Canvey Farmaprim vaginal vagina treats vaginal infections (2 blisters x 5 tablets)

Dosage form Ltd Farmaprim
Specifications Moldova, Republic of
Ingredient Moldova

Ingredient

Composition information	Content
Metronidazole	225mg
Chloramphenicol success	100mg
Dexamethasone	0.5mg
Nystatin	75mg

Uses

Indications

Canvey 2x5 placement is indicated in the following cases: The treatment of mixed bacterial infections in the vagina, vaginitis accompanied by white blood, itching caused by bacterial and fungal infections, trichomonas vaginitis, vaginitis due to mixed causes, prevention of vaginal fungal infections.

Pharmacology

Canvey has a formula that combines many compounds, thus having the effect of local vaginitis due to various causes such as parasitic infections, bacterial infections, fungal infections, or many pathogens at the same time. The drug is coordinated:

metronidazole

is a substance with wide antibacterial activity on protozoa such as amoeba, Giardia Lambia and anaerobic bacteria. Metronidazole has the effect of killing bacteria on bacteroides, fusobacteriuml and other mandatory anaerobic bacteria but does not have the effect on noni bacteria.

Metronidazole is only resistant to a few cases. However, when using Metronidazole alone to treat Campylobacter, Helicobacter pylori, the drug resistance is growing too fast. When infected with both aerobic and anaerobic bacteria, Metronidazole must be combined with other antibacterial drugs.

Trichomonas vaginalis infection can be treated with Metronidazole or localized. Both women and men must be treated, because men can carry pathogens without symptoms. In some cases, it is necessary to treat vaginal and tablet medicine.

Metronidazole will cause the vaginal bacteria to return to normal when cervicitis or bacterial vagina. In the vast majority of patients taking drugs, Metronidazole usually does not affect the normal vaginal bacteria.

chloramphenicol

Chloramphenicol is an antibiotic, originally isolated from the Venezuelae Streptomyces, now produced by synthetic method.

Chloramphenicol often works to inhibit the growth of bacteria, but can kill bacteria at high concentrations or for bacteria with high sensitivity.

chloramphenicol antibacterial effects by mechanism: inhibition of protein synthesis in sensitive bacteria by attaching to the mini of the ribosom 50s. The drug has the same position to work with other antibiotics such as: erythromycin, clindamycin, lincomycin, oleandomycin and troleandomycin.

Chloramphenicol also has the ability to inhibit protein synthesis in rapid proliferation cells of mammals. Chloramphenicol may cause bone marrow inhibition and may not recover. Chloramphenicol has immunosuppressive activity if used for the whole body before the antigen stimulates the body. However, antibodies may not be significantly affected when using chloramphenicol after antigen.

nystatin

Nystatin is a anti -fungal antibiotic extracted from streptomyces noursei mushroom culture, yellow powder, very little soluble in water. Nystatin works to inhibit the growth of mushrooms or fungicides depending on the concentration and sensitivity of the fungus, which does not affect the normal bacteria on the body. The most sensitive nystatin is yeast and has a very good effect on Candida Albicans.

Mechanism of action: Nystatin changes the permeability of the mushroom membrane due to the binding to the sterol of the cell membrane of sensitive mushrooms. Nystatin can still be tolerated well even when long -term treatment and non -drug resistance.

dexamathason

dexamathason is Floumethylprednisolon, synthetic glucocorticoid, almost insoluble in water. The glucocorticoids act on the cell receptor, the transfusion into the cell nucleus and there has affected some code -translated genes. Glucocorticoids also have some direct effects, which may not be intermediaries connected to the receptor.

Dexamathason has the main effect of glucocorticoids: Anti -inflammatory, anti -allergy that inhibits immunity, while the effect of electrolyte balance is very few. In terms of anti -inflammatory activity, Dexamethason is more powerful than Hydrocortison, 7 times stronger than prednisolon.

Dynamic pharmacokinetics

metronidazole

Put a single dose of 5 g of the vaginal gel (equivalent to 37.5 mg of metronidazole), the medium serum metronidazole concentration is 237 nanogam/ml. This concentration is about 2% of Metronidazole concentration maximum moderate in serum after taking 500 mg of metronidazole (the average CMAX is 12,875 nanogam/ml). These peak concentrations reached 6 - 12 hours after using the gel in the vagina.

Metronidazole is usually absorbed very quickly after drinking, about 80% after only 1 hour. Metronidazol is excreted mainly in urine.

nystatin

Nystatin is not absorbed through the skin or mucosa when used on the spot, excreted mainly in feces in the form of unprocessed.

dexamethason

dexamethasone as well as well -absorbed corticosteroids at the position of medication and then are distributed into all tissues in the body. The drug through the placenta and a small amount of milk. Dexamethasone is highly absorbed in the liver, kidney and adrenal glands. Metabolism in the liver slowly and excreted mainly through urine, most in the form of non -conjugate steroids.

