Caldihasan Hasan prevents and treats vitamin D deficiency, calcium (3 blisters x 10 tablets)

Dosage form Tablet
Specifications Box of 3 blisters x 10 tablets
Ingredient Calcium carbonate, cholecalciferol
Indication Osteoporosis, lack of calcium
Contraindication Nephrotic syndrome, kidney stones, hypercalcemia, hyperactive urine, drug allergies

Ingredient

Composition information	Content
Calcium Carbonate	1250mg
Cholecalciferol	125iu

Uses

indications

Caldihasan drugs are indicated in the following cases:

Preventing and treating osteoporosis in adults, rickets in children.

Supplementing with calcium and vitamin D daily in the growth period, pregnant and lactating women or due to calcium deficiency diet.

Pharmacokology

calcium

Calcium cans are essential for many biological processes: stimulating neurons, releasing neurotransmitters, muscle contraction, preserving membrane and coagulating. Calcium cans also help the secondary communication function for the activity of many hormones.

On the cardiovascular system: Calcium cans are essential for stimulating and contracting myocardial as well as for electrical impulses on some areas of the heart muscle, especially through the atrial node.

On the muscular nervous system: Calcium can play an important role in stimulating and muscle contraction.

cholecalciferol (vitamin D3)

Cholecalciferol (Vitamin D3) has the main function of maintaining normal calcium and phosphorus concentration in plasma by increasing the effectiveness of the absorption of minerals from diet, in the small intestine, increasing mobilization of calcium and phosphorus from bone to blood.

Dynamic pharmacokinetics

calcium

absorption

calcium is absorbed mainly through the small intestine thanks to the active transportation and passive diffusion mechanism. About 1/3 of calcium is absorbed, although this ratio may vary depending on the diet and small intestine. Vitamin D helps increase calcium absorption.

Distribution and metabolism

99% of calcium in the body is concentrated in bones and teeth, the remaining 1% is distributed in intracellular and extracellular fluid. About 50% of calcium concentration in plasma in the form of ionization of physiological activity; About 5% form a complex with phosphate, citrate or other anion and the remaining 45% are linked to protein, mainly albumin.

Elimination

The amount of calcium ions is discharged from urine depends on glomerular filtration and reabsorption in the renal tubules, more than 98% of the amount of calcium ion filtered through the glomerular reabsorption into the bloodstream. A significant amount of calcium is deducted from milk during breastfeeding, a part of sweat and stool.

cholecalciferol (Vitamin D3)

absorption

cholecalciferol is well absorbed through the gastrointestinal tract, mainly from the small intestine.

Distribution and metabolism

cholecalciferol is hydroxylation in the liver forming 25 - hydroxycholeciferol. This substance continues to be hydroxylated in the kidneys to form a metabolic 1.25 - dihydroxycholeciferol is active; This is a substance that increases calcium absorption. The non -metabolic part is stored in fat and muscle tissue.

Elimination

cholecalciferol and its metabolites are excluded mainly through bile and feces, only a small amount appears in the urine.

Before taking Caldihasan Hasan prevents and treats vitamin D deficiency, calcium (3 blisters x 10 tablets)

How to use

Take oral use. Drink after eating or as directed by the doctor.

Dosage

Adults or children, depending on the needs of daily calcium.

Take 1 - 2 capsules/day.

Pregnant and lactating women: Do not use vitamin D more than 400 ĐVQT/day (about 3 CALDIHASAN/day).

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

calcium

Symptoms

Anorexia, nausea, vomiting, constipation, abdominal pain, muscle weakness, mental disorders, thirst, multi -urinary, kidney calcium infection, arrhythmia and coma.

Handling

intravenously sodium chloride solution 0.9%. For forced diuretic in Furosemid or ethacrynic acid to increase calcium and sodium excretion when using too many 0.9%sodium chloride solutions. Monitor the electrocardiogram and can use beta-adrenergic blockers to prevent heavy arrhythmia. Bloody stool can be used, Calcitonin and Adrenocorticoid can be used in treatment. Monitor your blood calcium concentration regularly.

cholecalciferol (Vitamin D3)

Symptoms

Anorexia, fatigue, nausea and vomiting, constipation or diarrhea, multi -urinary, night urine, sweating, headache, thirst, sleep, and dizziness.

