Captopril 25mg Domesco medicine for hypertension, heart failure, myocardial infarction (10 blisters x 10 tablets)

Anti -hypertension effect: captopril reduces peripheral artery resistance, the drug does not impact on the cardiac supply. Kidney perfusion is maintained or increased. The glomerular filtration level usually does not change. If there is rapid hypoglycemia in patients with prolonged hypertension or very high blood pressure, the glomerular filtration level may decrease temporarily, shown in the increase in serum creatinine.

Hypotension effects occur for 60 - 90 minutes after taking the first dose. Time depends on the dose: After a normal dose, the effect usually maintains at least 12 hours. In the treatment of hypertension, the maximum treatment is achieved after 4 weeks of treatment.

Reducing left ventricular hypertrophy is achieved after 2-3 months using captopril. Hypotension effect does not depend on standing or five.

Hypotension (vertical hypotension) is common, but may occur, especially in people with a decrease in blood volume.

Heart failure treatment:

Captopril has a good anti -hypertension effect due to angiotensin II formation, which is an important growth stimulant of the heart muscle. For people with heart failure, captopril reduces the burden of money, reduces peripheral resistance, increases cardiac supply and thus increases the ability of the heart.

Hemodynamic and clinical effects often occur quickly and maintain during treatment. Clinical improvement is found in patients with poor hemodynamic effects. Kidney perfusion can increase up to 60%rapidly, this effect is usually achieved from 60 - 90 minutes after taking a dose of
and reaching the maximum effect after 3-8 hours, maintained for about 12 hours.

can combine captopril with digitalis and diuretics. Do not coordinate with potassium -keeping diuretics like spironolacton because it can lead to severe potassium potassium.

Treatment of myocardial infarction:

The benefits of ACE inhibitors are reducing the rate of myocardial infarction recurrence, possibly due to slowing atherosclerosis. Captopril reduces death after myocardial infarction. Early medication should be used in the acute myocardial infarction for all patients, even if there is a temporary sign of left ventricular dysfunction.

Dynamic pharmacokinetics

Oral bioavailability of captopril about 65%, the peak concentration of the drug in the blood is achieved after drinking an hour. Food does not affect the absorption of the drug.

The distribution integral is 0.7 liters/kg. Selling biological waste time in plasma is about 2 hours. The total clearance is 0.8 liters/kg/hour, the renal clearance is 50%, the average is 0.4 liters/kg/hour. 75% of the drug is eliminated in the urine.

50% in non -metabolic form and the rest are metabolites of captopril cysteine ​​and disulfid derivatives of captopril. Nephrotic function can cause drug accumulation.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Must be very cautious when combined with potassium diuretics such as spironolacton, triamteren, amilorid because captopril itself can cause slight increase in potassium. It is also necessary to be cautious when using salt containing potassium and must check the electrolyte balance regularly.

In patients with strong renin activity, severe hypotension may occur after the first capteil dose, sodium chloride intravenous injection is required. Hypotension at this time does not hinder the continued use of captopril. If the original dose is initially (6.25 mg or 12.5
mg), the severity of the severity will decrease.

If the surgery during anesthesia with the drug has the effect of lowering blood pressure, it should be noted that captopril prevents the formation of angiotensin II, causing secondary release of renin, leading to hypotension, should be adjusted by increasing circulating volume.

The risk of increasing anaphylactic reaction agent when using ACE inhibitors and the separation is highly absorbent, dialysis, LDL removal and during hypersensitivity - anti -allergy.

captopril also causes false positive reactions when testing acetone in urine.

Use drugs for pregnant and lactating women

Use captopril or other ACE inhibitors in the middle 3 months and the last 3 months of pregnancy can lead to fetal and infant damage including lower blood pressure, reduced neonatal product, dawn, renal failure recovery or non -recovery and death.

Little amniotic fluid may be due to fetal renal function. Protestant pregnancy, premature birth and arterioscleros have occurred. So never use captopril during pregnancy.

Captopril excreted in breast milk, causing many harmful effects for breastfed babies, so it is not allowed to use captopril and other ACE inhibitors for nursing mothers.

The effect of the drug on the ability to drive and operate machinery

The drug does not affect when driving and operating machinery.

Medicinal interaction

Simultaneously Furosemid with Captopril causes the effect of hypotension.

Simultaneous use of captopril with nonsteroidal anti -inflammatory substances (especially indomethacin) reduces the hypotension effect of captopril.

captopril may increase the lithium concentration and increase the toxicity of lithium.

Sympathetic enhancers reduce the effect of lowering blood pressure of captopril.

cyclosporin or potassium -keeping diuretics can cause an increase in potassium when used simultaneously with Captopril.