Half of the lifetime of plasma is 3.5 - 4.5 hours, but when it comes to effects, often use half a biological life. The half -life of the biological life of dexamethasone is 36 - 54 hours, so the drug is especially suitable for diseases that need glucocorticoid -acting glucocorticoids.

Before taking Canvey Farmaprim vaginal vagina treats vaginal infections (2 blisters x 5 tablets)

How to use

before placing, put the pill in the freezer compartment for about 5-10 minutes before use.

Clean vaginal hygiene and use a soft towel to dry (absolutely do not douche deep inside).

Lie on your back in bed in a knee position, 2 legs wide.

Use 2 fingers to clamp the tablet tightly and push deeper into the vagina as possible.

lie still in the spot for at least 20 minutes after placing the drug.

Remember to clean your hands both before and after contact with Canvey.

To achieve the best treatment results, when putting the drug, use the finger to push the pills as deep as the vagina as possible.

Dosage

Cases of infections, fungal infections, vaginitis accompanied by white blood, itching caused by bacterial and fungal, vaginitis caused by trichomonas, vaginitis due to mixed causes of mixed fungal infections.

Cases of infections, fungal infections, vaginitis due to mixed causes

Put 1 bullet daily (before going to bed). Average time of treatment: 10 - 12 days.

Trichomonas vaginitis

Put 1 tablet/time/day in the evening, maintain continuously for 10-12 days.

Prevention of vaginal infections

Put 1 capsule in the evening, maintain continuously for 7-10 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Overdose can lead to leukopenia and peripheral sensory neuropathy, recovery when stopping treatment. Nausea, vomiting, diarrhea, dyeing urine (dark due to Metronidazole overdose).

Handling

Stop medication and symptomatic treatment.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Canvey, you may experience unwanted effects (ADR).

Local reactions (> 1%) include minor burns, irritation, vaginal irritation, vaginal itching. Especially when there is an open damage. Itching especially when starting treatment, but no treatment.

Allergic reactions including rash.

If the effects are not desirable, not clear, there is no need to stop the drug.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

CANVY drugs contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug: History of hypersensitivity to metronidazol or other nitro - imidazol derivatives, hypersensitivity to nystatin, patients with hypersensitivity and/or toxic reactions caused by chloramphenicol.

hypersensitivity to dexamethason; Systemic mushrooms, local virus infections or tuberculosis, gonorrhea are not controlled by antibacterial drugs.

Be cautious when using

avoid sex during treatment. To prevent re -infection, it is necessary to treat your partner simultaneously. Canvey may reduce the effectiveness of mechanical contraception. To avoid infecting your partner or preventing unwanted pregnancy, it is best not to have sex during medication.

Must use the medication enough time, although the symptoms are relieved. After 4 weeks of treatment, if not supported again.

Avoid sources of infection or re -infection.

may reduce the reliability of mechanical contraception (condoms, vaginal diaphragm) due to the interaction of bullets and rubber membranes.

Be cautious when used for people with severe liver dysfunction.

The ability to drive and operate machinery

There has been no report that affects the ability to drive and operate machinery.

Pregnancy

The safety of the drug when used for pregnant women has not been established, so it should not be used in this period.

The period of breastfeeding

Caution should consider using it during this period. Should consider stopping breastfeeding when using the drug.

Drug interaction

Sperm kills: Do not coordinate (the risk of disabling the trichomonas killers on the spot contraceptive effect of spermicide).

Do not coordinate with alcohol, disulfurame (causing acute paranoia, mental).

Metronidazole increases the effects of anticoagulants, especially Warafin, so avoid taking the drug at the same time.

metronidazol has a disulfiram -style effect. Therefore, do not simultaneously coordinate these 2 drugs together to avoid the toxic effect on the nerves such as psychosis, confusion.

If simultaneously used phenobarbital and metronidazol, Phenobarbital will increase metronidazol metabolism, so Metronidazol is faster.

Use Metronidazol for patients who are using lithium (high blood lithium concentration) will increase the concentration of lithium lithium, toxic.

metronidazole increases the effect of vecuronium is a reducing muscle relaxant.

Do not use chloramphenicol simultaneously with antibacterial antibiotics, drugs that work on hematopoietic systems, cooumarin, hydratoin and methotrexate.

Storage

Store in a cool dry place, avoid light, store at a temperature not exceeding 30 ° C.

Keep drugs out of reach of children.

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