Caprovel medicine 300mg/12.5mg Sanofi treatment of primary hypertension (2 blisters x 14 tablets)

Dosage form Box of 2 blisters x 14 tablets
Specifications Irbesartan, hydrochlorothiazide
Ingredient High blood pressure

Ingredient

Composition information	Content
Irbesartan	300mg
Hydrochlorothiazide	12.5mg

Uses

Indications

Coaprovel drugs are indicated for patients with primary hypertension when treated individually with Irbesartan or Hydrochlorothiazide without controlling blood pressure at the target level.

Pharmacokological

coaprovel is a combination of an angiotensin-lL (Irbesartan) and a thiazide diuretic (hydrochlorothiazide). The combination of these ingredients creates the effect of treating hypertension, reducing more blood pressure than when used separately from each component.

Irbesartan is a strong, oral impact, selected antagonistic on the AT1 receptor of Angiotensin-LL. The drug prevents all the effects of Angiotensin-LL through AT1 receptor intermediaries, regardless of the origin or synthetic path of Angiotensin-II. Angiotensin-LL receptor selection (AT1) increases plasma and angiotensin-LL levels, reducing plasma aldosteron levels. Irbesartan has a direct impact without having to metabolize.

Hydrochlorothiazide is a thiazide diuretic. Thiazide works through the mechanism of electrolyte reabsorption in the renal tubules, directly increasing the excretion of sodium and chlor in approximately each other. The impact of hydrochlorothiazide reduces plasma volume, increases plasma renin activity, increases the secretion of aldosteron, increases the loss of potassium and bicarbonate, reducing plasma potassium. Through the Renin -Antotensin - Ordosteron system of Irbesartan, the simultaneous use of Irbesartan with Hydrochlorothiazide tends to offset the loss of potassium. When using hydrochlorothiazide, the diuretic effect on the beginning of 2 hours, and the impact reaches the highest level within 4 hours and extends the effect of 6-12 hours.

The combination of hydrochlorothiazide and irbesartan creates a decrease in blood pressure with the resonance effect through the amplitude of the drug's treatment dose. The effect of hypotension of Irbesartan when combined with hydrochlorothiazide is clearly seen after the first dose and the basic presence after 1-2 weeks, this effect reaches maximum after 6-8 weeks.

pharmacokinetics

Simultaneous use hydrochlorothiazide and Irbesartan do not impact the pharmacokinetics of each drug. Irbesartan and Hydrochlorothiazide are oral acting drugs and does not require a biological shift to be active.

absorption

When using oral coaprovel, absolute bioavailability is 60 - 80% for Irbesartan and 50 - 80% for hydrochlorothiazide. Food does not affect the bioavailability of coaprovel. The plasma peak concentration of the drug after taken is reached for 1.5 - 2 hours with Irbesartan and 1 - 2.5 hours with hydrochlorothiazide.

Distribution

Irbesartan's cohesion ratio with plasma proteins is about 96%, insignificant cohesion with blood cell components. Irbesartan's distribution voltage is 53 - 93 L. Hydrochlorothiazide binding 68% with plasma proteins and the apparent distribution integral is 0.83 - 1.14 l/kg.

Metabolism

Irbesartan is metabolized in the liver via complex and oxidation glucuronide. With less than 2% of the dosage excreted in urine is Irbesartan in the form of unchanged. Hydrochlorothiazide is not metabolized but quickly excreted by the kidneys. At least 61% of oral doses are eliminated in a constant form within 24 hours. Hydrochlorothiazide passes through the placenta but does not pass the brain barrier, and is excreted into breast milk.

Elimination

The half -life of Irbesartan is 11 - 15 hours. Stabilizing the drug concentration in plasma is achieved after 3 days after starting the drink once a day. It is not necessary to adjust the dose in the elderly. The average semi -cancellation time in plasma of hydrochlorothiazide varies from 5 to 15 hours.

Before taking Caprovel medicine 300mg/12.5mg Sanofi treatment of primary hypertension (2 blisters x 14 tablets)

How to use

oral drugs. The pill should be swallowed with an appropriate amount of liquid (like a glass of water). Coaprovel can be taken during or outside meals. Take medicine daily at the same time of the day.

It is important to use coaprovel continuously until the doctor decides to use another way. The maximum low voltage effect is achieved within 6 - 8 weeks after the beginning of treatment.

