Broso Brosuvon 4mg Binh Thuan thin sputum in acute and chronic bronchitis (20 packs x 15ml)

Dosage form Syrup
Specifications Box of 20 packs x 5ml
Ingredient Bromhexin hydrochloride

Ingredient

Thành phần cho 5ml

Composition information	Content
Bromhexin hydrochloride	4mg

Uses

indications

Brosuvon medicine helps dilute phlegm in acute and chronic bronchial diseases with abnormal mucus secretion and weakened mucus.

Pharmacokic

bromhexin is a synthetic derivative from the active ingredient Vasicine.

Clinically, bromhexin is noticed that increases the ratio of bronchodilatoma.

Bromhexin increases the transportation of mucus by reducing the slightness of mucus and active epithelial activity with velvet (total mucus with hair transfer).

In clinical trials, bromhexin shows the effect of diluting the secretion and transporting secretions in the bronchial sugar to facilitate the sputum and they are easy.

After treatment with bromhexin, antibiotic concentration (amoxicillin, erythromycin, oxytetracyclin) in phlegm and bronchial secretions increase.

pharmacokinetics

absorption:

Bromhexin absorbs quickly and completely through the gastrointestinal tract.

Birth is equivalent after taking solid form and solution.

Absolute bioavailability of Hydroclorid bromhexin is about 22.2 ± 8.5 % and 26.8 ± 13.1 % corresponding to the solution of Brosuvon solution.

The first amount of metabolites is about 75 - 80 %.

Use the same food leads to increased bromhexin levels in plasma.

Distribution:

After using intravenous lines, bromhexin is distributed quickly and widely throughout the body with average distribution (VSS) up to 1209 Brosuvon 206 L (19 l/kg). Has studied the distribution into the lung tissue (bronchial and parenchyma) after taking 32 mg and 64 mg of bromhexin. The concentration of lung tissue after 2 hours of drug use, concentration at bronchial - bronchial tissue is 1.5 - 4.5 times higher and in pulmonary parenchyma is about 2.4 - 5.9 times higher than plasma concentrations.

Bromhexin binding in a constant form with plasma proteins is about 95 % (unlimited link).

Metabolism:

Bromhexin metabolizes almost completely into diverse hydroxy metabolites and into dibromanthanilic acid. All metabolites and bromhexin themselves are combined in the form of n-glucuronide and o-glucuronide. There is no significant evidence of changing the metabolic method due to sulphonamid, oxytetracycline or erythromycin. Therefore, the corresponding interaction is due to the CYP 450 2C9 and 3A4 substrate.

Era:

After using intravenous sugar, bromhexin has a high rate of extract within the range of blood flow through the liver, 843 - 1073 ml/minute, resulting in a large difference between individuals and on the same individual (CV> 30 %). After using bromhexin with radioactive marking, about 97.4 % ± 1.9 % of the dose found in the form of radioactive in the urine, with the original active ingredient below 1 %. Plasma bromhexin concentration decreases with exponential expansion. After taking single -dose from 8 to 32 mg, the last half -life is in the range of 6.6 - 31.4 hours. Half -life elimination related to predictions in multi -dose learning is about 1 hour, so there is no accumulation after multi -dose use (accumulation coefficient 1.1).

General:

Bromhexin represents pharmacokinetics proportional to the dose within 8 to 32 mg after oral use.

There is no bromhexin pharmacokinetic data on elderly patients or patients with liver or renal failure. Clinical experience does not show problems related to safety on these subjects. There are also no studies on interactive with oral anticoagulants or digoxin. The pharmacokinetics of bromhexin are not affected relevant when using ampicillin or oxytetracyclin simultaneously. The previous comparison did not see the corresponding interaction between bromhexin and erythromycin.

There is no related interaction report for a long time for drug circulation to suggest negligible interaction with these drugs.

Before taking Broso Brosuvon 4mg Binh Thuan thin sputum in acute and chronic bronchitis (20 packs x 15ml)

How to use

Brosuvon pills form syrup.

Dosage

recommended dose:

Adults and children over 12 years old: 10 ml (8 mg), 3 times daily. The daily dose must be increased daily to 48 mg (60 ml or 20 ml 3 times daily) in adults and children over 12 years old.

In the indication of acute respiratory disease, based on each patient to decide whether the doctor's opinion depends on the symptoms that improve or worsen during treatment.

Brosovon Siro treatment time does not exceed 8 - 10 days without consulting the doctor.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Based on the overdose reports and/or the use of the wrong drug, the observation symptoms are suitable for the known side effects of Brosuvon at the recommended dose and may need symptom treatment.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using the drug, there are common unwanted effects (ADR) such as:

immune system disorders

Rare (≥ 1/10,000 to Unknown (not estimated from available data): bronchospasm.

Not common (1/1,000 to Rare (≥ 1/10,000

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Brosuvon drugs contraindicated in the following cases:

Do not use Brosuvon syrup for patients who know how to be hypersensitivity to bromhexin or other ingredients of the drug.

Be cautious when taking drugs

There are very few serious skin damage reports such as Stevens - Johnson syndrome and toxic epidemic epidermal necrosis (Ten) temporarily related to the use of sputum as bromhexin.

Most cases are explained by the disease that the patient is suffering from and/or medication. Moreover, in the early stages of Stevens - Johnson or Ten, the patient first has no specific influenza symptoms such as fever, human aches, rhinitis, cough and sore throat. Due to being mistaken for these non -specific influenza symptoms, one can start treating symptoms of cough and colds. Therefore, if a few new lesions appear on the skin or mucosa, you should see a doctor immediately and stop treatment with bromhexin.

Be cautious when using Brosuvon Siro simultaneously and inhibitors to avoid accumulating secretions due to cough decline and this combination should only be used after benefits - risk assessment.

Use cautiously in patients with stomach ulcers.

Use cautiously in patients with bromhexin micro asthma can cause bronchospasm in some sensitive people.

Must be very cautious when using Brosuvon syrup in patients with severe kidney or liver failure.

In patients with severe renal impairment, accumulating the metabolites of bromhexin formed in the liver may occur.

Caution used in patients is elderly, weak or too weak without sputum.

Sorbitol drug alert: Patients with non -intolerance with genetic fructose should not use this drug.

Sodium benzoate alert: may increase the risk of jaundice in newborns.

Warning of Saccharin: In the case of diabetes patients should be cautious.

Using drugs for women during pregnancy and lactation

Cases of pregnant women:

Data using bromhexin for pregnant women is limited.

Animal studies do not show direct or indirect harmful effects related to reproductive toxicity.

Should be cautious by avoiding using Brosuvon during pregnancy.

Cases of breastfeeding women:

It is unclear whether bromhexin/metabolites will be excreted into the mother's milk.

Data available for pharmacological/animal toxicity shows the excretion of bromhexin/metabolites into breast milk.

cannot rule out the risk for breastfeeding.

Do not use Brosuvon syrup during breastfeeding.

The effect of the drug on driving and operating machinery

has not studied the effect of Siro Brosuvon on the ability to drive and operate machinery.

Drug interaction

has not seen a report on adverse interactions with other clinical drugs.

Be cautious when using Brosuvon Siro and the inhibitors to avoid accumulating secretions due to cough reduction and this combination should only be used after evaluation of benefits - risks.

Avoid using bromhexin with drugs that reduce secretion like atropine -style drugs.

Using bromhexin combination with antibiotics increases antibiotic concentration into lung and bronchial tissue; Therefore, the drug is used in combination with antibiotics in the treatment of respiratory tract infections.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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