Cadaffast 120 USA Pharma Medicines treat chronic urticaria, reduce allergic rhinitis (3 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 3 blisters x 10 tablets
Ingredient Fexofenadin HCl

Ingredient

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Composition information	Content
Fexofenadin HCl	120mg

Uses

indications

Cadaffast 120 medicine is indicated in adults and children aged 12 and older in the following cases:

Reduce the symptoms of allergic rhinitis such as sneezing, nasal itchy nose, stuffy nose, itching, pharynx, throat.

Treatment of symptoms of malicious chronic urticaria (reducing itching and quantity of urticaria).

Pharmacology

Fexofenadin is a second -generation antihistamine drug, with specific antagonistic and selective effects on peripheral H1 receptors.

The drug is a metabolic substance that is active of terfenadin but no longer toxic to the heart.

Fexofenadin has no significant effect on acetylcholine antagonism, dopamine antagonistic and has no effect on inhibiting receptors of Alpha-1-adrenergic. At the treatment dose, the drug does not cause sleep or affects the central nervous system.

The drug has a fast and prolonged effect due to the slow -attached drug into the H1 receptor, forming a sustainable complex and separating slowly.

pharmacokinetics

absorption:

Good absorption drug when taken orally. Food reduces the peak concentration in plasma by about 17% but does not slow down the time to reach the peak concentration of the drug.

Distribution:

The ratio of the plasma protein of the drug is 60 - 70% mainly with albumin and alpha 1 - Glycoprotein acid.

The distribution volume is 5.4 - 5.8 liters/kg. It is unclear whether the drug is through the placenta or excretion in breast milk, but when using terfenadin has detected fexofenadin is the metabolic substance of terfenadin in breast milk. Fexofenadin does not pass the blood - brain barrier.

Metabolism:

approximately 5% of the dose of the drug is metabolized. About 0.5 - 1.5% are metabolized in the liver thanks to the cytochrome P450 enzyme system into non -active substances, 3.5% are converted into methyl ester derivatives, mainly thanks to the intestinal bacteria.

Era:

FEXOFENADIN SELLING TIME OF 14.4 hours, longer in renal failure.

Mainly eliminated drugs (approximately 80%), 11 - 12% of the dosage is eliminated in urine in constant form.

Pharmacokinetics in people with renal failure:

CLCR 41 - 80 ml/minute: The peak concentration is 87%high, the selling time is longer than 59%.

CLCR 11 - 40 ml/minute: The peak concentration is higher than 111%, the sale time is longer than 72%.

CLCR

Before taking Cadaffast 120 USA Pharma Medicines treat chronic urticaria, reduce allergic rhinitis (3 blisters x 10 tablets)

How to use

Cadaffast 120 drugs for oral, time to take the drug does not depend on meals.

Dosage

The drug is only used as prescribed by the doctor.

Lieu uses usual in the following cases:

Adults and children over 12 years: Treatment of allergic rhinitis and indefinitely chronic hives recommended as 120 mg/ part/ day.

Children under 12 years: 120 mg dose is not suitable for this object, so it should be switched to a more appropriate dosage form.

No dose adjustments in patients with liver failure and elderly people have normal kidney function.

People with kidney failure or blood decomposition, the dose of 120 mg is not suitable for this object, so the dosage form has a more suitable dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose

Overdose: Sleep, dizziness, dry mouth.

Handling: Using conventional measures to remove the drug that has not been absorbed in the digestive tract. Support support and symptomatic treatment. Hemolysis is negligible in blood concentration (1.7%). There is no specific antidote.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

The unwanted effects of the drug are not affected by the dose, age, gender and race of the patient.

Common, ADR> 1/100:

Neurological: Drowsy, tired, headache, insomnia, dizziness.

digestive: nausea, indigestion.

Other: viral infections (colds, flu), dysmenorrhea, upper respiratory infection, itchy throat, cough, fever, otitis media, sinusitis, back pain.

Uncommon, 1/1000

Neurological: Fear, sleep disorders, nightmares.

digestion: dry mouth, abdominal pain.

Rare, 1/10000

Skin: Ban, urticaria, itching.

Hypersensitivity reactions: Evana, chest tightness, shortness of breath, redness, anaphylaxis.

Notify the doctor with unwanted effects when using the drug.

Instructions on how to handle ADR:

The unwanted effects of the drug are usually mild, only 2.2% of patients have to stop the drug due to the unwanted effects of the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cadaffast 120 contraindications in the following cases:

Patients with a history of hypersensitivity to any ingredients of the drug.

Be cautious when using

Although the drug has no toxicity on the heart, it is still necessary to be careful to monitor when using fexofenadin for people who are at risk of cardiovascular or have Q-T interval in advance.

Do not use any other antihistamines when using fexofenadin.

Be careful and adjust the appropriate dose when taking the drug for people with renal failure because the concentration of drugs in plasma increases due to prolonged semi -exhaust time. Be careful when taking medicine for the elderly (over 65 years old) often has a decline in kidney physiology.

Safety and effectiveness of drugs in children under 6 years of age have not been identified. Fexofenadin should be stopped at least 24 - 48 hours before conducting injections in the skin.

Use fexofenadin to make psoriasis worse.

Caution with lactose components: Patients with rare genetic disorders in galactose tolerance, lactase lactase deficiency. Or Glucose - Galactose absorption disorders should not use this drug.

The effect of drugs when driving and operating machinery

The drug is less likely to cause drowsiness, but still need to be cautious when driving or controlling machinery requires alert.

Pregnant women

Because there is no complete research on pregnant women, only fexofenadin is used for pregnant women when the maternal benefits are superior to the risk of the fetus.

breastfeeding women

It is unclear whether the drug is excreted through breast milk, so it is necessary to be cautious when using fexofenadin for breastfeeding women.

Drug interaction

erythromycin and ketoconazole increases concentration and area under the concentration curve - time of fexofenadin in the blood, the mechanism may be due to increased absorption and reduction of this drug. However, interaction is not clinically significant.

Fexofenadin concentration may be increased by erythromycin, ketoconazole, verapamil, p-glycoprotein inhibitors.

Aluminum and magnesium antacids if used simultaneously with fexofenadin will reduce the absorption of the drug, so they must use these drugs about 2 hours apart.

Fexofenadin may increase alcohol concentration, TKTW sedatives, cholinergic substances.

Fexofenadin may reduce the concentration of acetylcholininology inhibitors (in TKTW), Betahistin.

Fexofenadin may be reduced by concentrations by acetylcholininininiserase inhibitors (in TKTW), amphetamine, anti -acid agents, grapefruit juice, rifampin.

Cavalry:

Fruit juice (oranges, grapefruit, apples) can reduce the bioavailability of fexofenadin by 36%. Avoid using fexofenadin with ethylic alcohol (alcohol) because it increases the risk of sedation (sleep).

Storage

Store drugs in a dry place, temperatures below 30 ° C, avoiding light.

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