Candid-B Cream Glenmark treatment cream for skin fungal infections, candidiasis (15g)

Dosage form Tube
Specifications Clotrimazole, betamethasone dipropionate
Ingredient Glenmark

Ingredient

Composition information	Content
Clotrimazole	10mg
Betamethasone dipropionate	0.25mg

Uses

Indications

Candid-B are indicated for treatment on the spot of shallow fungal patients such as skin fungal infections, candidiasis, Tinea Versicolor, ... when accompanied by expressions of Eczema.

Pharmacology

Clotrimazole

Clotrimazole is an Imidazole derivative, which has an anti -fungal effect due to the synthesis of sterol of the mushroom. Clotrimazole inhibits the enzymes that convert 2.441-methylenediDrololanosterol into Demethylsterol, the precursor of ergosterol, an essential component of the fungus's cyteto film.

In minimum fungal killing concentration, clotrimazole causes leaks of intracellular phosho complexes into the surrounding environment along with the broken nucleic acid of the cell and increasing the potassium flow. It also leaks the essential intracellular components leading to the synthesis of molecules such as protein, lipid, DNA and polysaccharid.

Other mechanisms of clotrimazole fungal effects include influencing cytoplasmic membranes, affecting the transportation through the membrane, and metabolizing fatty acids.

Clotrimazole has a wide range of anti -fungal activity spectrum, including Candida spp. Histolytica, Histoplasma Capsulatum, Naegleria Fowleri, Nocardia spp., Paracoccidioides Brasiliensis and Sportotrichum

Beclometasone diproprionate

Beclometasone is a localized corticosteroids used on the spot with average strength. Corticosteroids have many mechanisms of action including anti -inflammatory effects, immunosuppressive and anti -cell proliferation. Anti -inflammatory effects due to reducing the formation, release and activity of intermediate substances that cause inflammation reduces the initial manifestations of the inflammatory process. Corticosteroid inhibits cell movement to the damaged area, reversed vascular dilatation and vascular permeability in the damage area, resulting in reducing the access of cells to the damaged areas.

This vascular effect reduces serum, swelling and discomfort. These immunosuppressive properties reduce response to hypersensitivity reactions immediately and late (tube III, IV). In addition, corticosteroids also prevent the approach of sensitive T cells and the target cells of the target cell. Anti -cell proliferation effect reduces the keratinization of psoriasis.

Pharmacokinetics

absorption

Clotrimazole's body absorption when applied to the skin is very low. Birth is less than 0.5%. Clotrimazole is not detected in serum and biochemical parameters are constant in animal studies using clotrimazole on the skin.

Corticosteroid's skin absorption level is influenced by many factors including excipients, the intactness of the epidermis and wound ice. Corticosteroids can be absorbed through healthy skin. Inflammation and/other skin diseases may increase skin absorption. The wound tape increases the absorption of corticosteroids through the skin. When absorbed through the skin, the pharmacokinetic properties of corticosteroids are similar to the body.

Distribution

After applying the skin, Clotrimazole goes into the horny layer, thorny layer, papillary layer and mesh of the skin. Clotrimazole concentration in the epidermis is higher than the minimum inhibitory concentration for most pathogenic fungi. The highest concentration in the horn layer (50 - 100 mcg/ml) and the lowest concentration in the papillary layer (1.53 - 3 mcg/ml).

Metabolism

Most Clotrimazole has been converted into inactive metabolites (2 main substances and 3 auxiliary substances) and eliminated through urine and feces.

Elimination

Clotrimazole is highly eliminated through feces, mainly through the secretion in the bile. Elimination through the kidney accounts for about 0.05 - 0.5% of the drug excretion. The waste sale time of the mother substance is 3.5 - 5 hours.

any amount of Beclometasone is absorbed through the skin, then metabolized in the liver and excreted through the kidneys.

Before taking Candid-B Cream Glenmark treatment cream for skin fungal infections, candidiasis (15g)

How to use

Rinse the contaminated and dry areas.

Apply a thin layer of Candid-B cream to the entire surface of infected skin.

In hairy areas, cut or turn before applying to the cream in direct contact with the skin.

Dosage

usually apply 2-3 times daily.

After the symptoms of Eczema are gone, it is necessary to switch to cream or candid anointing until completely ceased. Do not use Candid-B cream for more than 4 weeks. Do not cover the topical area.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

There is almost no overdose of clotrimazole.

For extension of skin corticosteroids that can inhibit the pituitary-pituitary axis.

Treatment

When using the drug overdose, it is necessary to treat symptoms. Symptoms of corticosteroid overdose are often recovered. Treatment of electrolyte imbalance if necessary. In cases of chronic poisoning, corticosteroid usage slowly.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Common, ADR> 1/100

No report.

Uncommon, 1/1000

No report.

Not determined frequency.

Skin: Skin atrophy.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

contraindicated

Candid-B anti-contraindications in the following cases: Patients with skin tuberculosis, chickenpox, herpes simplex, measles, seasonal bean disease, Single ulcerative skin ulcers, and hypersensitivity patients with any component of Candid-B.

Be cautious when using

using topical steroids for large skin areas, whether or not with tight bandages can lead to the absorption of steroids into the body, so it should be cautious. When there is closed bandage, stealing sweat, folliculitis or double dermatitis appears under the ice.

Do not apply to the eyes or ears if the eardrum is punctured.

Candid-B cream is well tolerated, if the irritation occurs, it is necessary to stop the drug.

The ability to drive and operate machinery

There is no effect of Candid B drug when used for drivers and machinery operation.

Pregnancy

should only use Candid B for pregnant women when the benefits are greater than the potential risk for the fetus. Do not use for a long time for pregnant women.

Clotrimazole: Class B for pregnant women.

Beclometasone dipropionate: Classification C for pregnant women.

breastfeeding period

Be cautious when used for breastfeeding women because they do not know if the drug will go into breast milk.

Interactive drug

There has been no report on Candid interaction b.

Storage

Store at a temperature not exceeding 30 ° C.

Other drugs

Disclaimer

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