Capesto 40 USA PHARMA USA Treatment Treatment of gastroesophageal reflux - esophagus, gastric ulcer - duodenum (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Esomeprazol
Ingredient US Pharma USA

Ingredient

Thành phần cho 1 viên

Composition information	Content
Esomeprazol	40mg

Uses

indications

Capesto 40 drugs are indicated in the following cases:

Gastroesophageal reflux syndrome.

Pharmacokology

Capesto 40 contains Esomeprazol is the isomorphic form of omeprazol that reduces the secretion of gastric acid under the selective link mechanism and does not recover into the proton pump. The drug has a specific affinity for H+/K+ - Atpase enzyme (proton pump) in the cells of the gastric mucosa. This enzyme controls the final stage of the process of gastric acid secretion, so Capesto 40 inhibits the basic acid secretion process as well as due to any stimulation.

Pharmacokinetics

absorption

Esomeprazol is quickly absorbed after drinking, the peak concentration in plasma is achieved after 1-2 hours.

Esomeprazol's bioavailability increases according to the dose and when used to repeat, reaching about 68% when taking the dose of 20 mg and 89% when taking the dose of 40 mg. Food slows down and reduces the absorption, the area under the curve (AUC) after taking a single dose of 40 mg at meals compared to hunger decreases from 33 - 53%. So drink Esomeprazol 1 hour before meals.

Distribution

About 97% Esomeprazol binds to plasma proteins.

Metabolism

Esomeprazol is widely metabolized in the liver thanks to the cytochrome P450 ISOENZE CYP2C19 system into hydroxy and demethyl derivatives. The rest is converted through isenzyme CYP3A4 to Esomeprazol Sulfon. When repeated, initially metabolized through the liver and the clearance of the drug may be due to the inhibited ISOENZYM CYP2C19.

However, there is no accumulation phenomenon when used once a day. In some Asians (15 - 20%) because of the lack of genetic isoenzyme, genetic, slow to slow the metabolism of Esomeprazol, leading to AUC increased by 2 times compared to people with enough enzymes.

Elimination

Esomeprazol's exhaust time is about 1 - 1.5 hours, about 80% of the dosage dosage except in the form of non -active metabolites in the urine, the rest is deducted through feces. Under 1% of the mother is eliminated in the urine. In people with severe liver failure, AUC value is 2-3 times higher than that of people with normal liver function, so they must reduce the dose for these objects and should not use more than 20 mg daily.

Pharmacokinetics in people under 18 years of age have not been studied.

Before taking Capesto 40 USA PHARMA USA Treatment Treatment of gastroesophageal reflux - esophagus, gastric ulcer - duodenum (3 blisters x 10 tablets)

How to use

Take whole pills, do not chew or grind micro -seeds. Drink before meals (preferably before breakfast).

Dosage

Starting dose recommended in the treatment of gastroesophageal reflux disease - esophagus is from 20 to 40 mg per day, can last for more than 4-8 weeks for patients who do not heal after 4 - 8 weeks of treatment.

In the case of maintenance or diseases without symptoms of esophageal erosion, a daily dose of 20 mg.

Stomach ulcer - duodenal ulcer has Helicobacter pylori: In the trio of therapy combined with amoxicillin and clarithromycin, the usual dose is 20 mg Esomeprazol x 2 times/day for 7 days or Esomeprazol 40 mg x 1 time/day for 10 days.

Steroidal anti -inflammatory ulcer: The required dose is 20 mg or 40 mg x 1 time/day for 6 months.

Patients with hepatic impairment: No dose adjustment for patients with mild and medium liver failure. Esomeprazol dose for patients with severe liver failure must not exceed 20 mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? There is currently no specific antidote, in case of overdose should treat symptoms and use general support measures. Hemorrhage does not have the effect of eliminating drugs.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Capesto 40, you may experience unwanted effects (ADR).

Common, ADR> 1/100

headache, dizziness, abdominal pain, diarrhea, flatulence, constipation.

Uncommon, 1/1000

Dermatitis, itching, urticaria, dizziness, dry mouth.

Rare, ADR

Foul fever, peripheral edema, sensitive to light, hypersensitivity reactions include: urticaria, angioedema, bronchospasm, anaphylaxis.

Very rare

Loss of granulocytes, leukopenia, thrombocytopenia, hyper enzyme, hepatitis, liver failure, interstitial nephritis, muscle pain, joints.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Capesto 40 Contraindications to the case:

Hypersensitivity to any ingredients of the drug.

Be cautious when using

When there is the presence of vigilant symptoms such as: significant weight loss, recurrent vomiting, difficulty swallowing, vomiting blood, or defecation of black blood and when there is or suspected stomach ulcer, eliminate malignant stomach ulcers, because treatment with ecomeprazol can reduce symptoms and delay the diagnosis.

Be cautious when taking the drug for a long time because it can cause stomach atrophy.

Be cautious when used for children under 18 years old.

Be cautious when used for people with liver disease, pregnant and lactating women.

For people with renal failure, do not need to adjust the dose, but be cautious when used for patients with severe renal impairment.

The ability to drive and operate machinery

Some cases of dizziness, headache, dizziness when using Esomeprazol, so be careful to use the drug while driving or operating machinery.

Pregnancy

The drug does not affect the development of the fetus in humans and animals, but should only be used for pregnant women when necessary.

The period of breastfeeding

should not be used for women during breastfeeding. In case of medication, it is necessary to stop breastfeeding.

Drug interaction

Esomeprazol inhibits acid secretion, increases gastric pH, so the drug can affect the bioavailability of some pH -dependent absorption drugs such as ketoconazole, digoxin, iron salt.

Simultaneous use of ecomeprazol, clarithromycin and amoxicillin increases the concentrations of ecomeprazol and hydroxyclarithromycin in the blood.

Esomeprazol interact with dynamic pharmacokinetics with metabolic drugs by the cytochrom P450 enzyme system P450 isoenzyme CYP2C19 in the liver.

Simultaneously use 30 mg of Esomeprazol and Diazepam, reducing Diazepam's 45% of clearance.

Esomeprazol may increase the blood concentration of Saquinavir and reduce the concentration of Nelfinavir and Atazanavir through an unclear mechanism. Therefore, it is advisable to consider reducing the dose of Saquinavir when used with Esomeprazol to avoid the possible side effects of Saquinavir.

Esomeprazol reduces the activity of clopidogrel metabolic enzymes into an active form, thus reducing the activity of clopidogrel, so it is recommended to use only the combination of these two drugs when it is really necessary.

Esomeprazol increases the concentration of cilostazol and its metabolites. The dose of cilostazol should be reduced from 100 mg twice a day to 50 mg twice daily when used with Esomeprazol.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.