Canesten 1 Day 500mg Bayer Vaginal Treatment Treatment of Vaginitis and External Genital (1 Blister X 1 Tablet)

Dosage form Box of 1 blister x 1 tablet
Specifications Clotrimazol
Ingredient Berlimed, S.A

Ingredient

Composition information	Content
Clotrimazol	500mg

Uses

Indications

Canesten vaginal capsules used in the treatment of vaginitis and external genitalia in women due to clotrimazole sensitive organisms, such as mushrooms (usually candidia).

Pharmacokology

Treatment effects: Anti -fungal drugs, used for vaginal placement - Imidazole and triazole.

ATC code: G01 AF02

Mechanism of action

Azoles (for example, Clotrimazole) is often recommended for treatment of vaginitis, candidic vulva is characterized by pussy - vaginal symptoms such as itching, burning, many damaged, redness, swelling and aches.

Clotrimazole has anti -fungal effects by inhibiting Ergosterol synthesis. Ergosterol synthesis inhibit the structure and activity of the mushroom cytoplasm.

Clotrimazole has a spectrum anti -fungal effect in vitro and in vivo including: skin fungus, yeast, mushrooms (for example, Candida), mold and other mushrooms ...

In appropriate testing conditions, mic value of clotrimazole for these mushrooms is below 0.062 - 8.0 µg/ml of substrate.

The activity of clotrimazole is mushroom pliers or fungicides depending on the clotrimazole concentration at the fungal infection. In-Vitro test shows that the drug limits the growth of mushroom components, while mildly sensitive mushroom spores.

In addition to anti-fungal effects, Clotrimazole also works on gram microorganisms (+) (Streptococci / Staphylococci / Gardnerellavaginalis), and Gram (-) (BACTOIDES).

In-vitro, Clotrimazole inhibits the multiplication of corynebacteria and Gram (+) bacteria (excluding Enterococci) at a concentration of 0.5-10 µg/ml of substrate.

Anti -primary drugs of sensitive fungal strains rarely occur; The appearance of secondary drug resistance of sensitive fungal strains is only detected in very few single cases when treating drugs.

Dynamic pharmacokinetics

Dynamic pharmacokinetic studies show that, after placing the drug, only a small amount of clotrimazole (3 - 10%) is absorbed. Because the amount of clotrimazole absorption is metabolized through the liver quickly into metabolites that are no longer active, the peak concentration of plasma of clotrimazole after the dose of 500mg is below 10ng/ml. This result shows that the use of Clotrimazole places vagina almost less body effects or significant side effects.

Before taking Canesten 1 Day 500mg Bayer Vaginal Treatment Treatment of Vaginitis and External Genital (1 Blister X 1 Tablet)

How to use

Soft capsules of Canesten vagina should be placed in the evening before going to bed into the vagina as deep as possible with the drug applied tools provided in the product box. It is best to put the drug in the back position, the knee is slightly folded.

During pregnancy, the vagina should be placed with a finger, do not use the medication tool, to avoid damaging the cervix.

Instructions for ordering drugs:

Wash your hands before taking the medicine out of the blister and wash it after placing it.

Remove the drug device from the box. Pull the head of a piston until it stops. Remove the tablet from the blister and put the tablet firmly at the head of the drug B of the drug tool. The tablet fits the medication device. Hold the drug tool, slowly press the pit tone until it stops completely to put the drug into the vagina. To keep the drug in a safe place, out of reach of children. It is impossible to discharge the drug device through the toilet.
Dosage

Single dose 1 vaginal placement in the evening.
If symptoms do not get better after 7 days of treatment, patients need to consult a doctor.
Canesten treatment may be repeated when necessary. However, recurrent cases may have a background disease. Patients should see a doctor if symptoms recur within 2 months.
If the lips of the vulva and surrounding areas are infected with infection, it is recommended to combine the vaginal and topical treatment with an external cream.
Gynecological drugs for adults and children aged 16 and older.
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? There is no specific antidote.
However, in case of accidentally swallowing, rarely need to wash the stomach and only consider gastric lavage if the clinical symptoms due to overdose become clear (for example: dizziness, nausea or vomiting).
Should only take the stomach when there are adequate airway protection measures.
The following adverse reactions have been recorded when the clotrimazole overdose is acute: abdominal pain, upper abdominal pain, diarrhea, discomfort, nausea and vomiting.
In an emergency, call the 115 emergency center immediately or go to the nearest local health station.
What to do when forgetting 1 dose?

Side Effects

The frequency of unwanted effects in the table below obtained from the clinical studies of Clotrimazole preparation forms used by vaginal lines.

popular Agency System (from> 1/100 to 1 Unsatisfactory (from> 1/1000 to rarely (from> 1/10000 to Abdominal pain Breeding and breast disorders The vaginal vaginal burning sensation

vaginal itching, vulva

Disadvantous vulva vaginal area

Vaginal bleeding common disorders and at the position of drug placement on -site irritating

edema Prayer from an unknown sample size, so it is not estimated that the frequency appears based on the existing data (unknown frequency of appearance).

