Canditral 100mg Glenmark treatment for Candida, Lang Beng, Nail Mushroom, Foot Mushroom (10 small boxes x 4 tablets)

Dosage form Box of 10 odd boxes x 4 tablets
Specifications Itraconazole
Ingredient Glenmark

Ingredient

Composition information	Content
Itraconazole	100mg

Uses

indicated

Candida mushrooms in the mouth- throat. Ring, skin, interstitial skin. Or resistance to amphotericin b. Its mechanism of action is similar to imidazol antifungal drugs (for example, ketoconazole), which is the synthesis of Ergosterol synthesis in the fungal cell membrane due to inhibiting the cytochrom P450 system of mushrooms. Compared to ketoconazole, iTraconazole has a higher affinity for the mushroom cytochrom P450 and is weaker for the cytochrom P450 of mammals.

Antivirus spectrum: Research in test tubes and on the body shows that iTraconazole has a wider and stronger antifungal spectrum than ketoconazole and fluconazole. In test tubes, itraconazole has replaced the following fungal effects:

Leather fungus: Microsporum, Trichophyton and Epidermophyton Species. Disease: Candida Albicans and other Candida strains, Cryptococcus NeOForans

Mold: Aspergillusfumigatus, Aspergillusflavus. corresponding to 0.025-0.2; 0.025-0.05; and

pharmacokinetics

absorption:

iTraconazole is well absorbed when drinking immediately after meals or drinking with food, because food increases absorption. Relatively biological use of capsules with oral solution is over 70%. The solubility of itraconazole increases in the acid wall. Serum peak concentration reached 20 micrograms/liter, 4-5 hours after taking a dose of 100 mg at hunger, increasing to 180 micrograms/liter when drinking with food.

Distribution:

over 99% of the drug is associated with protein, mainly with albumin, only about 0.2% of the drug in free form. The drug dissolves well in lipids, the concentration in tissues is much higher in the serum.

Metabolism and elimination:

Itraconazole metabolizes the liver into many substances and then excreted through bile or urine. One of the metabolites is hydroxyitraconazole that has anti -fungal effects, and has double serum concentration of itraconazole concentration in a stable state. 3-18% of oral dose is excreted in feces in unchanged form. About 40% of the dose is exported to the urine in the form of a metabolic compound no longer active. A small amount excreted through the horny and hair layer.

iTraconazole is not excluded by a cup. The sale time after taking 1 dose of 100 mg is 20 hours, may be longer when taking high daily doses.

Before taking Canditral 100mg Glenmark treatment for Candida, Lang Beng, Nail Mushroom, Foot Mushroom (10 small boxes x 4 tablets)

How to use

oral tablets. Take the tablet with a glass of water.

Dosage

Adults:

Short -term treatment:

Candida mushrooms of vulva: 200mg, taken 2 times a day, only drink 1 day or 200mg, drink once a day, drink for 3 days. If in the high stunning area, it is necessary to treat for another 15 days at a dose of 100mg daily. Patients with AIDS or neutral leukemia: 200mg, 1 time, taken for 15 days (because the drug is absorbed in this group).

Fungal nail disease: 200mg, 1 time, for 3 months. Can increase the dose: 200mg/time, 2 times a day, if the disease spreads. The dose may be increased: 200mg, 2 times a day, if the disease spreads. Maintain treatment: 200mg, 1 -time daily.

Preventive in neutropenia: 200mg/time, 1 time.

No need to change the dose in patients with renal function and in the elderly.

What to do when overdose? In case of overdose, use of supportive measures such as gastric lavage or activated carbon.

What to do when you forget 1 dose?

Side Effects

Most unwanted effects are light and transient. Constipation, nausea, digestive disorders, abdominal pain, headache, allergic reactions.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Contraindications for patients with hypersensitivity to Itraconazole or any excipients of the drug.

contraindicated use with terfenadin with iTraconazole. Due to the chemical similarities of itraconazole and ketoconazole, contraindicated use with astemizole with iTraconazol.

Contraindicated to use iTraconazole and triazolam are drinking. Oral midazolam and cisaprid.

Do not use iTraconazole for pregnant and lactating women, children.

Be cautious when using

Periodic testing of liver enzyme in patients with liver function abnormalities before.

When detecting clinical signs and symptoms of liver disease may be caused by iTraconazole, Canditral should be stopped.

The effect of the drug on the ability to drive and operate machinery

should be cautious because sometimes there may be headaches.

Use drugs for women during pregnancy and lactation

Pregnant women:

There is no adequate and well -controlled Itraconazole in pregnant women. Patients should consult a physician if pregnant or likely to be pregnant during treatment.

breastfeeding women:

Because iTraconazole is excreted in breast milk, does not take medicine for nursing women.

Medicinal interaction

Concentrated use of liver enzyme induction drugs such as rifampicin, rifabutin and phenytoin reduces the level of Itraconazole in the blood, so it should not be used simultaneously these drugs.

Due to Itraconazole inhibits the cytochrom P450 liver enzyme (special type 3A4), simultaneous use of this drug with drugs is metabolized mainly by the above enzyme that can lead to increased concentration of these drugs in plasma and therefore can increase or prolong both their unwanted treatment and effect effects.

The following drug interactions have been determined:

Terfenadin, Astemizol, Cisaprid, Midazolam oral, Triazolam, Men Reductase inhibitors HMG-COA such as lovastatin: These drugs should not be used simultaneously with iTraconazol. Must use simultaneously with iTraconazole, the dose must be reduced.

Storage

Store at temperatures not more than 30 ° C, avoid moisture and light.

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