Canesten 500mg Bayer vagina supports the treatment of vaginitis (1 tablet)

Dosage form 1 tablet box
Specifications Clotrimazole
Ingredient Vaginitis, vaginal mushrooms, candidiasis, headaches

Ingredient

Composition information	Content
Clotrimazole	500mg

Uses

indications

Canesten 1 daytherapy 500 mg is indicated in cases of local vaginitis treatment due to:

Mushrooms (usually Candida).

Code ATC: D01AC01

Mechanism of action

Clotrimazol has an anti -fungal effect by inhibiting Ergosterol synthesis. Ergosterol synthesis inhibit the structure and activity of the mushroom cytoplasm.

Clotrimazol has a spectrum anti -fungal effect in both in vitro and in vivo including: skin fungus, yeast, mold, etc.

In appropriate testing conditions, the mic value of these mushrooms is less than 0.062 - 8.0 ng/ml of substrate. The mechanism of acting of clotrimazol is a fungus or fungal pliers depending on the clotrimazol level at the fungal infection position. In-Vitro activity limits the growth of mushroom components, and the mushroom spores are only very sensitive.

In addition to anti-fungal effects, Clotrimazol also works on Gram (+) microorganisms (Streptococci/ Staphylococci/ Gardnerella Vaginalis), and Gram (-) (BACTOIDES) microorganisms.

On in -vitro, clotrimazol inhibits the multiplication of corynebacteria and Gram (+) () (excluding Enterococci) at a concentration of 0.5 - 10 ng/ml of substrate.

The antigen of sensitive fungal strains rarely occurs; The development of secondary resistance of sensitive fungal strains is only detected in very few single cases when treating drugs.

pharmacokinetics

Pharmacokinetic studies after treatment show that only a small amount of clotrimazol (3 - 10%) is absorbed.

Because the amount of clotrimazol absorption is metabolized through the liver quickly into metabolic substances that are no longer active, the peak concentration of plasma of clotrimazole after the dose of 500 mg is less than 10 ng/ml, this result shows that the use of Clotrimazol places vagina almost less body effects or significant side effects.

Before taking Canesten 500mg Bayer vagina supports the treatment of vaginitis (1 tablet)

How to use

Canesten medicine, vaginal placement should be placed in the evening before going to bed into the vagina as deep as possible. See the instructions for placing the drug below:

Wash your hands before taking the medicine out of the blister and wash it after placing it.

1. Remove the drug device from the box. Pull the A Tong A head until it stops. Remove the tablet from the taste and put the pills firmly in the top of the drug b.

2. To put the tablet into the drug device, squeeze the head of the tip of the device. The tablet fits the medication and should be pushed inside about 1 cm deep.

3. Put carefully to the vaginal placement as deep as possible (it is best to put the drug in a lying position, the knee is slightly folded). Keep the drug instrument from pressing the piston until it stops completely to put the drug in the vagina.

4. Draw the drug device. To keep the drug in a safe place, out of reach of children. Do not discharge drugs through the toilet.

Canesten vagina needs moisture in the vagina to completely decay, if not only the non -soluble pieces may be pushed out of the vagina. To prevent this situation, it is important to put the drug in the vagina as deep as possible at bedtime. In case the pill does not completely decay for 1 night, should consider using the vaginal cream.

If symptoms do not get better after 7 days of treatment, patients need to consult a doctor.

Canesten treatment may be repeated when necessary, but recurrence may have a cause. Patients should see a doctor if the symptoms return within 2 months.

If the lips and surrounding areas are infected with infections, it is recommended to combine the vagina and local treatment with an external cream. The partner should also be treated on the spot if there are symptoms such as itching, inflammation, ...

Should not be treated while menstruation.

Treatment should be completed before menstruation.

Do not use tampons, vaginal indenting tools, spermicide or other vaginal products while using Canesten.

Avoid having sex when there is vaginitis and when using Canesten prevention can be transmitted to a partner.

During pregnancy should not be used for placing drugs to place the vagina canal.

Medicines for adults and children aged 12 and older.

Dosage

Single dose 1 vaginal placement in the evening.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? There is no specific antidote.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? Do not use double the prescribed dose.

Side Effects

When using Canesten 1 Daytherapy 500 mg, you may experience unwanted effects (ADR).

The following side effects are recorded during the use of clotrimazol. These reactions are voluntarily reported from an unknown size population, so it is not reliable to estimate the frequency of appearance.

Immune system disorders: allergic reactions (fainting, hypotension, shortness of breath, urticaria).

Breeding and breast disorders: Genital, redness, itching, rash, edema, discomfort, burning, irritation, pelvic pain. Vaginal bleeding.

Digestive disorders: abdominal pain.

Notice immediately to the doctor or pharmacist the harmful reactions encountered when using the drug.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Canesten 1 daytherapy 500mg contraindications in cases of clotrimazol sensitive or any ingredients of the drug.

Caution should be used

If the patient has a fever (temperature 38 ° C or higher), lower abdominal pain, back pain, vaginal discharge with odor, nausea, vaginal bleeding, and/or shoulder pain, patients should consult a doctor. Do not use clotrimazol for the treatment of systemic fungi.

If irritated or sensitive when using clotrimazol, medication and appropriate treatment must be stopped.

Report to a physician if there is a manifestation of increased irritation at the place of the drug (redness, itching, burns, blisters, swelling), signs of hypersensitivity.

Avoid sources of infection or re -infection.

Avoid contact with the eyes. Do not swallow.

The ability to drive and operate machinery

drugs do not have or negatively affect the ability to drive and use machinery.

Pregnancy

data on the use of clotrimazol in limited pregnant women. Animal studies do not show direct or indirect harm to reproductive toxicity. As a preventive measure, it is best to avoid using Clotrimazol for the first 3 months of pregnancy.

Canesten vagina can be used during pregnancy because it is possible to order without using drug tools.

Breastfeeding period

Data on pharmacokinetics and animal toxicity shows clotrimazol and metabolites secreted milk. Should stop breastfeeding during treatment with clotrimazol.

Medicinal interaction

Simultaneous use of Clotrimazol The vagina with oral tacrolimus (immunosuppressive FK-506) can lead to increased plasma tacrolimus concentration. Therefore, patients should be carefully monitored the symptoms of Tacrolimus overdose, if the concentration is needed in the corresponding plasma.

Storage

Storage below 30 ° C.

Expiry date: 24 months from the date of manufacture. Do not use overdue drugs stated on the packaging.

Manufacturer: Bayer Pharma Ag.

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