Calcium Stella Vitamin C, PP treatment treatment for rickets and calcium supplements (2 blisters x 10 tubes x 5ml)

Vitamin C: Ability to reduce in many oxidation - reduction reactions. There are some biological functions of vitamin C clearly verified, including collagen biosynthesis, carnitin, catecholamine, tyrosin, corticosteroids and aldosterol. Vitamin C has also participated as a reducing agent in the drug metabolic enzyme system in microsom along with Cytochrom P450,. The activity of the drug metabolic enzyme system in microsom will be reduced without vitamin C. Vitamin C also regulates absorption, transportation, and storage of iron. Vitamin C is an effective antioxidant. Vitamin C immediately removes oxygen, reaction nitrogen (ROS = ROCTIVE OXYGEGE SPECIES and RNS = Reactive Nitrogen Species such as Hydroxyl, Peroxyl, Superoxyl, Peroxide and Nitroxyd), single oxygen and hypocloride, are toxic free radicals for the body. Using vitamin C completely loses the symptoms of vitaminc deficiency.

In the body, vitamin PP (nicotinamide) is made up of nicotinic acid. Nicotinamide performs functions after converting into Nicotinamide Adenine Dinucleotide (NAD), or Nicotinamide Adenine Dinucleotide phosphate (NADP). NAD and NADP plays a survival role in metabolism, as an oxidative - redox catalyst that is necessary for cell respiration, glycogen resolution, and lipid metabolism. In these reactions, this coenzym is acting as hydrogen transport molecules. Nicotinamide deficiency can occur with the lack of other B vitamins and can cause Pellagra disease.

pharmacokinetics

calcium is absorbed mainly through the small intestine thanks to the active transportation and passive diffusion mechanism. About 1/3 of calcium is absorbed, although this ratio may vary depending on the diet and the condition of the small intestine; In addition, the absorption of calcium in the case of calcium deficiency and in high physiological needs such as childhood, pregnancy or lactation. The excess calcium is excreted mainly through the kidneys. The amount of calcium is not absorbed along with the amount of secretion into the bile and pancreas is eliminated into the feces. A small amount is lost through sweat, skin, hair, and nails. Calcium through placenta and distribution into breast milk.

Vitamin C is easily absorbed through the gastrointestinal tract and widely distributed in the body tissue. The plasma concentration of vitamin C increases when the oral dose increases until the body reaches a stable state with a dose of about 90 - 150 mg/day. The reserve of vitamin C in a healthy body is about 1.5g, although it can reserve more when the amount of use may be over 200 mg/day. The concentration of medication in leukemia and platelets is higher in red blood cells and plasma. Vitamin C metabolizes reversible into dehydrooscorbic acid; Some will be converted into ascorbat-2-Sulfate inactive and oxalic acid is excreted in the urine. The amount of vitamin C exceeding the needs of the body is also quickly eliminated in the form of unchanged urine; This usually happens when used in excess of 200 mg/day. Vitamin C through the placenta and is distributed into breast milk. The drug is excluded by blood separation.

Vitamin PP (Nicotinamide) is easily absorbed through the gastrointestinal tract after drinking and widely distributed into the body tissue. The main transformation path is transformed into n-methylnicotinamide and the derivatives of 2-Pyridon and 4-Poridon; Nicotinuric acid is also formed. A small amount of nicotinamide is excreted in the form of unchanged urine when using therapies; However, when the dose is larger, the amount of drug excreted in the form of unchanged will increase.

Avoid high doses of nicotinamid for patients:

Be cautious when using

note the sugar content (2.5g/5ml) and the sodium content when indicated for diabetics and salt patients.

Be careful to use calcium salt for patients with renal impairment or diseases related to hypercalcemia such as sarcoid disease and some malignant tumors.

Using high -dose ascorbic acid can lead to an increase in the metabolism of the drug ("greasy phenomenon"), until the normal dose decreases, it will lead to Scorbut disease. High doses of vitamin C during pregnancy can lead to scorbut disease for babies.

Hematopsius can occur when using ascorbic acid for babies with glucose-6-phosphate dehydrogenase deficiency and other healthy premature babies.

Should use nicotinamid caution for patients with a history of stomach ulcers and diabetics, gout or liver failure.

Calcium stella vitamin C, PP 5ml is not harmful when taking the daily recommendations daily (10 - 20 ml x 2 times/day in the morning and noon). However, pregnant women should be provided with adequate diet. Using too many vitamins and other minerals can be harmful to the fetus or mother. Vitamin C and nicotinamid with additional doses are often considered safe during pregnancy when using the recommended dose.

The ability to drive and operate machinery

does not affect the ability to drive and operate machinery ..

pregnancy

is not harmful when used at the usual daily recommended dose (10-20ml x 2 times/day. However, pregnant women should be provided with a full diet. Excessive use of vitamins and minerals can be harmful to the fetus and mother. Vitamin C and Nicotinamide with additional doses are often considered safe during pregnancy recommendations

Lactation period

Not harmful when used at the usual daily recommended dose (10-20ml x 2 times/day. Should be provided in adequate diet.

Drug interaction

tetracylin: should be used at least 3 hours to avoid calcium affecting the absorption of tetracylin.

digitalis: Using at the same time can increase the toxicity of digitalis because the drug contains calcium.

diphosphonate: There is a risk of reducing the absorption of diphosphate in the digestive tract, so it should be taken at least 2 hours apart.

Thiazid diuretics: can increase blood calcium due to reducing calcium elimination in the kidneys, so it is necessary to be careful when coordinated.

aspirin: simultaneously use vitamin C with aspirin increases the secretion of vitamin C and reduces aspirin excretion through urine. Aspirin can reduce the clearance of nicotinamide.

Simultaneous use of vitamin C and fluuphenazin leads to a decrease in the concentration of fluhenazin in plasma.

The presence of vitamin C in urine increases false glucose if quantitative with Sulfate reagent and false reduction of glucose if quantitative with glucose oxidase method.

The risk of muscle disease or muscle prize if it is possible to increase when using nicotinamide along with statin groups.

Nicotinamid may increase demand for insulin or oral blood glucose medications.

Nicotinamide may increase the effects of lymphadenopathy and vasoconstrictors leading to hypotension