C.Ales medicine 20mg Pharimexco treat erectile dysfunction (1 tablet)

Dosage form 1 tablet box
Specifications Tadalafil
Ingredient Impotence, erectile dysfunction, physiological weakness

Ingredient

Composition information	Content
Tadalafil	20mg

Uses

indications

C.LES 20 mg is indicated in the following cases:

Used for men aged 18 and over. Do not use drugs for women. (PDE5).

When sexual stimulation leads to local oxidation nitric release, the PDE5 inhibitor of Tadalafil increases the level of GMP ring (cyclic guanosin monophosphate) in the cave. This leads to smooth muscle relaxation and increases blood into the penis tissue, thereby causing penis.

Tadalafil does not cause erections without sexual stimulation. Tadalafil selectively inhibits PDE5 - is an enzyme found in caves smooth, blood vessel and organ, musculoskeletal, platelet, kidney, lung and cerebellum.

On PDE5 Tadalafil is 10,000 times stronger than PDE1, PDE2, PDE4 and PDE7, which are the enzymes found in the heart, brain, blood vessels, liver and other organs. Tadalafil acts on PDE5 stronger than> 10,000 times PDE3, a type of enzyme found in the heart and blood vessels.

Tadalafil acts on PDE5 about 700 times stronger than PDE6, is a yeast found in the retina and causes image load. Tadalafil acts on PDE5 strongly> 9,000 times PDE8, PDE9 and PDE10.

Tadalafil acts on PDE5 more than 14 times stronger than PDE11A1 and 40 times compared to PDE11A4, two of the 4 known forms of PDE11. PDE11 is a enamel found in the prostate of humans, testicles, skeletal muscles and other tissues.

Pharmacokinetics

absorption

Tadalafii is quickly absorbed after drinking and the average maximum plasma concentration (CMAX) is about 2 hours after drinking. Food does not affect the level of tadalafil's absorption, so it can be used for common tadalafil or after eating.

Distribution and metabolism

The average volume of drug distribution after use is about 63L.

At the treatment concentration, 94% of Tadalafil associated with plasma proteins. The cohesion with protein is not affected by kidney function. Tadalafil is metabolized mainly by Cytochrom P450 (CYP) in the same form, Figure 3A4, metabolites circulated mainly Methylcatechol Glucuronic.

Era:

Tadalafil's medium clearance is 2.5 hours and the average half -life is 17.5 hours on healthy people. Tadalafil is excreted mainly in the form of non -effective metabolites, mainly in stool (about 61% of the drug) and with less than the urine (about 36% of the drug).

Before taking C.Ales medicine 20mg Pharimexco treat erectile dysfunction (1 tablet)

How to use

take medicine before having sex for at least 30 minutes.

Dosage

The usual dose is 1 tablet when necessary. Do not use more than 1 tablet daily.

Patients with renal failure:

Creatinine clearance 30-50 ml/minute dose is ½ tablet (10mg)/time for 48 hours.

Creatinine clearance

Patients with liver failure:

Light or medium: Maximum dose of tablets/1 time/day.

Severe: Do not use C.Ales® 20mg.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

How to handle:

Stop medication and apply standard support measures and immediately take patients to the nearest hospital.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using C.Ales®, you may experience unwanted effects (ADR).

Common, ADR> 1/100

muscle: back pain, muscle pain.

Systemic: dizziness, blush, nasal mucosa, very often headache. digestive: very often occurs is indigestion.

Uncommon, 1/1000

Eyes and vision: Eyelid swelling, sensations described as pain in the eye and conjunctiva.

Rare, 1/10000

Digestive: sore throat, difficulty swallowing;

vision: dizziness, visual disorders; genital: Penis pain.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindications:

C.Ales® 20 mg contraindicated in the following cases:

Women and children under 18 years old.

Patients with hypersensitivity to Tadalafil or any ingredients of the drug.

Concomitance Tadalafil with organic nitrates in any form.

Patients with new myocardial infarction within 90 days, patients with unstable angina or angina occurs during intercourse, patients with severe heart failure for 6 months, patients with untrainy heart arrhythmia, low blood pressure (

Caution when used

Do not use drugs for patients with myocardial infarction, unstable chest pain, ventricular arrhythmia, stroke, transientive anemia.

Note if the erection lasts more than 4 hours and the penis pain within 6 hours must go to the medical facility for care.

Eye effect: Stop using drugs in case of sudden vision loss in one or both eyes.

Sudden hearing loss: Stop taking the drug in case of sudden decrease or hearing loss, can be accompanied by tinnitus and dizziness.

Caution for patients with diseases that can cause penis pain (such as sickle cell anemia, multiple marrow, leukemia).

Caution for patients with penis anatomy (such as an angle penis, cavity fiber, peyronie disease).

The ability to drive and operate machinery

Prudent use of Tadalafil before driving a train or operating machinery.

Pregnancy

Not for pregnant women.

breastfeeding period

Not used for nursing women.

Drug interaction

selective inhibitors CYP3A4 such as ketoconazole, increasing the area under the curve (AUC) of Tadalafil by 107% compared to the AUC value of Tadalafil at a dose of 10mg alone.

A few enzyme inhibitors such as ritonavir or saquinavir and other CYP3A4 inhibitors such as erythromycin, clarythromycin, otraconazole and grapefruit juice when used with Tadalafil need to be cautious because they can increase the plasma concentration of Tadalafil.

CYP3A4 induction such as rifampicin reduces the area under the curve (AUC) Tadalafil to 88% compared to the AUC value of Tadalafil at a dose of 10 mg when used alone. Simultaneous use of other CYP3A4 induction substances such as phenobarbital, phenytoin and carbamazepine will reduce the concentration of Tadalafil in plasma.

Tadalafii shows signs of increased nitrate lowering effects, therefore, Tadalafil is not used for patients who are taking any form of organic nitrate. Tadalafil does not inhibit or the CYP450 homogeneous touch includes CYP1A2, CYP2D6, CYP2E1, CYP2C9.

Tadalafil has no effect on changing prothrombin time when used with warfarin . Patients who use the Tadalafil period with antihypertensive drugs will probably have hypotension but often less and less clinically changing. No change on the concentration of Tadalafii 3 hours after taking the drug simultaneously with alcohol. Tadalafii increases the bioavailability of Ethinyl -estradiol oral use.

Magnesium hydroxid, aluminum hydroxid) reduces Tadalafil absorption.

Alpha - Blocker: Be careful when using PDE5 inhibitors (including Tadalafil) with Alpha - Blocker because PDE5 inhibitors block the effects of vasodilators and lowering blood pressure drugs.

Storage

In a cool dry place, temperatures below 300C, avoid light.

To be out of reach of children.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.