Buscopan medicine 10mg Sanofi reduces genital - urinary smooth spasms (5 blisters x 20 tablets)

Dosage form Tablet
Specifications Box of 5 blisters x 20 tablets
Ingredient Hyoscin Butylbromid

Ingredient

Composition information	Content
Hyoscin Butylbromid	10mg

Uses

indications

Buscopan 10 drugs are indicated in the following cases:

Reduce genital - urinary or digestive muscle spasms. Treatment of irritable bowel syndrome. ATC code: A03BB01.

Buscopan shows anti -spasms on the smooth, biliary tract and sexual tract. As a quadratic ammonium derivative, Hyoscin Butylbromid does not enter the central nervous system. Therefore, the side effect of cholinergic resistance on the central nervous system does not appear.

Peripheral anti -cholinergic resistance is the result of inhibition of lymphadenopathy within organs as well as Muscarinic resistance.

Dynamic pharmacokinetics

absorption

As a level 4 ammonium compound, Hyoscin Butylbromid is strong and thus absorbs only a part after oral use (8%) or rectal line (3%). After taking the single dose from 20 mg - 400 mg hyoscin butylbromid, the peak concentration in plasma is about 0.11 ng/ml - 2.04 ng/ml achieved after about 2 hours. With the same dose, AUC0 -Tz value is from 0.37 - 10.7 ng. The median of absolute use of various forms such as bags, bullets, oral solution containing 100 mg of hyascin butylbromid is below 1%.

distribution

Due to high affinity with Muscarinic and Nicotinic receptors, Hyoscin Butylbromid is mainly distributed in the smooth muscles of the abdomen and pelvis as well as lymph nodes in the abdominal organs. Hyoscin Butylbromid's plasma protein (albumin) is about 4.4%. Animal studies have shown that Hyoscin Butylbromid does not pass the blood -brain barrier, but there is no clinical data available for this effect. In vitro, Hyoscinda Butylbromid (1 mm) is recorded as an interaction with the transportation of Choline (1.4 nm) in the epithelial cells of human placenta.

transformation and elimination

After orally oral, single dose in the dose of 100 mg - 400 mg, the last half -life is 6.2 to 10.6 hours. The metabolic line is the ester hydrolysis. Hyoscin Butylbromid is used to be eliminated through feces and urine. Human studies show that 2-5% of the radioactive dose is eliminated by the kidneys after oral use and 0.7 - 1.6% after rectal use. About 90% of radioactive substances are rediscovered in stool after oral use. Excretion in urine of Hyoscin Butylbromid is below 0.1 % of the dose. After oral doses of 100 to 400 mg, the average apparent clearance is between 881 to 1420 l/min, while the corresponding distribution volume of the same dose ranges from 6.13 to 11.3 x 105 l is likely due to the very low total available.

Before taking Buscopan medicine 10mg Sanofi reduces genital - urinary smooth spasms (5 blisters x 20 tablets)

How to use

only use 10 mg of Buscopan tablets. Should swallow the whole Buscopan tablet 10 mg with enough water.

Dosage

Adults: 2 capsules 4 times/day. For treatment of irritable bowel syndrome, the recommended starting dose is 1 tablet x 3 times/day. Can increase the dose to 2 capsules 4 times/day if necessary.

Children from 6 - 12 years old: 1 tablet x 3 times/day.

There is no specific information about drug use and for the elderly. Clinical trials include patients over 65 years old and not record any typical side effects on this group of patients.

Do not use Buscopan 10 mg daily or prolonged when abdominal pain without searching for the cause.

Not for children under 6 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

symptoms

Not recorded signs of serious poisoning in people in case of acute overdose. In the case of overdose, anti-cholinergic effects such as urinary retention, dry mouth, red skin, tachycardia, gastrointestinal peristalsis, airy vision disorders can occur and Cheynes-Stokes-style breathing has also been reported.