Handling

Stop drugs, stop calcium supplements, maintain a diet with low calcium, drink plenty of water or infusion. Corticosteroids can be used or other drugs (such as Furosemid and ethacrynic acid) to reduce calcium levels in serum. Artificial kidney dialysis can be used or abdominal separation to release free calcium from the body. If vitamin D poisoning is acute, vitamin D can be absorbed by causing vomiting or gastric lavage. If the drug has passed the stomach, treatment with mineral oil can promote vitamin D elimination through feces.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Caldihasan, you may experience unwanted effects (ADR).

Using oral calcium -containing oral salt can irritate the digestive system, cause constipation and discomfort in the stomach.

Use vitamin D in normal doses daily often not toxic. However, vitamin D can occur when high or prolonged dosage treatment, or when increased in response to normal dose of vitamin D and will lead to clinical manifestations of calcium metabolic disorders.

Hypercalcemia and toxicity of vitamin D are common with the following effects:

Neurological: Weak, tired, sleep, headache.

Digestive: Anorexia, dry mouth, metal flavor, nausea, vomiting, cramps in the abdomen, constipation, diarrhea, dizziness.

Other agencies: tinnitus, loss of air conditioning, foreign rash, reduced muscle tone, muscle pain, bone pain and easily stimulated.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

CALDIHASAN drug is contraindicated in the following cases:

Hypersensitivity to the ingredients of the drug.

Diseases accompanied by blood calcium hypertension syndrome (such as in patients with hyperthyroidism, overdose due to vitamin D, bone malignant tumors ...), severe hypercalcium, kidney stones, ureteral stones, severe kidney failure, dynamic osteoporosis, being treated with vitamin D.

Be cautious when using

using too much calcium salts can lead to hypercalcemia.

It is necessary to notify the doctor about the history of the disease, especially in the diseases: Sarcoidosis) or parathyroidism (which can cause increased sensitivity to vitamin D), kidney failure, History of kidney stones, heart disease, atherosclerosis, liver disease, intestinal disease (Crohn's disease, Whipple's), gastricular shortage ...

Need to monitor calcium levels in blood and urine in patients with renal impairment, history of kidney stones ... or are using vitamin D if long -term treatment in these patients.

Because the drug contains vitamin D, the use of more vitamin D needs medical monitoring to avoid overdose.

Not used simultaneously with other tonic products 2 containing calcium and vitamin D.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

If using vitamin D at a larger dosage than the daily additional dose has been recommended (RDA dose) for normal pregnant people (400 ĐVQQ/day) may occur risk. Therefore, Vitamin D should not be used at a larger doses than RDA for pregnant women.

should only use the drug to supplement vitamin D and calcium if the diet is not enough or lack of ultraviolet radiation.

consult your doctor before you want to take the medication.

The period of breastfeeding

vitamin D is excreted in milk. Do not take the drug in a larger dose than the RDA.

should only use the drug to supplement vitamin D and calcium if the diet is not enough or lack of ultraviolet radiation.

consult your doctor before you want to take the medication.

Drug interaction

should not treat Caldihasan with cholestyramin simultaneously or Colestypol hydrochloride (because it can lead to reduced vitamin D absorption); Phenobarbital, Phenytoin (increasing vitamin D conversion into non -active substances, reducing calcium absorption); corticosteroid (obstructing the effect of vitamin D); Heart glycosides (toxicity of glycosides support hypertension due to hypercalcemia, leading to arrhythmia).

Simultaneous treatment of vitamin D with thiazid diuretics in people with parathyroidism can lead to hypercalcemia. Dosage reduction or temporary vitamin D use.

Excessive use of mineral oil can also hinder the absorption of vitamin D through the gastrointestinal tract.

Therodenal elimination inhibitors: thiazid, clopamid, ciprofloxacin, chlorthalidon, anti -convulsions.

Calcium reduces the absorption of Demeclocyclin, Doxycyclin, metacyclin, minocyclin, oxytetracyclin, tetracyclin, enoxacin, fleroxacin, levofloxacin, lomefloxacin, norfloxacin, ofloxacin, pefloxacin, iron, iron, iron, iron, and other substances.

Diets with phytat, oxalate reduces calcium absorption because of creating difficult complexes to absorb.

Storage

Where dry, less than 30 ° C.

Other drugs

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