Immune system disorders: Anaphylactic reaction, angioedema, hypersensitivity

blood vessel disorders: fainting, lowering blood pressure

Respiratory disorders, chest and mediastinum: Difficulty

Digestive disorders: Abdominal pain, nausea

Skin disorders and subcutaneous tissue: Rolles, itching, itching. Vaginal skin, vaginal discharge, vaginal bleeding, vaginal vaginal rash, discomfort of vaginal vaginal vaginal area, vaginal burning sensation, vaginal vaginal itching, vaginal pain.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Soft capsules of Canesten vaginal contraindications in the following cases:

sensitive to Clotrimazole or any ingredients of the drug

Be cautious when using

should consult a doctor in case the first symptoms of fungal vaginitis.

Consult your doctor before taking the drug if there is any of the following problems:

available on two fungal vaginitis in the past 6 months. Other.

Do not use Canesten but should consult a doctor if the patient has any of the following symptoms:

abnormal menstrual periods; abnormal vaginal bleeding or blood fluids; ulcers, sores or blisters in the vulva or vagina; lower abdominal pain or urination; Any adverse event, such as redness, irritation or swelling due to treatment; Fever (≥38 ° C) or chills, nausea or vomiting; back-ache; diarrhea; vaginal discharge has a bad smell; and/or shoulder pain. The treatment should be completed before menstruation.

Do not use tampons (tampon), vaginal indent, spermicide or other vaginal products when using Canesten.

Should avoid intercourse when vaginitis and when using.

Canesten Preventing Inflammation can be transmitted to a partner.

Sexes should also be treated on the spot if symptoms, such as itching, inflammation, ...

Treatment for partners can help prevent re -infection.

contraceptive effect and reliability of contraceptive methods with Latex, such as condoms and vaginal diaphragm, may be reduced.

When using the drug during pregnancy, do not use the drug tool.

Patients should consult a doctor if the symptoms do not get better within a week after using Canesten.

Canesten can be repeated if the fungal infection returns after 7 days. However, if fungal vaginitis occurs twice for 6 months, patients should consult a doctor.

Avoid contact with eyes.

Do not swallow.

The effect of the drug on the ability to drive and operate machinery

does not have or negatively affect the ability to drive and use machinery.

Use drugs for women during pregnancy and lactation

Pregnant women:

Although the amount of clinical data on pregnant women is limited, animal studies with clotrimazole show that reproductive toxicity at high doses when taken orally. When using Clotrimazole in vaginal treatment, with low systemic exposure, it does not show direct or indirect harm to reproductive toxicity. Clotrimazole may be used during pregnancy, but under the guidance of doctors.

Canesten vagina can be used during pregnancy because it is possible to order without using drug tools.

Need to keep special genital hygiene in the last 4 - 6 months of pregnancy.

breastfeeding women:

There is no data on clotrimazole excretion into breast milk. However, the absorption of drugs into the body after use is minimum and seems to be able to cause systemic effects.

Clotrimazole can be used during breastfeeding.

reproductive ability:

No research has been conducted on people on the effects of clotrimazole on fertility, however, animal studies have not proved any effects of the drug on fertility.

Drug interaction

Laboratory tests suggest that when used simultaneously, this product may damage contraceptive methods with Latex. Therefore, the effectiveness of these contraceptives may be reduced. Patients should be consulted to use alternative preventive measures for at least five days after using this product.

Simultaneous treatment of Clotrimazole vaginal tablets with oral tacrolimus (FK-506; immunosuppressive) can lead to an increase in the concentration of Tacrolimus in plasma and similar to syrolimus. Therefore, patients should be monitored with the kidneys of the symptoms of Tacrolimus or Sirolimus overdose, if necessary, determine the concentration in the corresponding plasma.

Clotrimazole is the average inhibitor of the liver microsomer isoenzyme and is the weak inhibitor of the isoenzyme CYP2C9, 3-10% of the clotrimazole dose is absorbed into the circulatory system of the body. This may affect the concentration of metabolic drugs through isenzyme CYP3A4 in particular, capable of increasing the plasma concentration of these substances when used simultaneously. Because of the weak effect on the isoenzyme CYP2C9 and only a small amount of clotrimazole used on the spot is absorbed the whole body, Clotrimazole has little influence on the concentration of metabolic drugs through Isoenzyme CYP2C9. Therefore, because Clotrimazole is very rarely absorbed by vaginal lines, especially at a dose of 500 mg with a single dose, Clotrimazole vaginal form is very little capable of causing any clinical drug interactions.

Tyeum of drugs

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Store at a temperature not exceeding 30 ° C in the original packaging, avoid moisture and avoid light.

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