Busfan 8 SPM treatment supports painful spasms in vertebral degeneration (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Thiocolchicoside
Ingredient SPM Joint Stock Company

Ingredient

Composition information	Content
Thiocolchicoside	8mg

Uses

Indications

Busfan 8 drugs are indicated for treatment to support painful spasms:

Spine degeneration diseases and spinal posture disorders: neck scoliosis, back pain, back pain.

Traumatic and neurological diseases (with spasticity) and in rehabilitation.

Dysmenorrhea.

Pharmacology

thiocolchicoside is a sulfur synthetic compound of a natural glucoside extracted from the "colchique" tree.

In vitro, Thiocolchicoside only links to Gaba-A and sensitive Glycine receptors Strychnine. Thiocolchicoside acts as a GABA-A receptor antagonist, its muscle relaxation effect can be gained in the spine, through a conjugate regulatory mechanism, although the Glycinergic mechanism cannot be excluded. Interactive characteristics of Thiocolchicoside with GABA-A receptors of qualitative and quantitative are shared by its main circulating metabolites, which leads to glucuronicization.

In Vivo, the muscle relaxation properties of Thiocolchicoside and the main metabolites show that the predictable models are different in rats and rabbits. The lack of muscle relaxation effect of Thiocolchicoside in the rats is lesions of the spine, showing the effect on the vertebra of this compound. Thiocochicoside is also found to have anti -inflammatory and analgesic effects in some test samples after drinking, subcutaneous injection, intramuscularly and peritoneal injection. Moreover, pharmacological studies -Eg, thiocolchicoside and its main metabolites show that there is no sedative effect.

Dynamic pharmacokinetics

The muscle relaxation effect of thiocolchicoside appears average within 1-2 hours after drinking. Birth is 25% for oral. The average peak concentration in plasma is 4.5 hours and is noted that there is no accumulation after the dose of 8mg/day is repeated within 7 days.

thiocolchicoside is metabolized in plasma. Thiocolchicoside is converted into 3 main substances. Two types of circulating are thiocolchicoside aglycon and glucuronic derivatives of thiocolchicoside, they are active substances. On average, the amount of testocolicoside excreted in urine is 8% when using a single dose. Large quantities of thiocolchicoside are eliminated through feces.

Before taking Busfan 8 SPM treatment supports painful spasms in vertebral degeneration (3 blisters x 10 tablets)

How to use

oral medication.

Dosage

Adults

Starting dose: 16mg/day.

acute form: can be increased from half a dose every 2 days to double the starting dose, or the exception tripled (short -term treatment).

Prepare for motor therapies: Note the necessary time (1-2 hours) for the drug to work.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Busfan 8, you may experience unwanted effects (ADR).

Perhaps on the skin.

rarely

digestive disorders, diarrhea, stomach pain.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Busfan 8 drug control for cases of hypersensitivity to Thiocolchicoside or any ingredient of the drug.

Be cautious when using

reduce the dose when necessary if diarrhea appears after overdose.

The ability to drive and operate machinery

Although this drug is rarely causing drowsiness, this ability must be noted.

Pregnancy

Animal studies do not show that Thiocolchicoside has a teratogenic effect. Clinically, studies on pregnant women are limited, so it is impossible to conclude that taking drugs during pregnancy is completely harmless. Do not use for pregnant women because of the risk of genetics.

Breastfeeding period

Should not be used for women who are breastfeeding by thocolchicoside are excreted through breast milk.

Drug interaction

No report.

Storage

Store in a dry place, avoid light, temperatures below 30 ° C.

Other drugs

Disclaimer

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