Treatment

In the case of oral poisoning, wash the intestines with activated carbon followed by Magnesi Sulfate (15%).

Buscopan overdose symptoms respond to sympathetic nerve stimulants. Pilocarpin should be used for patients with glaucoma. Cardiovascular complications should be treated according to normal treatment principles. In case of respiratory paralysis: Consider the intubation, artificial ventilation. The catheter may be placed in case of urinary retention. Should supplement support treatments when needed.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using Buscopan 10 you can experience unwanted effects (ADR):

Many adverse effects listed below are due to the Buscopan's cholinergic resistance.

Side effects are classified according to the frequency of appearance with the following convention:

Very common (≥ 1/10); Common (≥ 1/100,

immune system disorders

Unknown*: Anaphylaxis, anaphylaxis, shortness of breath, other hypersensitivity.

Heart disorders

Uncommon: tachycardia.

Digestive disorders

Less: dry mouth.

Skin and subcutaneous disorders

Uncommon: skin reaction (such as urticaria, itching), abnormal sweat.

Unknown*: rash, erythema.

Rare: Urinary retention

*The adverse reaction is recorded after the sales. With 95%reliability, the frequency of the appearance of the reaction is not larger than the less common group (3/1368) but may be lower. It is impossible to accurately estimate the frequency because this side effect does not occur in a clinical trial conducted on 1368 patients.

Instructions on how to handle ADR:

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Buscopan 10 contraindications in the following cases:

Hypersensitivity to any ingredients of any atropin medication or any Atropin. congestion.

Pathological tachycardia.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

In severe cases, unexplained abdominal pain is prolonged or progressive, or appears along with symptoms such as fever, nausea, vomiting, changes in defecation, abdominal pain when examining, reducing blood pressure, fainting or blood in the stool, should immediately ask your doctor's opinion.

Be cautious when using 10 mg Buscopan tablets in cases characterized by tachycardia such as thyroid poisoning, heart failure and cardiac surgery because the drug can worsen the tachycardia.

Due to the risk of complications of anti -anti -cholinergic drugs, caution should be used for patients who are prone to gut or urinary clogged. Due to the ability to resist cholinergic resistance can reduce sweat, so cautious when using Buscopan in patients with fever.

Interior pressure increases may occur when using cholinergic drugs such as Buscopandor in patients with narrow -angle glaucoma that have not been diagnosed and treated. Therefore, patients should consult an eye specialist if the pain progresses, red eyes accompanied by loss of vision during or after using Buscopan.

Sucrose-containing sacks (41.2 mg) so patients with rare genetic diseases are free-intolerant, Glucosegalactose or Sucrase-Isomaltase Should not use Buscopan tablets.

The effect of drugs on driving and operating machinery

There has been no research on the ability to drive and operate machinery.

Due to the possibility of vision disorders, patients should not drive or operate the machine if affected.

Using drugs for women during pregnancy and lactation

data using hyoscin butylbromid on pregnant women is limited.

Animal studies do not show direct or indirect harm to toxicity on fertility.

There is no information on the excretion of Buscopan and the metabolites into breast milk.

As preventive measures, avoiding Buscopan during pregnancy and lactation.

has not conducted research on affecting human fertility.

Drug interaction

Buscopan can cause increased cholinergic resistance of antidepressants three and four rounds, antihistamine, psychotic anti -dysplasia, quinidine, amantadine, disopyramid and other anti -cholinergic drugs (such as Tiotropium, ipratropium, Atropine -like compounds).

Treatment combined with dopamine antagonists such as metoclopramide can reduce the effect of both drugs on the gastrointestinal tract.

The effect of the tachycardia of the sympathetic beta stimulant can increase due to Buscopan.

Antacids or anti -diarrhea adsorbent medications may reduce the absorption of anti -cholinergic drugs, leading to reducing treatment effectiveness. Buscopan should be used at least 1 hour before taking the above drugs.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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