptomatic treatment of gastroesophageal reflux disease: 20 mg per day if the patient does not have esophagitis due to reflux about 4 weeks.
  • Combined with antibiotics in eliminating Helicobacter pylori: 20 mg Esomeprazol combined with 1 g amoxicillin and 500 mg Clarithromycin, 2 times a day within 7 days.

    • In patients who are taking NSAID

  • Treatment of stomach ulcers due to the use of anti -inflammatory drugs NSAID: 20 mg daily for 4 - 8 weeks.
  • Preventive gastric ulcer prevention in people with high risk of stomach - duodenal complications, but required to continue treatment with nonsteroidal anti -inflammatory drugs: Take 20 mg daily.

    • Treatment of Zollinger Ellison syndrome

    recommended starting dose is Esomeprazol 40 mg, twice a day. Then adjust according to the response of each patient and continue treatment when clinical indications.

    People with kidney function damage

    No need to adjust the dose in patients with renal function damage. Due to less experience in using drugs in patients.

    Liver function damage

    No need to reduce the dose in people with liver function damage is mild to moderate. In patients with severe liver failure, maximum overdose should not be used for 20 mg Esomeprazol.

    Elderly

    No dose adjustment in the elderly.

    Children under 12 years old

    There is no research data when using Esomeprazol for children under 12 years old.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

    do when overdose? asleep; blurred vision; tachycardia; nausea; sweating; hot burning; headache; Dry mouth.

    When there is an abnormal manifestation due to overdose of the drug, please contact the doctor or the nearest medical facility immediately for timely treatment.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

    Side Effects

    When using Bronast Tablet, you may experience unwanted effects (ADR).

    Common, ADR> 1/100

  • Nervous system disorders: headache.
    • digestive disorders: abdominal pain, constipation, diarrhea, bloating, nausea/vomiting.

    Uncommon, 1/1000

  • Metabolic and nutrient disorders: peripheral edema.

    • Mental disorders: Insomnia.

  • Nervous system disorders: dizziness, paresthesia, chicken sleep.

    • Digestive disorders: dry mouth.

    Liver disorders: Hyper enzyme.

    Skin and tissue disorders: Dermatitis, itching, rash, urticaria.

    musculoskeletal and connective tissue disorders: hip fractures, wrists and spine.

    Rare, ADR

  • Blood disorders and lymphatic systems: leukopenia, thrombocytopenia.

    • Immune system disorders: Hypersensitivity reactions such as fever, angioedema, anaphylactic/anaphylactic reaction.

  • Disorders of metabolism and nutrition: Hemati sodium.

    • Mental disorders: agitation, confusion, depression.

    Nervous system disorders: taste disorders.

    eye disorders: blurred vision.

  • Disorders of ears and mesmerizing: Dizziness.
  • Respiratory, chest and mediastinum disorders: bronchial spasm.

    • Gastrointestinal disorders: stomatitis, gastrointestinal candidiasis.

    Hepatitis: Hepatitis has or no jaundice.

    Skin and subcutaneous tissue disorders: baldness, light sensitivity.

  • musculoskeletal and connective tissue disorders: joint pain, muscle pain.
  • Kidney and urinary disorders: interstitial nephritis; In some patients with the accompanying renal failure, it has been reported.
  • General and on -site disorders: difficult to live, increase sweating.

    • Very rare

  • Blood disorders and lymphatic systems: leukocyte loss, reducing all blood cells.
  • Metabolic and nutrient disorders: Hemiasor reduces, severe blood magnesium may be associated with reducing blood calcium. Lose magnesia blood can also lead to hypokalemia.

    • Liver disorders: Hepatic failure, brain disease in patients with liver disease.

    Mental disorders: impatient, hallucinations.

  • Skin and tissue disorders: Diverse roses, Stevens - Johnson syndrome, toxic epidermal necrosis (ten).
  • Musculoskeletal and connective tissue disorders: muscle weakness.
  • Reproductive and mammary disorders: Female mammary glands.

    • Unknown frequency

  • Gastrointestinal disorders: microscopic colitis.

    • Instructions for processing ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    contraindicated

    Bronast Tablet drugs contraindicated in the following cases:

  • Hypersensitivity to Esomeprazole, Benzimidazoles group or any ingredient of the drug.
  • Do not use Esomeprazol simultaneously with Nelfinavir, Atazanavir.

    • Be cautious when using

    when there is any alarm symptom (such as significant weight loss, recurrent vomiting, difficulty swallowing, vomiting blood or black stools) and suspicion or stomach ulcers should eliminate malignant diseases because Esomeprazol treatment can reduce symptoms and delay diagnostic.

    Patients with long -term treatment (especially in people who treat more than 1 year) should be monitored regularly.

    Patients treated according to the regime when necessary should contact the doctor if there are symptoms that change in characteristics. When prescribing Esomeprazol according to the treatment regime when necessary, it is advisable to consider the interaction associated with other drugs due to the change in the plasma Esomeprazol level.

    Patients with rare genetic problems such as fructose intolerance, glucose - galactose or deficiency - isomaltase should not be used esomeprazol.

    Proton pump inhibitors may increase the risk of gastrointestinal infections from Salmonella and Campylobacter.

    It is not recommended to simultaneously use Esomeprazol with Atazanavir. If the combination of Atazanavir with proton pump inhibitors is inevitable, closely monitoring.

    Esomeprazol can reduce vitamin B12 absorption. Therefore, it is necessary to consider when using drugs in people with reduced vitamin B12 reserves or risk factors for reducing vitamin B12 absorption when long -term treatment.

    Do not encourage simultaneous use of esomeprazol and clopidogrel.

    Patients with osteoporosis should be taken care of under the current clinical instructions and should be added with an appropriate amount of vitamin D and calcium.

    The ability to drive and operate machinery

    Esomeprazol does not affect the ability to drive and operate machinery.

    Pregnancy

    does not have enough clinical data on the use of esomeprazol in pregnant women. Should be cautious when using drugs for pregnant women.

    The period of breastfeeding

    It is unknown whether esomeprazol is excreted through breast milk or not. Therefore, you should not use esomeprazol during breastfeeding.

    Drug interaction

    Esomeprazol's impact on pharmacokinetics of other drugs

    For pH -dependent absorption drugs: It is not recommended to use Esomeprazol simultaneously with Atazanavir and contraindicated using Esomeprazol simultaneously with Nelfinavir.

    Metabolic drugs simultaneously with nelfinavir.

    CYP2C19 metabolic drugs

    Monitor patients at the beginning and when the treatment is simultaneously, Esomeprazol with Warfarin or other Coumarin derivatives because the drug can cause significant increase in Inr clinically.

    Esomeprazol has no significant clinical impact on pharmacokinetics of amoxicillin, quinidine.

    has not identified any clinical pharmacokinetic interactions when used simultaneously Esomeprazol with Naproxen.

    Do not encourage simultaneous use of esomeprazol and clopidogrel.

    Esomeprazol increases serum concentration of tacrolimus.

    Methotrexate levels may increase when used simultaneously with PPI. So when using high doses of methotrexate, it is advisable to temporarily pause Esomeprazol.

    Effect of other drugs on pharmacokinetics of Esomeprazole

    Esomeprazol is metabolized by CYP2C19 and CYP3A4. CYP2C19 and CYP3A4 may cause a decrease in serum Esomeprazole due to Esomeprazole metabolism.

    Storage

    Put the medicine in a dry place, avoid direct contact with the sun, under 30 ° C.

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