Cammic 500mg Vinphaco medicine for treatment and prevention of bleeding (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Tranexamic acid
Ingredient Menopause, bleeding syndrome

Ingredient

Composition information	Content
Tranexamic acid	500mg

Uses

Indications

Cammic medicine for treatment in a short time of excessive fibrin bleeding (during and after tooth extraction in people with bleeding, prostate removal surgery, cervical removal, tooth extraction in Hemophili people, hematuria, menstrual bleeding, nose bleeding ...).

Genesis Preventive Preventive.

Pharmacology

Pharmacy: ATC code: B02AA02

Tranexamic acid is a synthetic conductor of Lysin amino acid that has anti -fibrin elimination effect, inhibits fibrin decomposition in blood clots. The main mechanism of action of Tranexamic acid is to prevent plasminogen and plasmin attached to fibrin, thus preventing the solubility of the hemostatic button; Plasmin's direct inhibitor only occurs only at a low level. Fibrin's natural chemistry inhibitors, stabilizing blood clots.

The essential concentration of tranexamic acid in plasma is 5 - 10 micrograms/ml to have the effect of inhibiting fibrin.

In vitro: Tranexamic acid works similar to aminocaproic acid but 10 times stronger, Tranexamic acid at a concentration of 1 mg/ml does not cause platelets to collect. At a concentration of up to 10 mg/ml of blood, it has not affected the number of platelets, blood clotting time or blood clotting factors or blood citrate in normal people. But Tranexamic acid is at a concentration of 10 mg and 1 mg/ml of blood prolonged thrombin time.

pharmacokinetics

tranexamic acid is absorbed from the digestive tract, reaching the highest concentration in plasma after about 3 hours. The bioavailability of the drug is about 30-50%. The drug is widely distributed in the body, attaching very little to plasma protein (3%). The distribution of adults is 9 - 12 liters. The drug passes the placenta and breast milk (1% compared to the serum), into the cerebrospinal fluid (10% compared to plasma). The drug is quickly distributed to joint fluid and synovial fluid in joint fluid, the concentration of the drug is similar to the serum. The disposal time of Tranexamic acid in joint fluid is about 3 hours. Tranexamic acid levels in some other tissues are lower than blood concentrations. The drug also entered the hydrogenated, the drug also found in semen still inhibiting fibrin but does not affect sperm movement.

Sell waste time in plasma is about 2 hours. After drinking, 39% of the drug is excreted in the form of unchanged urine.

Before taking Cammic 500mg Vinphaco medicine for treatment and prevention of bleeding (10 blisters x 10 tablets)

How to use

Take oral use.

Dosage

Dosage recommended:

Treatment in a short time of excessive fibrin bleeding: taking 1.0 - 1.5 g/time (or 15 - 25 mg/kg), 2-4 times a day.

Dental surgery for people with bleeding diseases: Take 25 mg/kg, 3-4 times a day, start a day before surgery.

Nasal bleeding: Take 1.0 g/time, 3 times a day in 7 days.

Genetic angioedema: Take each time 1.0 - 1.5 g, 2-3 times a day.

Menstrual menstruation: Start treatment when bleeding is severe.

The recommended dose is 2 capsules/time x 3 times/day, up to no more than 4 days. If menstrual bleeding is very severe, the dose may be increased but the total dose must not exceed 4 g per day (8 tablets).

Children: Do not use for children under 18 years old.

Elderly patients: Do not recommend for the elderly.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? There is no special measure to treat Tranexamic acid poisoning, using symptomatic and supportive treatments. Can cause vomiting, gastric lavage and active carbon. Maintain additional fluid to promote the excretion of the kidneys. Treatment with anticoagulants should be considered.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

The discomfort in the gastrointestinal tract is the most unwanted effect that can occur but will disappear when the dose is reduced.

Unwanted frequency frequency at a dose of 4 g/day:

Common, 1/100

Gastrointestinal disorders: Nausea, vomiting, diarrhea.

Skin and subcutaneous tissue disorders: skin allergic reactions.

Nervous disorders: convulsions, especially in the case of drug abuse.

Notice immediately to the doctor or pharmacist unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Cammic drug is contraindicated in the following cases:

Hypersensitivity to tranexamic acid or any ingredients of the drug. Warfarin anticoagulants or other anticoagulants.

Patients who are taking birth control pills.

Precautions when using

Causes of caution when taking the drug:

Patients should consult a doctor if menstrual bleeding does not decrease after three menstrual cycles.

Be cautious when using cammic in women over 45 years old.

Be cautious when using Cammic in patients with obesity, diabetes, people with polycystic ovary syndrome, History of endothelial cancer from supply 1, antagonistic to estrogen or tamoxifen.

Do not use drugs in patients with visual disorders.

Be cautious when used in people with cardiovascular disease, cerebrovascular disease or surgery to remove prostate through the urethra.

Use Tranexamic acid after subarachnom bleeding can increase the proportion of ischemic complications in the brain.

The drug contains lactose, need to be cautious with patients with Galact

Use drugs for women during pregnancy and lactation

Pregnant women: tranexamic acid through the placenta. Do not take medicine.

Lactating women: tranexamic acid secreted into breast milk but the concentration is only about 1% of the concentration in the mother's blood. Should consult a doctor before using the drug for women who are breastfeeding.

The effect of the drug on the ability to drive and operate machinery

Machinery operators, trains driving, higher working people and other cases: no impact or negligible effects.

Medicinal interaction

tranexamic acid against thrombolytic effects of fiber pepper products.

Do not use tranexamic acid dynamic with estrogen because it can cause more thrombosis.

Be cautious when using Tranexamic Acid with other hemostasis.

Simultaneous use of tranexamic acid with oral tretinoin can cause thrombosis in microchips.

Storage

In a dry place, temperatures below 30 ° C avoid light.

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