Cancetil 8mg Shinpoong Daewoo treat hypertension (30 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Candesartan
Ingredient Shinpoong

Ingredient

Composition information	Content
Candesartan	8mg

Uses

indications

cancetil is indicated in the following cases:

Treatment of hypertension, used or coordinated with other antihypertensive drugs. Albumin micronutrients or kidney disease The drug is quickly hydrolyzed into active substances as Candesartan during the absorption from the gastrointestinal tract. Candesartan is an Angiotensin II receptor blocker (ARB), selected on AT receptors, tightly connected and slowly separated from the receptor.

Compared to ACE inhibitors, the frequency of coughing in Candesartan Culilil users is lower. Candesartan does not bond/lock hormone receptors, other important ion channels of the circulatory system.

Dynamic pharmacokinetics

Oral bioavailability is approximately 14%. The peak concentration of serum (CMAX) is achieved after drinking about 3-4 hours. The bioavailability of the drug is not affected by food.

The drug is highly attached to plasma proteins (> 99%). The apparent distribution volume is 0.1 l/kg.

Candesartan is excreted mainly in the form of unchanged kidneys and bile. Half life eliminates approximately 9 hours. There is no accumulation of drugs when repeating the dose. About 26% of the dosage excreted through the kidneys in the form of Candesartan and 7% in the form of metabolites are not active, approximately 56% of the dose found in feces in the form of Candesartan and 10% in the form of non -active metabolites.

Before taking Cancetil 8mg Shinpoong Daewoo treat hypertension (30 tablets)

How to use

Take oral use. Can take medicine with or not with food.

Dosage

Hypertension

Dosage should be adjusted based on the patient's blood pressure response. The recommended starting dose is 8 - 16 mg x 1 time/day, can increase the dose to a maximum of 32 mg/day, drink only once or divided into 2 times.

Older people

No starting dose.

Patients with decreased intravascular volume, renal failure (including people who are hemolysis), mild to moderate liver failure

start at a dose of 4 mg and adjust according to the patient's response.

Note: The hypotension effect can be noticed after 2-6 weeks. If blood pressure is not controlled, it is possible to coordinate with another diuretics or antihypertensive drug.

heart failure

The recommended starting dose is 4 mg/day. Adjust to a maximum dose of 32 mg 1 time/day or maximum tolerance (by doubling the dose every 2 weeks).

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Hypotension and dizziness.

Handling

Symptomatic treatment immediately and monitor the signs of survival. Should put the patient on his back, high foot. If not improved, the volume should be increased by transmitting isometric saline. Can use sympathetic nerve stimulants if the above methods are not effective. Candesartan is not eliminated through hemolysis.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using cancetil, you may experience unwanted effects (ADR).

Common

Respiratory infections; dizziness/fatigue, headache, hyperkalemia; hypotension; kidney failure.

rarely

leukopenia, loss of granulocytes; cough; nausea; Increase liver enzymes, abnormalities of liver function, hepatitis; Evala, rash, urticaria, rash; Back pain, joint pain, muscle pain.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Cancetro drugs contraindicated in the following cases:

Hypersensitivity to Candesartan or any ingredients of the drug.

Pregnant women.

Severe liver failure or biliary obstruction.

Caution when using

kidney failure or heart failure

Should regularly monitor the concentration of potassium and creatinine serum in these objects, especially in people over 75 years old, need to adjust the dose according to blood pressure in humans with CLCR

Renal artery stenosis

The drug can increase urea and serum creatinine in these objects.

Hypotension

Can occur during treatment in people with heart failure, in people with hypertension with a decrease in internal vascular volume as well as in people who are taking high -dose diet. Precautions when starting therapy and should adjust the decrease in volume.

In anesthesia and surgery

Hypotension can occur and should be provided with intravenous and/or vasoconstrictors.

2 -leaf valve stenosis, aortic stenosis (congestion heart muscle disease)

Particularly cautious when indicating these objects.

Increase the original aldosteron

These objects usually do not respond to the drug.

Hemorrhage

may occur in high -risk patients.

General

In people with renal and vascular functions depend on the activity of the renin-angiotensimaldosterone system (people with severe congestive heart failure or kidney disease, including kidney transplantation), treatment with drugs acting on this system can cause acute hypotension, increase nitrogen compounds in the blood, urinary or acute but rare renal failure.

Genorose genetic disorders, Lapp lactase deficiency or glucose-Galactose are not used by this drug.

The ability to drive and operate machinery

dizziness or fatigue may occur during treatment.

Pregnancy

Do not use Candesartan in pregnant women. When detected pregnancy, stop the drug immediately and replace it with other therapies.

breastfeeding period

do not recommend using Candesartan and should be replaced with other drugs safer while breastfeeding.

Drug interaction

coordinated with other drugs in the treatment of heart failure

Can be coordinated with beta blockers, diuretics, digitalis or coordination of these drugs. It is not recommended to coordinate with ACEI or potassium -saving dtered (such as Spironolacton) and should be carefully assessed between benefits and potential risks when coordinating.

Potassium -saving diocesia, potassium supplements, potassium -generating salts and other drugs (such as heparin)

Can increase potassium concentration.

lithium

Do not recommend coordination (because it can cause increased recovery of concentration and lithium toxicity). If it is necessary to coordinate, you should carefully monitor blood lithium concentration.

Non-steroid anti-inflammatory (NSAID) (COX-2 inhibitors, acetylsalicylic acid (> 3 g/day) and non-selective NSAIDs)

may reduce the effect of lowering blood pressure, leading to reduced kidney function or acute renal failure, increasing blood potassium concentration, especially in people who have impaired kidney function. Should be careful when coordinating, especially in the elderly.

Drugs have hypotension effect

can increase the effect of lowering blood pressure.

Storage

Storage in closed packaging, in dry places, avoid light, temperatures below 30 ° C.

Other drugs

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