Brucipro tablets 500mg treatment of severe infections (10 blisters x 10 tablets)

microbiology

ciprofloxacin has strong activity, broad spectrum antibacterial. It blocks information from chromosomes (genetic material) necessary for normal metabolism of bacteria. This causes bacteria to reduce fertility quickly.

Due to this specific acting mechanism, Ciprofloxacin is not resistant to other antibiotics not in the Gynase inhibitor group. Ciprofloxacin is highly effective against antibiotic -resistant bacteria such as aminoglycosides, penicilin, cephalosporin, tetracycline and other antibiotics.

antibacterial spectrum

The following bacteria are considered sensitive:

Escherichia Coli, Shigella, Salmonella, Citrobacter, Klebsiella, Entobacter, Serratia, Hafnia, Edwardsiell, Proteus, Provida, Morganella, Yersinia, Vibrio, Aeromonas, Plesiomonas, Pasteurella, Haemophilus, Campylobyl, Pseudomonas, Legionella, Neisseria, Moraxella, Staphylococcus, Listeria, Corynebacterium, Chlamydia.

The following bacteria have different sensitivity levels:

Gardnerella, Flavobacterium, Alcaligenes, Streptococcus Agalactiae, Streptococcus Faecalis, Streptococcus Pyogenes, Streptococcus Pneumomae, Streptococcus Viridans, Mycoplasma Hominis, Mycobacterium tuberculosis and mycobacterium and mycobacterium Fortuitum.

The following bacteria are often resistant:

Enterococcus Faecium, UuseaPlasma Urealyticum, Nocardia Asteroides. Anaerobic bacteria have a moderate sensitivity (peptococcus, peptostreptoccus) to resistance. Ciprofloxacin does not have the anti -Treponema pallidium effect.

pharmacokinetics

ciprofloxacin absorbs quickly and easily in the digestive tract. When food and anti -acid drugs, the absorption of drugs is slower but not significantly affected. After drinking, the maximum concentration of Ciprofloxacin in the blood appears after 1-2 hours with absolute biological available 70% - 80%.

Half of life in plasma is about 3.5 hours to 4.5 hours in patients with normal kidney function, this time is longer in patients with kidney failure and in the elderly.

The distribution of ciprofloxacin is very large (2-3 liters/kg body weight) and therefore, dialysis or abdominal separation only draws a small amount of medicine. The drug is widely distributed and has high concentrations in infected places.

about 40 - 50% of oral dose is eliminated in the form of unchanged urine by filtering in the glomerular filter and excreted in the renal tubules. Other elimination lines are metabolic in the liver, excreted bile, and excreted through the mucosa into the intestine. The drug is excreted within 24 hours.

Instructions on how to handle ADR:

To avoid the crystal, maintain enough drinking water, avoid making the urine too alkaline.

If the diarrhea is severe and prolonged during and after treatment, the patient may have suffered from severe disorders in the intestine (fake colitis). Ciprofloxacin should be stopped and replaced with another appropriate antibiotic (eg vancomycin).

If there is any sign of side effects, it is necessary to stop using ciprofloxacin and patients need to be treated at a medical facility, although these side effects are usually mild or moderate and will stop when stopping ciprofloxacin.

Notify the doctor with unwanted effects when taking the drug.

The effect of the drug on the ability to drive and operate machinery

because the drug can cause some unwanted effects such as dizziness, trembling, hallucinations ..., should be cautious when driving and operating machinery.

Using drugs for women during pregnancy and lactation

Using drugs for pregnant women:

Should only use Ciprofloxacin for pregnant women in severe bacterial infections without other antibiotics instead, forced to use fluoroquinolon.

Use medicine for breastfeeding women:

Do not use ciprofloxacin for nursing mothers, because ciprofloxacin accumulates in milk and can reach the concentration that can cause harm to children. If the mother is forced to use ciprofloxacin, they must stop breastfeeding.

Medicinal interactions

Concentrated nonsteroidal anti -inflammatory drugs (ibuprofen, indomethacin ...) will increase the side effects of ciprofloxacin.

Concomitance anti -acid drugs with aluminum and magnesi will reduce serum levels and reduce bioavailability of ciprofloxacin. Do not take Ciprofloxacin at the same time with anti -acid drugs, need to take the medicine apart (should take anti -acid drugs 2 - 4 hours before taking Ciprofloxacin), though this way does not solve the problem thoroughly.

Ciprofloxacin absorption may be reduced half if used simultaneously some cyclophosphamide, vincistin, doxorubicin, cytosin arabinosid, mitozantron).

If using the Convidinosin simultaneously, the concentration of ciprofloxacin is significantly reduced. Ciprofloxacin should be taken before using Didanosin for 2 hours or after using Didanosin 6 hours.

iron preparations (Fumarat, Gluconate, Sulfate) significantly reduce the absorption of ciprofloxacin in the intestine.

Zinc preparations have less effects. Avoid simultaneous use of ciprofloxacin with iron or zinc -oriented preparations or take these drugs as far as possible.

Take the sucralfate at the same time will reduce the absorption of ciprofloxacin significantly. Antibiotics should be given 2 - 6 hours before taking sucralfat.

Take Ciprofloxacin simultaneously with theophylin may increase the concentration of theophylin in serum, causing the side effects of theophylin. The chest of theophylin concentration in the blood, and may be reduced by theophylin if it is forced to take 2 drugs.

ciprofloxacin and ciclosporin use simultaneously can cause temporary increased serum creatinine. Should check blood creatinine twice a week.

Probenecid reduces glomerular filtration level and reduces the excretion in the renal tubules, thus reducing the elimination of drugs through urine.

warfarin in combination with ciprofloxacin can cause prothrombin. Need to regularly check blood prothrombin and adjust the dose of anticoagulants.