Bterol 150mg Atlantic medicine for primary hypertension (2 blisters x 14 tablets)

Dosage form Box of 2 blisters x 14 tablets
Specifications Irbesartan
Ingredient Chronic renal failure, high blood pressure

Ingredient

Composition information	Content
Irbesartan	150mg

Uses

indications

Bterol drugs are indicated in the following cases:

primary hypertension. The AT1 receptor blocker of Angiotensin II helps prevent the entire effect of Angiotensin II through the AT1 receptor intermediaries regardless of the origin or synthesis of Angiotensin II. The selective inhibition of Angiotensin II receptor (AT1) increases the level of resin and angiotensin II in the blood and reduces the concentration of aldosteron in the blood.

Serum growth is not affected by the recommended dose of Irbesartan, unless kidney failure and/or heart failure. Irbesartan does not inhibit the enzyme (Kinase II), an enzyme that produces antiotensin II and is an enzyme that affects Bradykinin's desperation into inactive metabolites. Irbesartan does not have to be converted into metabolites for this effect.

Hypotension effect depends on the dose and tends to not lower when taking a dose higher than 300 mg/day. If the blood pressure is stopped, there is no sudden serious illness when stopping the drug. Anti -blood pressure effects of Irbesartan and thiazid diuretics are combined.

Dynamic pharmacokinetics

fast absorption through the gastrointestinal tract with bioavailability of 60 - 80%. Food does not change much of the bioavailability of the drug.

The drug is partially metabolized in the liver to form non -active products. The peak concentration of plasma is about 1-2 hours after a dose of oral. The concentration of medication in the blood reaches a stable equilibrium after 3 days of taking medicine.

Irbesartan binds to 96% plasma proteins. The distribution of the drug is about 53 - 93 liters. Eliminating drugs through bile and urine. After drinking, about 20% of the drug excreted through metabolic urine and less than 2% in non -metabolic form. Half of the selling lifetime is 11 - 15 hours.

Before taking Bterol 150mg Atlantic medicine for primary hypertension (2 blisters x 14 tablets)

How to use

oral medication.

Dosage

Adults

The usual dose starts and maintains is 150 mg/time/day. Can be taken in, before or after meals.

The dose of 150 mg/day/day allows blood pressure control for 24 hours better than the dose of 75 mg. However, the dose of 75 mg/day/day is indicated for patients to dialysis or people over 75 years old.

If the dose of 150 mg/day is not enough to control blood pressure, the dose can be increased to 300 mg/day. Or use another anti -hypertension drug, like Irbesartan combined with a diuretics such as hydrochlorothiazide will bring about combined blood pressure.

Kidney disease in patients with type 2 diabetes with hypertension

The starting dose is 150 mg/time/day. Adjust up to 300 mg/day as a maintenance dose.

kidney failure

No dose adjustment in people with renal impairment. For patients who have to dialysis, the starting dose of 75 mg/day.

Hepatic failure

No dose adjustment in patients with mild and medium liver failure. There is no clinical experience for people with severe liver failure.

Children

has not determined the safety and effectiveness of Irbesartan in children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? In case of overdose, clinical symptoms are likely to occur as hypotension and tachycardia. The slow rhythm can also occur.

There is no specific therapy during the Irbesartan overdose treatment. Patients should be strictly monitored, symptomatic treatment and power. Some can be applied such as vomiting, and/or gastric lavage, using activated carbon. Irbesartan cannot be removed by dialysis.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Bterol, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Dizziness, headache, hypotension stands related to the dose.

Lagging blood pressure may occur, especially in patients with hypoglycemia. Kidney failure and severe blood pressure loss when narrowed kidney narrowing on both sides.

Uncommon, 1/1000

Skin rash, urticaria, itching, angioedema, liver enzyme. Hyperbonia, muscle pain, joint pain.

Rare, ADR

cough, respiratory disorders, back pain, digestive disorders, fatigue, neutropenia

Instructions on how to handle ADR

Notify the doctor any unwanted effects encountered during the use of the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Bterol drugs contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug.

Pregnant and lactating women.

Caution when using

reducing blood volume

In patients with hypoglycemia such as salt loss and water due to strong diuretics, diarrhea or vomiting, it is necessary to treat blood volume before Irbesartan.

Renal artery stenosis

Patients with kidney stenosis when using Irbesartan are at risk of severe hypotension and impaired renal function.

kidney transplant or kidney failure

Need to be cautious with these patients. Checking the concentration of potassium and blood creatinine is necessary.

High blood potassium

may experience hyperkalemia when using Irbesartan, especially in patients with heart and kidney function. For people, should regularly check potassium. Avoid simultaneous use of Irbesartan with potassium diuretics.

Cuong Aldosteron Tien Phat

Patients with primary Aldosteron intense often do not respond to antihypertensive drugs effectively acting through inhibition of the renin-angiotesin system. Therefore, Irbesartan does not work on these patients.

As well as other vasodilators, Irbesartan must be used carefully in diseases such as aortic valve stenosis and mitral valve stenosis, obstructive hypertrophic heart disease.

In general, Irbesartan must be cautious for patients with vascular energy and renal function depends mainly on the activity of the renin-angiotensin-aldosteron system: The risk of strong, sudden hypotension is easy to cause muscle infarction or stroke.

Because the drug contains lactose, people with galactose tolerance, lactase enzyme deficiency or do not absorb glucose-galactose should not use the drug.

The ability to drive and operate machinery

When driving and operating machinery, pay attention carefully because the drug causes dizziness. Occasionally may occur fatigue during the treatment of hypertension.

Pregnancy

Contraindicated drugs for pregnant women. In the first 3 months of pregnancy, contraindicated due to caution. In the 3 months or the last 3 months of pregnancy can directly affect the Rennin-Anotensin system, causing kidney failure in the fetus or babies, deformed face, even causing fetal death.

When detected pregnancy, stop the drug as soon as possible. If the drug has been used for a long time, it is necessary to check the skull and kidney function with the sound of the fetus.

Breastfeeding period

Contraindications for use for breastfeeding women.

Interactive drug

with other anti -hypertension drugs

Other anti -hypertension drugs may increase the hypotension effect of Irbesartan. However, Irbesartan can still be combined with other anti -hypertension drugs such as beta blockers, calcium blockers or thiazid diuretics. An advance treatment with high doses can create a decrease in blood volume and the risk of hypotension when taking Irbesartan.

Potassium supplements or potassium diuretics

Concomitance Irbesartan with diuretics holding potassium or potassium supplements can increase potassium levels.

lithium

Increased serum and recovery lithium concentration has been reported when combined with enzyme inhibitors. Because the drug interaction has not been determined with Irbesartan and has not been eliminated, it is still necessary to closely monitor serum lithium concentration.

Storage

Store in a cool dry place, below 30 ° C, avoid light.

Other drugs

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