Dosage

The usual dose of coaprovel is 1 tablet/day.

Children under 18 years of age do not drink coaprovel.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Patients need to be closely monitored, symptomatic treatment and support. The processing depends on the time from taken and the severity of the symptoms. The proposed measures in the overdose treatment include vomiting and/or gastric lavage, and activated carbon. Regular monitoring of electrolytes and serum creatinine. If hypotension occurs, patients should be placed in a lying position, quickly rehydration and electrolytes.

What to do when you forget 1 dose? Do not take double the dose to compensate for the forgotten dose.

Side Effects

When using COAPREVel, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: Nausea, vomiting.

Uncommon, 1/1000

Digestive: diarrhea .

Not determined frequency

Neurological: headache . Kidney. Rarely cases of jaundice (jaundice and/or white iris of the eyes).

Instructions on how to handle ADR

Notice immediately to the doctor.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Coaprovel drugs contraindicated in the following cases:

allergies to Irbesartan or any ingredients contained in coaprovel. The obstruction of the urine.

Do not use coaprovel for children under 18 years old.

Be cautious when using

inform your doctor if you encounter one of the following conditions: diarrhea or vomiting; kidney problems, or kidney transplantation; heart and liver problem; diabetes; lupus erythematosus ; Increased primary aldosteron (the disease is associated with the production of many aldosteron hormones, causing sodium retention and hypertension).

In addition, it is necessary to notify your doctor if you are following a diet of low salt; There are signs such as abnormal thirst, dry mouth, fatigue, drowsiness, muscle spasms that cause pain, nausea, vomiting or abnormal tachycardia may be related to the excessive impact of hydrochlorothiazide (contained in coaprovel tablets); Having increased skin sensitivity to sunlight with symptoms of sunburn (such as flushing, itching, swelling, blistering) appear faster than usual; Coming to surgery or anesthesia.

hydrochlorothiazide contained in coaprovel can give positive results when testing against doping.

The ability to drive and operate machinery

has not conducted any research on the impact of coaprovel on driving and operating machinery. Coaprovel is not sure if it affects the ability to drive or control machines. However, during the treatment of hypertension, dizziness or fatigue can sometimes occur. If you have these symptoms, you need to consult your doctor before driving or operating machinery.

Pregnancy

Need to notify the doctor if you are pregnant or may be pregnant. Usually the doctor will advise you to stop using coaprovel first or when pregnant and recommend using other drugs instead of coaprovel.

Coaprovel is not recommended in the first months of pregnancy and is not used when pregnant for more than 3 months, because the drug can be a cause of danger to the baby if the mother takes this medication after the first 3 months of pregnancy.

Breastfeeding period

Need to tell the doctor if you are or start breastfeeding. Do not use coaprovel for breastfeeding women and the doctor will choose a different treatment direction for you, especially when your child is still born or a short -month.

Medicinal interaction

Caprovel's hypertension effect may increase when used simultaneously with other hypertension drugs.

It is recommended that lithium and coaprovel should not be coordinated. If it is necessary to coordinate, monitor kidneys lithium concentration.

Concomitance coaprovel use with potassium diuretics, potassium supplements, alternative salts containing potassium or drugs that can increase serum potassium level (such as sodium heparin) can lead to serum hyperpass. Recommended monitoring serum potassium concentrations in risky patients.

Medicines are affected by serum potassium disorders (such as glycoside digitalis, anti -arrhythmia): periodic monitoring of potassium.

Non -steroid anti -inflammatory drugs: The treatment of hypertension of coaprovel may be reduced.

Information about the interaction of hydrochlorothiazide :

Alcohol: There is a possibility of lowering blood pressure. Awards, especially hypotension.

Steroid anti -inflammatory drugs: may reduce diuretic effects, reduce sodium excretion and reduce the hypotension of Thiazide in some patients. TuboCurarine): Hydrochlorothiazide increases the muscle relaxation effect of non -reducing pattern. Calcium excretion.

Storage

Leave the medicine out of the reach and vision of children.

Do not use overdue drugs stated on the box and on the blister.

Store drugs at temperatures below 30 ° C.

Store the drug in the drug box to avoid desiccant.

Do not quit smoking into wastewater or family trash. Ask the pharmacist how to cancel the drug no longer used. These treatments help protect the environment.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.